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DNA binding and nuclease activity of a water-soluble sulfonated manganese(III) corrole

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Abstract

The interaction of a water-soluble sulfonated Mn(III) corrole Mn(tpfc)(SO3Na)2 [tpfc = 5,10,15-tris(pentafluorophenyl)corrole] with calf thymus DNA (ct-DNA) has been studied by spectroscopic methods, and the nuclease activity of this complex has also been examined by agarose gel electrophoresis. Mn(tpfc)(SO3Na)2 exhibits weak aggregation tendency in buffer solution and can bind to ct-DNA via an outside binding mode with a binding constant of 1.25 × 104 M−1. The observed increase in Stern–Volmer quenching constant with increasing temperature indicates that the competition of the manganese corrole and ethidium bromide with ct-DNA is a dynamic process. Moreover, the manganese corrole displays good chemical nuclease activity in the presence of hydrogen peroxide via oxidative cleavage of DNA.

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Acknowledgments

The project was supported by the National Natural Science Foundation of China (20971046, 21171057), Natural Science Foundation of Guangdong Province (10351064101000000). We are thankful to Prof. Zeev Gross (Technion, Israel) for his valuable suggestions about synthesis of sulfonated corrole.

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Authors and Affiliations

  1. Department of Chemistry, South China University of Technology, Guangzhou, 510640, Peoples’ Republic of China

    Jun-Teng Huang, Xiang-Li Wang, Yang Zhang, Mian HR Mahmood, Yan-Yuan Huang & Hai-Yang Liu

  2. Department of Applied Physics, South China University of Technology, Guangzhou, 510640, Peoples’ Republic of China

    Xiao Ying

  3. Department of Chemistry and Chemical Engineering/MOE Laboratory of Bioinorganic and Synthetic Chemistry, Sun-Yat Sen University, Guangzhou, 510275, Peoples’ Republic of China

    Liang-Nian Ji

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  1. Jun-Teng Huang
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  2. Xiang-Li Wang
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Correspondence to Hai-Yang Liu.

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Huang, JT., Wang, XL., Zhang, Y. et al. DNA binding and nuclease activity of a water-soluble sulfonated manganese(III) corrole. Transition Met Chem 38, 283–289 (2013). https://doi.org/10.1007/s11243-013-9689-5

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  • DOI: https://doi.org/10.1007/s11243-013-9689-5

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