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Efficient synthesis of 2-amino-3-cyano-4H-pyran derivatives via a non-catalytic one-pot three-component reaction

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Abstract

A convenient one-pot multi-component strategy was conducted successfully under catalyst-free conditions employing water and PEG-400 as the efficient and cheap promoting medium. Three types and nearly 50 2-amino-3-cyano-4H-pyran annulated derivatives were synthesized in good to excellent yields by the condensation of a series of aromatic aldehydes with malononitrile and different 1,3-dicarbonyl compounds. Broad substrate scope, systematic characterization, eliminated catalyst, brief reaction time, and simple purification procedure are the best merits in this process.

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Acknowledgements

We are grateful for financial support from the National Natural Science Foundation of China (21403100), Natural Science Foundation of Liaoning Province (20141100), and Department of Education of Liaoning Province (L2014421).

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, 116029, People’s Republic of China

    Cheng-Wei Lü, Jia-Jing Wang, Fei Li, Shi-Jun Yu & Yue An

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  1. Cheng-Wei Lü
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Correspondence to Cheng-Wei Lü.

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Lü, CW., Wang, JJ., Li, F. et al. Efficient synthesis of 2-amino-3-cyano-4H-pyran derivatives via a non-catalytic one-pot three-component reaction. Res Chem Intermed 44, 1035–1043 (2018). https://doi.org/10.1007/s11164-017-3151-9

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