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Cage complexes of transition metals in biochemistry and medicine

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Abstract

The review presents the following main trends and the perspectives of application of the transition metal clathrochelates in medicine and biochemistry: encapsulation of radioactive metal ion for diagnostics and therapy; imaging agents for MRI; antidotes and prolonged pharmaceuticals; pharmaceuticals for boron neutron capture therapy; antihelminthic and antiparasitic detergents; antioxidants; membrane transport of the metal ions; interaction of the cage metal complexes with nucleic acids and the potential of their self-assembling reactions in immunology and molecular biology (recognition of antibodies, antigens and DNA sites); design of HIV inhibitors for the therapy.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 555–582, April, 2007.

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Voloshin, Y.Z., Varzatskii, O.A. & Bubnov, Y.N. Cage complexes of transition metals in biochemistry and medicine. Russ Chem Bull 56, 577–605 (2007). https://doi.org/10.1007/s11172-007-0100-6

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