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Synthesis, structures, and Helicobacter Pylori urease inhibition of hydroxamate-coordinated oxovanadium complexes with benzohydrazone ligands

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Abstract

A new acetohydroxamate-coordinated oxovanadium(V) complex, [VOL(AE)] (1), and a new benzohydroxamate-coordinated oxovanadium(V) complex, [VOL(BE)] (2), where L is the dianionic form of N′-(2-hydroxy-5-methylbenzylidene)-2-methoxybenzohydrazide, have been synthesized and characterized by physicochemical methods and single-crystal X-ray diffraction. The V atom in each complex adopts octahedral coordination. Thermal stabilities and urease inhibitory activities of the complexes were studied. The percent inhibition of complexes 1 and 2 at the concentration of 100 μmol L−1 on Helicobacter pylori urease is 81.2 and 46.7 %, respectively. Complex 1 has an IC50 value of 27.0 μmol L−1. A molecular docking study of the complexes with the H. pylori urease was performed.

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Acknowledgments

This work was financially supported by the State Key Laboratory of Coordination Chemistry, Nanjing University.

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Authors and Affiliations

  1. Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, 116029, People’s Republic of China

    Xiao-Shan Cheng, Ji-Cai Zhang, Zhong-Lu You, Xue Wang & Hai-Hua Li

  2. State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, People’s Republic of China

    Zhong-Lu You

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  1. Xiao-Shan Cheng
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  2. Ji-Cai Zhang
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Correspondence to Zhong-Lu You.

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Cheng, XS., Zhang, JC., You, ZL. et al. Synthesis, structures, and Helicobacter Pylori urease inhibition of hydroxamate-coordinated oxovanadium complexes with benzohydrazone ligands. Transition Met Chem 39, 291–297 (2014). https://doi.org/10.1007/s11243-014-9802-4

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