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Synthesis of oligosaccharide fragments of the Streptococcus pneumoniae type 14 capsular polysaccharide and their neoglycoconjugates with bovine serum albumin

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Abstract

2-Aminoethyl glycosides of tetra-, hexa- and octasaccharide fragments of the bacteria Streptococcus pneumoniae type 14 capsular polysaccharide were synthesized within a project directed to the development of pneumococcal conjugated vaccine based on synthetic carbohydrate ligands. Squarate method was used to obtain neoglycoconjugates of the synthesized oligosaccharides with bovine serum albumin.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    E. V. Sukhova, D. V. Yashunsky, Yu. E. Tsvetkov & N. E. Nifantiev

  2. V. N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Str. 8, 10 ul. Pogodinskaya, 119121, Moscow, Russian Federation

    D. V. Yashunsky

  3. I. I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences, 5a Mal Kazennyi per., 105064, Moscow, Russian Federation

    E. A. Kurbatova

Authors
  1. E. V. Sukhova
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  2. D. V. Yashunsky
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  3. Yu. E. Tsvetkov
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  4. E. A. Kurbatova
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  5. N. E. Nifantiev
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Corresponding author

Correspondence to N. E. Nifantiev.

Additional information

On the occasion of the 80th anniversary of the N. D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 0511–0521, February, 2014.

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Sukhova, E.V., Yashunsky, D.V., Tsvetkov, Y.E. et al. Synthesis of oligosaccharide fragments of the Streptococcus pneumoniae type 14 capsular polysaccharide and their neoglycoconjugates with bovine serum albumin. Russ Chem Bull 63, 511–521 (2014). https://doi.org/10.1007/s11172-014-0462-5

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  • DOI: https://doi.org/10.1007/s11172-014-0462-5

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