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Combined training in patient with aids: improved quality of life and preserved BDNF

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Abstract

Objectives

This study aims to investigate the impact of combined exercise training on selected health status measures and quality of life in patients with AIDS

Material and methods

Thirty AIDS patients were randomly divided into two groups of combined exercise training on one hand and control on the other. Combined training consisted of aerobic and resistance exercises for a duration of 12 weeks (three sessions/week). Aerobic training consisted of walking or running on a treadmill with increasing intensity from 40 to 65% of maximal heart rate for 30–60 min. Resistance sessions were made of leg press, lateral pull down, biceps curl and chest press, with 40–65% of 1-RM, two to four sets of 12–20 repetitions. Blood samples were taken from patients around 24 h before the first and 72 h after the last training sessions and cluster of differentiation four cells (CD4), serum brain-derived neurotrophic factor (BDNF), and viral load levels as well as the quality of life were assessed

Results

The results showed that although combined exercise training did not affect CD4 and viral load, quality of life increased significantly in the training group (p = 0.04). Moreover, BDNF significantly decreased in the control group but not in the training group (p = 0.03)

Conclusions

These findings suggest that combined exercise training over 3 months resulted in increased quality of life while preventing reductions in BDNF levels in AIDS patients, while no changes in viral load and CD4 count have been noticed

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Fig. 1

adopted from Khalili et al. (27) is also included). $shows a significant difference between healthy individuals and AIDS control pre-test (p ≤ 0.05)

Fig. 2
Fig. 3

adopted from Whiteman et al. (29) is also included). *shows a significant decrease in the control group (p ≤ 0.05). $ shows a significant difference between healthy individuals and AIDS control pre-test (p ≤ 0.05)

Fig. 4

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Afzalipour Medical Faculty, Physiology Research Center and Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

    Kayvan Khoramipour

  2. Department of Exercise Physiology, Faculty of Physical Education, Islamic Azad University Islamshahr Branch, Islamshahr, Tehran, Iran

    Abbas Katanchi, Masoud Hajirasouli & Laleh Behbudi

  3. Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Kharazmi University, Tehran, Iran

    Aref Basereh

  4. Research Development Center, Taleghani Hospital, Shahid Behesti University of Medical Sciences, Tehran, Iran

    Pooneh Dehghan

  5. International Health Systems and Digital Health Expert, Lion city, Singapore

    Mehdi Khaled

  6. Athlete Health and Performance Research Centre, ASPETAR, Qatar Orthopaedic and Sports Medicine Hospital, Doha, Qatar

    Karim Chamari

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  1. Kayvan Khoramipour
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Correspondence to Kayvan Khoramipour.

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The authors declare that they have no conflict of interest.

Ethical approval and Informed consent

The manuscript was performed in accordance with the ethical standards of the Helsinki Declaration and that the participants signed an informed consent for. In addition, This study was approved by the Research and Ethics Committee in the Institute of Physical Education and Sport Sciences guidelines (IR.SSRC.REC.1398.014).

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Khoramipour, K., Katanchi, A., Hajirasouli, M. et al. Combined training in patient with aids: improved quality of life and preserved BDNF. Sport Sci Health 18, 39–46 (2022). https://doi.org/10.1007/s11332-021-00771-6

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  • DOI: https://doi.org/10.1007/s11332-021-00771-6

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