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Sertraline treatment is associated with an improvement in depression and health-related quality of life in chronic peritoneal dialysis patients

  • Nephrology - Original Paper
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Abstract

Objectives

There is scarce data about effects of treatment of clinical depression in peritoneal dialysis (PD) population. We aimed to determine prevalence of depression, its association with health-related quality of life (HRQoL) and effects of sertraline treatment in PD patients.

Materials and methods

We included 124 PD patients who had been on PD at least for 6 months. Short Form of Medical Outcomes Study was used to evaluate HRQoL. Depression was screened by Beck Depression Inventory (BDI). Patients with a BDI score ≥17 were deemed to have depression and were referred to a psychiatrist for evaluation via Diagnostic and Statistical Manual for Mental Disorders (DSM-IV) of diagnosis of clinical depression. About 25 patients diagnosed with clinical depression agreed to receive antidepressant treatment (Sertraline hydrochloride, 50 mg/day) for a 12-week period. After the treatment, biochemical analyses and questionnaires were repeated.

Results

Thirty-two patients (25.8%) had depression. BDI score of patients were lower compared to those without depressive symptoms (23 ± 6.7 and 9.8 ± 3.0, respectively P < 0.001). Physical component scale (PCS) and mental component scale (MCS) domains of HRQoL were significantly decreased in patients with depression than in patients without depression (P < 0.001 for PCS and MCS). In bivariate analysis the BDI score was correlated inversely with the PCS and MCS (P < 0.001). Sertraline treatment improved BDI score of patients with depression (P < 0.001). HRQoL parameters also improved. No adverse effects requiring drug cessation was seen in the study group.

Conclusions

Treatment of depression with sertraline is associated with improvement of the HRQoL and symptoms related to depression.

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References

  1. Kimmel PL, Thamer M, Richard CM et al (1998) Psychiatric illness in patients with end-stage renal disease. Am J Med 105:214–221

    Article  CAS  PubMed  Google Scholar 

  2. Juergensen PH, Zemchenkov A, Watnick S et al (2002) Comparison of quality-of-life assessment in Russia and the United States in chronic peritoneal dialysis patients. Adv Perit Dial 18:55–57

    PubMed  Google Scholar 

  3. Finkelstein FO, Finkelstein SH (2000) Depression in chronic dialysis patients: assessment and treatment. Nephrol Dial Transplant 15:1911–1913

    Article  CAS  PubMed  Google Scholar 

  4. Watnick S, Kirwin P, Mahnensmith R et al (2003) The prevalence and treatment of depression among patients starting dialysis. Am J Kidney Dis 41:105–110

    Article  PubMed  Google Scholar 

  5. Turk S, Atalay H, Altintepe L et al (2006) Treatment with antidepressive drugs improved quality of life in chronic hemodialysis patients. Clin Nephrol 65:113–118

    CAS  PubMed  Google Scholar 

  6. Mittal SK, Ahern L, Flaster E et al (2001) Selfassessed quality of life in peritoneal dialysis patients. Am J Nephrol 21:215–220

    Article  CAS  PubMed  Google Scholar 

  7. Einwohner R, Bernardini J, Fried L et al (2004) The effect of depressive symptoms on survival in peritoneal dialysis patients. Perit Dial Int 24:256–263

    PubMed  Google Scholar 

  8. Troidle L, Watnick S, Wuerth DB et al (2003) Depression and its association with peritonitis in long-term peritoneal dialysis patients. Am J Kidney Dis 42:350–354

    Article  PubMed  Google Scholar 

  9. Hedayati SS, Bosworth HB, Briley LP et al (2008) Death or hospitalization of patients on chronic hemodialysis is associated with a physician-based diagnosis of depression. Kidney Int 74:930–936

    Article  PubMed  Google Scholar 

  10. Boulware LE, Liu Y, Fink NE et al (2006) Temporal relation among depression symptoms, cardiovascular disease events, and mortality in end-stage renal disease: contribution of reverse causality. Clin J Am Soc Nephrol 1:496–504

    Article  PubMed  Google Scholar 

  11. Kutner NG, Zhang R, Huang Y et al (2008) Patient-reported sleep difficulty and cognitive function during the first year of dialysis. Int Urol Nephrol l 40:203–210

    Article  Google Scholar 

  12. Son YJ, Choi KS, Park YR et al (2009) Depression, symptoms and the quality of life in patients on hemodialysis for end-stage renal disease. Am J Nephrol 29:36–42

    Article  PubMed  Google Scholar 

  13. Paniagua R, Amato D, Vonesh E et al (2005) Mexican nephrology collaborative study group. Health-related quality of life predicts outcomes but is not affected by peritoneal clearance: the ADEMEX trial. Kidney Int 67:1093–1104

    Article  PubMed  Google Scholar 

  14. Wuerth D, Finkelstein SH, Kliger AS et al (2003) Chronic peritoneal dialysis patients diagnosed with clinical depression: results of pharmacologic therapy. Semin Dial 16:424–427

    Article  PubMed  Google Scholar 

  15. Wuerth D, Finkelstein SH, Ciarcia J et al (2001) Identification and treatment of depression in a cohort of patients maintained on chronic peritoneal dialysis. Am J Kidney Dis 37:1011–1017

    Article  CAS  PubMed  Google Scholar 

  16. Davies SJ, Phillips L, Naish PF et al (2002) Quantifying comorbidity in peritoneal dialysis patients and its relationship to other predictors of survival. Nephrol Dial Transplant 17:1085–1092

