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Zinc(II) halide and copper(II) bromide complexes with caffeine: structures, physicochemical properties, and biological activity

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Abstract

This study provides a comparative characterization of the structural parameters and cytotoxicity of zinc halide and copper(II) bromide complexes with caffeine (caf) of the composition [Zn(caf)(H2O)X2] (X = Cl, Br, I) and [Cu(caf)2Br2] (1). The cytotoxicity of the complexes is dose-dependent in all cell lines. The concentrations of the complexes, at which they are more cytotoxic against cancer cells (MCF-7) than against stem cells (DPSC), were determined. The synthesized complexes exhibited synergism of cytotoxicity.

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Authors and Affiliations

  1. M. V. Lomonosov Institute of Fine Chemical Technologies, MIREA — Russian Technological University, 86 prosp. Vernadskogo, 119571, Moscow, Russian Federation

    N. S. Rukk, T. V. Ivanova & V. N. Krasnoperova

  2. N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky prosp., 119991, Moscow, Russian Federation

    L. G. Kuzmina & G. A. Buzanov

  3. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 3 Institutskaya ul., 142290, Pushchino, Moscow region, Russian Federation

    G. A. Davydova

  4. Institute of Chemical Reagents and High Purity Chemical Substances of National Research Center “Kurchatov Institute”, 3 Bogorodskii val, 107076, Moscow, Russian Federation

    S. K. Belus, E. I. Kozhukhova, V. M. Retivov & B. M. Bolotin

Authors
  1. N. S. Rukk
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  2. L. G. Kuzmina
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  3. G. A. Davydova
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  4. G. A. Buzanov
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  5. S. K. Belus
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  6. E. I. Kozhukhova
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  7. V. M. Retivov
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  8. T. V. Ivanova
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  9. V. N. Krasnoperova
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  10. B. M. Bolotin
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Corresponding author

Correspondence to N. S. Rukk.

Additional information

Based on the materials of the XXI Mendeleev Congress on General and Applied Chemistry (September 9–13, 2019, St. Petersburg, Russia).

https://www.cancer.org/research/cancer-facts-statistics/global.html.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1394–1400, July, 2020.

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Rukk, N.S., Kuzmina, L.G., Davydova, G.A. et al. Zinc(II) halide and copper(II) bromide complexes with caffeine: structures, physicochemical properties, and biological activity. Russ Chem Bull 69, 1394–1400 (2020). https://doi.org/10.1007/s11172-020-2914-4

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  • DOI: https://doi.org/10.1007/s11172-020-2914-4

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