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Synthesis, spectroscopic properties, crystal structures, antioxidant activities and enzyme inhibition determination of Co(II) and Fe(II) complexes of Schiff base

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Abstract

Considering the importance of metal complexes in the development of medical science, two different Schiff base Fe(II) and Co(II) metal complex compounds were synthesized with Schiff base obtained through the condensation of 1-(4-aminophenyl)ethanone with 2-hydroxy-3-methoxybenzaldehyde. The reactions of the ligand with Co(II) and Fe(II) metal ions enabled six coordination compounds with octahedral geometries. The novel metal complexes were characterized by IR, elemental analyses, magnetic susceptibility, mass spectra, UV–Vis, thermogravimetry–differential thermal analysis (TGA–DTA) and X-ray diffraction analysis. The antioxidant properties of the new compounds were investigated using different in vitro assays. Moreover, enzyme inhibition of derivatives complexes against carbonic anhydrase I and II isoenzymes (CA I and II) and acetylcholinesterase (AChE) was evaluated. The best inhibitor complex for CA I and II isoenzymes was the Fe(II) complex with Ki values of 52.83 ± 11.52 and 63.34 ± 8.88, respectively.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Arts and Sciences, Muş Alparslan University, 49250, Muş, Turkey

    Kenan Buldurun & Nevin Turan

  2. Department of Nursing, School of Health, Muş Alparslan University, 49250, Muş, Turkey

    Ercan Bursal

  3. Department of Physics, Faculty of Arts and Sciences, Muş Alparslan University, 49250, Muş, Turkey

    Asim Mantarcı

  4. Health Services Vocational School, Igdır University, 76000, Igdır, Turkey

    Fikret Turkan

  5. Department of Biotechnology, Faculty of Science, Bartin University, 74100, Bartin, Turkey

    Parham Taslimi

  6. Department of Chemistry, Faculty of Science, Ataturk University, 25240, Erzurum, Turkey

    İlhami Gülçin

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  1. Kenan Buldurun
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Correspondence to Kenan Buldurun.

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Buldurun, K., Turan, N., Bursal, E. et al. Synthesis, spectroscopic properties, crystal structures, antioxidant activities and enzyme inhibition determination of Co(II) and Fe(II) complexes of Schiff base. Res Chem Intermed 46, 283–297 (2020). https://doi.org/10.1007/s11164-019-03949-3

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