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Chromium(III)-isocinchomeronato and quinolinato complexes: kinetic studies in NaOH solutions and effect on 3T3 fibroblast proliferation

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Abstract

The aquation of chromium(III)-isocinchomeronato and quinolinato complexes, mer-[Cr(icaH)3]0 and mer-[Cr(quinH)3]0 (where icaH− and quinH− are N,O-bonded isocinchomeronic and quinolinic acid anion, respectively) was studied in NaOH solutions. The process leads to successive ligand liberation in the fully deprotonated species. The kinetics of the first ligand liberation were studied spectrophotometrically in the visible region. A mechanism is proposed in which the rate of the chelate-ring opening at the Cr–N bond is much faster than the rate of the Cr–O bond breaking. The rate-determining step is described by the rate law: k obs1 = k OH(1) + k O Q 2 [OH−], where k OH(1) and k O are rate constants of the first ligand liberation from the hydroxo- and oxo-forms of the intermediate, respectively, and Q 2 is an equilibrium constant between these two protolytic forms. The first pseudo-first-order rate constants (k obs1) were calculated using SPECFIT software for an A → B → C reaction pattern. The results are compared with those determined in acidic medium. Kinetics of the second and third ligand liberation were also studied and values of successive pseudo-first-order rate constants (k obs2, k obs3) are [OH−] independent. Effect of chromium(III)-quinolinato and isocinchomeronato complexes on 3T3 fibroblast proliferation was evaluated. Cytotoxicity of these complexes is low, suggesting they may be promising candidates as novel dietary supplements.

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Acknowledgements

The authors wish to thank Authorities of N. Copernicus University for the financial support of these studies with the Grant No. Ch-305. Hasan Marai wishes to thank Libyan Government for financial support of his Ph.D. studies in Poland.

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Authors and Affiliations

  1. Department of Chemistry, Nicolaus Copernicus University, 87-100, Torun, Poland

    Ewa Kita & Hasan Marai

  2. Department of Tissue Engineering, Nicolaus Copernicus University, 850-092, Bydgoszcz, Poland

    Miłosz Jasiński & Tomasz Drewa

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  1. Ewa Kita
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  2. Hasan Marai
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  3. Miłosz Jasiński
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  4. Tomasz Drewa
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Correspondence to Ewa Kita.

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Kita, E., Marai, H., Jasiński, M. et al. Chromium(III)-isocinchomeronato and quinolinato complexes: kinetic studies in NaOH solutions and effect on 3T3 fibroblast proliferation. Transition Met Chem 33, 585–591 (2008). https://doi.org/10.1007/s11243-008-9084-9

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  • DOI: https://doi.org/10.1007/s11243-008-9084-9

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