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Synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-ones catalyzed by biodegradable ionic liquid

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Abstract

A biodegradable acyclic SO3H-functionalized ionic liquid has been used as a novel catalyst for the synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-ones via one-pot multi-component condensation of β-naphthol, aromatic aldehydes, and cyclic 1,3-dicarbonyl compounds, under solvent-free conditions, to afford good to excellent yields ranging from 85 to 93 % within 30–60 min. After the reaction the products could be simply separated from the reaction mixture and the catalyst could be recycled and reused several times without noticeable reduction of catalytic activity.

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Acknowledgments

We express our sincere thanks to the Ministry of Science and Technology of the P.R. China (11C26213201395), Jiangsu Provincial Department of Education (JHB2011-52), and the Key Laboratory of Organic Synthesis of Jiangsu Province (KJS1112) for financial assistance.

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Authors and Affiliations

  1. Department of Pharmaceutical Engineering, Yancheng Normal University, 50 Kai Fang Da Dao Yancheng, Jiangsu, 224002, People’s Republic of China

    Dong Fang, Jin-ming Yang & Yan-fang Cao

Authors
  1. Dong Fang
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  2. Jin-ming Yang
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  3. Yan-fang Cao
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Correspondence to Dong Fang.

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Fang, D., Yang, Jm. & Cao, Yf. Synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-ones catalyzed by biodegradable ionic liquid. Res Chem Intermed 39, 1745–1751 (2013). https://doi.org/10.1007/s11164-012-0709-4

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  • DOI: https://doi.org/10.1007/s11164-012-0709-4

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