Skip to main content
SpringerLink
Log in

Kinetic studies on H+-catalysed aquation of chromium(III)-oxalato-asparaginato and chromium(III)-oxalato-histidinato complexes

  • Published:
Transition Metal Chemistry Aims and scope Submit manuscript

Abstract

Three chromium(III) complexes with asparagine (Asn) and histidine (His) of the [Cr(ox)2(Aa)]2− type, where Aa = N,O–Asn, N,O–His or N,N′–His, were obtained and characterized in solution. The complexes with N,O–Aa undergo acid-catalysed aquation to give a free amino acid and cis-[Cr(ox)2(H2O)2]−, whereas the complex with N,N′–His undergoes parallel reaction paths: (1) isomerization to the N,O–His complex and (2) liberation of an oxalate ligand. Kinetics of the N,O–Aa complexes in HClO4 media were studied spectrophotometrically under pseudo-first-order conditions. The absorbance changes were attributed to the chelate ring opening at the Cr–N bond. The linear dependence of rate constants on [H+] was established, and a mechanism for the chelate ring cleavage was postulated. The existence of a metastable intermediate with O-monodentate Aa ligand was proved experimentally. Effect of [Cr(ox)2(Aa)]2− on 3T3 fibroblasts proliferation was studied. The tests revealed low cytotoxicity of the complexes. Complexes with Ala, His and Cys are good candidates for biochromium sources.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Scheme 2
Fig. 3
Scheme 3
Scheme 4
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Anderson RA (1998) J Am Coll Nutr 17:548

    CAS  Google Scholar 

  2. Cefalu W, Bell-Farrow A, Stegner J et al (1999) J Trace Elem Exp Med 12:71

    Article  CAS  Google Scholar 

  3. Vincent JB (2001) Polyhedron 20:1

    Article  CAS  Google Scholar 

  4. Slesinski RS, Clarke JJ, San RHC, Gudi R (2005) Mutation Res 585:86

    CAS  Google Scholar 

  5. Nielsen FH (2007) Summary: the clinical and nutritional importance of chromium—still debated after 50 years of research. In: Vincent JB (ed) The nutritional biochemistry of Chromium(III). Elsevier, Amsterdam, pp 265–276

    Chapter  Google Scholar 

  6. Vincent JB (2010) Dalton Trans 39:3787

    Article  CAS  Google Scholar 

  7. Levina A, Codd R, Dillon CT, Lay PA (2003) Chromium in biology: toxicology and nutritional aspects. In: Karlin KD (ed) Progress in inorganic chemistry, vol 51., WileyHoboken, NJ, pp 145–250

    Google Scholar 

  8. Kita E, Lisiak R (2011) Transit Met Chem 36:855

    Article  CAS  Google Scholar 

  9. Marai H, Kita E, Wojciechowska J, Wróbel P (2012) Transit Met Chem 37. doi:10.1007/s11243-012-9579-2

  10. Anderson RA, Polansky MM, Noella AB (2004) United States Patent US 6,689,383 B1, Feb.10, 2004

  11. Metzler DE (2001) Biochemistry. Academic Press, Harcourt, p 53

    Google Scholar 

  12. Sekizaki M (1979) Bull Chem Soc Jpn 52:403

    Article  CAS  Google Scholar 

  13. Stephens FS, Vagg RS, Williams PA (1977) Acta Crystallogr Sect B Struct Crystallogr Cryst Chem 33:433

    Article  Google Scholar 

  14. Ono T, Shimanouchi H, Sasada Y, Sakurai T, Yamauchi O, Nakahara A (1979) Bull Chem Soc Jpn 52:2229

    Article  CAS  Google Scholar 

  15. Ama T, Rashid MM, Saker AK, Miyakawa H, Yonemura T, Kawaguchi H, Yasui T (2001) Bull Chem Soc Jpn 74:2327

    Google Scholar 

  16. Tessier C, Rochon FD, Beauchamp AL (2002) Inorg Chem 41:6527

    Article  CAS  Google Scholar 

  17. Pennington WT, Cordes AW, Kyle D, Wilson Junior EW (1984) Acta Crystallogr Sect C Cryst Struct Commun 40:1322

    Google Scholar 

  18. Deschamps P, Kulkarni PP, Sarkar B (2004) Inorg Chem 43:3338

    Article  CAS  Google Scholar 

  19. Flook RJ, Freeman HC, Moore CJ, Scudder ML (1973) Chem Commun 19:753

  20. Carvalho JF (2004) Acta Crystallogr Sect E: Struct Rep Online 60:m1428

    Article  Google Scholar 

  21. Madafiglio K, Manning TM, Murdoch CM, Tulip WR, Cooper MK, Hambley TW, Freeman HC (1990) Acta Cryst C46:554

    CAS  Google Scholar 

  22. MacDiarmig AG, ed-in-chief (1977) Inorg synthesis, vol 17. Mc Graw-Hill Inc, New York, p 149

  23. Kita E, Marai H, Muzioł T, Lenart K (2011) Transit Met Chem 36:35

    Article  CAS  Google Scholar 

  24. Kita E, Marai H, Jasiński M, Drewa T (2008) Transit Met Chem 33:585

    Article  CAS  Google Scholar 

  25. Kita E, Marai H, Lisiak M, Jasiński M, Drewa T (2010) Transit Met Chem 35:184

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Chemistry, N. Copernicus University, 87-100, Toruń, Poland

    Hasan Marai, Ewa Kita, Emilia Kiersikowska & Sylwia Kuchta

  2. Department of Tissue Engineering, N. Copernicus University, 850-092, Bydgoszcz, Poland

    Anna Bajek & Tomasz Drewa

Authors
  1. Hasan Marai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ewa Kita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Emilia Kiersikowska
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sylwia Kuchta
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Anna Bajek
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tomasz Drewa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ewa Kita.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Marai, H., Kita, E., Kiersikowska, E. et al. Kinetic studies on H+-catalysed aquation of chromium(III)-oxalato-asparaginato and chromium(III)-oxalato-histidinato complexes. Transition Met Chem 37, 337–344 (2012). https://doi.org/10.1007/s11243-012-9594-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11243-012-9594-3

Keywords

Search

Navigation