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Taxol: Synthesis, Bioactive Conformations, and Structure-Activity Relationships in Its Analogs

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Abstract

The review describes the syntheses and probable biologically active conformations of taxol, a natural antitumor agent, and systematizes published data on the structure-activity relations in the series of taxol analogs.

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Authors and Affiliations

  1. Faculty of Chemistry, Lomonosov Moscow State University, Vorob’evy gory 1, Moscow, 119992, Russia

    O. N. Zefirova, E. V. Nurieva, N. V. Zyk & N. S. Zefirov

  2. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii pr. 47, Moscow, 117913, Russia

    A. N. Ryzhov

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  1. O. N. Zefirova
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  2. E. V. Nurieva
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  3. A. N. Ryzhov
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Dedicated to Full Member of the Russian Academy of Sciences V. I. Minkin on his 70th Anniversary

__________

Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 3, 2005, pp. 329–362.

Original Russian Text Copyright © 2005 by Zefirova, Nurieva, Ryzhov, Zyk, Zefirov.

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Zefirova, O.N., Nurieva, E.V., Ryzhov, A.N. et al. Taxol: Synthesis, Bioactive Conformations, and Structure-Activity Relationships in Its Analogs. Russ J Org Chem 41, 315–351 (2005). https://doi.org/10.1007/s11178-005-0168-0

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