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Synthesis and properties of 2-hydroxyethyl derivatives of methylene-bis(1-oxy-3, 3-dialkyl-1-triazene 2-oxides)

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Abstract

Synthetic approach to 2-hydroxyethyl derivatives of methylene-bis(1-oxy-3, 3-dialkyl-1triazene 2-oxides), promising NO donors, which can release NO in living organisms was developed. Some transformations of the hydroxyethyl moiety of the synthesized compounds were studied.

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References

  1. V. G. Granik, N. B. Grigorév, Oksid azota (NO) [Nitric oxide (NO)], Vyzovskaya kniga, Moscow, 2004, 359 pp.

    Google Scholar 

  2. J. A. Hrabie, L. K. Keefer, Chem. Rev., 2002, 102, 1135.

    Article  CAS  Google Scholar 

  3. R. S. Nandurdikar, L. K. Keefer, A. E. MacIag, Z. Cao, J. E. Saavedra, Bioorg. Med. Chem., 2012, 20, 2025.

    Article  CAS  Google Scholar 

  4. J. Kaur, A. Bhardwaj, Z. Haung, E. E. Knaus, D. Narang, T.-Y. Chen, F. Plane, J. Med. Chem., 2012, 55, 7883.

    Article  CAS  Google Scholar 

  5. Pat. WO2009094242 (A1); http://wordwide.espacenet.com.

  6. V. P. Ananikov, E. A. Khokhlova, M. P. Egorov, A. M. Sakharov, S. G. Zlotin, A. V. Kucherov, L. M. Kustov, M. L. Gening, N. E. Nifantiev, Mendeleev Commun., 2015, 25, 75.

    Article  CAS  Google Scholar 

  7. G. A. Smirnov, P. B. Gordeev, S. V. Nikitin, O. A. Lukýanov, Russ. Chem. Bull. (Int. Ed.), 2014, 63, 487 [Izv. Akad. Nauk, Ser. Khim., 2014, 487].

    Article  CAS  Google Scholar 

  8. G. A. Smirnov, T. V. Ternikova, G. V. Pokhvisneva, O. A. Lukýanov, Russ. Chem. Bull. (Int. Ed.), 2015, 64, 1062 [Izv. Akad. Nauk, Ser. Khim., 2015, 1062].

    Article  Google Scholar 

  9. G. A. Smirnov, P. B. Gordeev, S. V. Nikitin, T. V. Ternikova, G. V. Pokhvisneva, O. A. Lukýanov, Russ. Chem. Bull. (Int. Ed.), 2015, 64, 1057 [Izv. Akad. Nauk, Ser. Khim., 2015, 1057].

    Article  CAS  Google Scholar 

  10. B. J. Bedell, D. Scott Bohle, Zh. Chua, A. Czerniewski, A. C. Evans, Sh. Mzengeza, Can. J. Chem., 2010, 88, 969.

    Article  CAS  Google Scholar 

  11. C. Velazquez, E. E. Knaus, Bioorg. Med. Chem., 2004, 12, 3831.

    Article  CAS  Google Scholar 

  12. A. Cordi, L. Haberkorn, T. Verbeuren, C. Courchay, S. Simonet, Fr. Demande, Pat. FR 2924713 (A1); http://wordwide.espacenet.com.

  13. J. Zhang, J. Jiang, Yu. Li, X. Wan, J. Org. Chem., 2013, 78, 11366.

    Article  CAS  Google Scholar 

  14. R. Lazny, A. Nodzewska, K. Wolosewicz, Synthesis, 2003, 2858.

    Google Scholar 

  15. R. H. Fish, R. L. Holmstead, W. Gaffield, Tetrahedron, 1976, 32, 2689.

    Article  CAS  Google Scholar 

  16. R. N. Loeppky, W. A. McKinley, L. G. Hazlitt, J. R. Outram, J. Org. Chem., 1982, 47, 4833.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    G. A. Smirnov, S. V. Nikitin, P. B. Gordeev, G. V. Pokhvisneva, T. V. Ternikova & O. A. Luk’yanov

Authors
  1. G. A. Smirnov
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  2. S. V. Nikitin
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  3. P. B. Gordeev
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  4. G. V. Pokhvisneva
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  5. T. V. Ternikova
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  6. O. A. Luk’yanov
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Corresponding author

Correspondence to S. V. Nikitin.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2706—2711, November, 2015.

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Smirnov, G.A., Nikitin, S.V., Gordeev, P.B. et al. Synthesis and properties of 2-hydroxyethyl derivatives of methylene-bis(1-oxy-3, 3-dialkyl-1-triazene 2-oxides). Russ Chem Bull 64, 2706–2711 (2015). https://doi.org/10.1007/s11172-015-1211-0

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  • DOI: https://doi.org/10.1007/s11172-015-1211-0

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