    Article  PubMed  Google Scholar 

  17. Watnick S, Wang PL, Demadura T et al (2005) Validation of 2 depression screening tools in dialysis patients. Am J Kidney Dis 46:919–924

    Article  PubMed  Google Scholar 

  18. Hedayati SS, Bosworth HB, Kuchibhatla M et al (2006) The predictive value of self-report scales compared with physician diagnosis of depression in hemodialysis patients. Kidney Int 69:1662–1668

    Article  CAS  PubMed  Google Scholar 

  19. Kimmel PL, Peterson RA, Weihs KL et al (2000) Multiple measurements of depression predict mortality in a longitudinal study of chronic hemodialysis outpatients. Kidney Int 57:2093–2098

    Article  CAS  PubMed  Google Scholar 

  20. Koo JR, Yoon JW, Kim SG et al (2003) Association of depression with malnutrition in chronic hemodialysis patients. Am J Kidney Dis 41:1037–1042

    Article  PubMed  Google Scholar 

  21. Hisli N (1998) Beck Depresyon Envanteri’nin geçerliligi üzerine bir çalisma. Psikoloji Dergisi 6:118–122

    Google Scholar 

  22. Ware JE Jr, Sherburne CD (1992) The MOS 36-Item short-form health survey (SF-36) I: conceptual frame work and item selection. Med Care 30:473–483

    Article  PubMed  Google Scholar 

  23. Ware JE Jr (1993) SF-36 health survey manual and interpretation guide. New England Medical Center, Health Institute, Boston

    Google Scholar 

  24. Ware JE Jr, Kosinski M, Bayliss MS et al (1995) Comparison of methods for scoring and statistical analysis of SF-36 health profile and summary measures: summary of results from the medical outcomes study. Med Care 33:264–279

    Article  Google Scholar 

  25. Johansen KL, Painter P, Kent-Braun JA et al (2001) Validation of questionnaires to estimate physical activity and functioning in end-stage renal disease. Kidney Int 59:1121–1127

    Article  CAS  PubMed  Google Scholar 

  26. Lew SQ, Piraino B (2005) Quality of life and psychological issues in peritoneal dialysis patients. Semin Dial 18:119–123

    Article  PubMed  Google Scholar 

  27. Mujais SK, Story K, Brouillette J et al. (2009) Health-related quality of life in CKD patients: correlates and evolution over time. Clin J Am Soc Nephrol (Epub ahead of print)

  28. Simic-Ogrizovic S, Jemcov T, Pejanovic S et al (2009) Health-related quality of life, treatment efficacy, and hemodialysis patient outcome. Ren Fail 31:201–206

    Article  PubMed  Google Scholar 

  29. Altintepe L, Levendoglu F, Okudan N et al (2006) Physical disability, psychological status, and health-related quality of life in older hemodialysis patients and age-matched controls. Hemodial Int 10:260–266

    Article  PubMed  Google Scholar 

  30. Kutner NG (2008) Promoting functioning and well-being in older CKD patients: review of recent evidence. Int Urol Nephrol 40:1151–1158

    Article  PubMed  Google Scholar 

  31. Steele TE, Baltimore D, Finkelstein SH (1996) Quality of life in peritoneal dialysis patients. J Nerv Ment Dis 184:368–374

    Article  CAS  PubMed  Google Scholar 

  32. Bakewell AB, Higgins RM, Edmunds ME (2002) Quality of life in peritoneal dialysis patients: decline over time and association with clinical outcomes. Kidney Int 61:239–248

    Article  PubMed  Google Scholar 

  33. Manns B, Johnson JA, Taub K et al (2003) Quality of life in patients treated with hemodialysis or peritoneal dialysis: what are the important determinants? Clin Nephrol 60:341–351

    CAS  PubMed  Google Scholar 

  34. Patel SS, Shah VS, Peterson RA et al (2002) Psychosocial variables, quality of life, and religious beliefs in ESRD patients treated with hemodialysis. Am J Kidney Dis 40:1013–1022

    Article  PubMed  Google Scholar 

  35. Fine A (1997) Compliance with CAPD prescription is good. Perit Dial Int 17:343–346

    CAS  PubMed  Google Scholar 

  36. Kimmel PL (2002) Depression in patients with chronic renal disease: what we know and what we need to know. J Psychosom Res 53:951–956

    Article  PubMed  Google Scholar 

  37. McRae AL, Brady KT (2001) Review of sertraline and its clinical applications in psychiatric disorders. Expert Opin Pharmacother 2:883–892

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Meram School of Medicine, Selcuk University, Hemodiyaliz Sekreterligi, Meram, Konya, Turkey

    Huseyin Atalay, Yalcin Solak, Murat Biyik, Zeynep Biyik, Mehdi Yeksan, Faruk Uguz, Halil Zeki Tonbul & Suleyman Turk

  2. Nephrology Unit, Meram Research and Training Hospital, Meram, Konya, Turkey

    Ibrahim Guney

Authors
  1. Huseyin Atalay
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  2. Yalcin Solak
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  3. Murat Biyik
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  4. Zeynep Biyik
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  5. Mehdi Yeksan
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  6. Faruk Uguz
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  7. Ibrahim Guney
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  8. Halil Zeki Tonbul
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  9. Suleyman Turk
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Correspondence to Yalcin Solak.

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Atalay, H., Solak, Y., Biyik, M. et al. Sertraline treatment is associated with an improvement in depression and health-related quality of life in chronic peritoneal dialysis patients. Int Urol Nephrol 42, 527–536 (2010). https://doi.org/10.1007/s11255-009-9686-y

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  • DOI: https://doi.org/10.1007/s11255-009-9686-y

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