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Bioaccumulation of ytterbium oxide nanoparticles insinuate oxidative stress, inflammatory, and pathological lesions in ICR mice

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Abstract

With the rapid development in nanoscience and nanotechnology, rare earth oxide nanomaterials (REO-NMs) have been increasingly used due to their unique physical and chemical characteristics. Despite the increasing applications of REO NPs, scarce information is available on their detrimental effects. In the current study, we investigate the toxic effect of ytterbium oxide nanoparticles (Yb2O3 NPs) in mouse model by using various techniques including inductively coupled plasma mass spectrometry (ICP-MS) analysis over 30 days of exposure. Furthermore, we elucidated lung lavage fluid of mice for biochemical and cytological analysis, and lung tissues for histopathology to interpret the NP side effects. We observed a significant concentration of Yb2O3 NPs accumulated in the lung, liver, kidney, and heart tissues. Similarly, increased bioaccumulation of Yb content was found in the olfactory bulb compared to other reigns of brain. The cytological analysis of bronchoalveolar lavage fluid (BALF) revealed a significant elevation in the percentage of neutrophils and lymphocytes. Biochemical analysis showed an instilled Yb2O3 NPs, showing signs of oxidative damage through up-regulation of 60–87% of MDA while down-regulation of 20–40% of GSH-PX and GSH content. The toxicity pattern was more evident from histopathological observations. These interpretations provide enough evidence of bioaccumulation of Yb2O3 NPs in mice tissues. Overall, our findings reveal that acute exposure of Yb2O3 NPs through intranasal inhalation may cause toxicity via oxidative stress, which leads to a chronic inflammatory response.

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Funding

The project was financially supported by the National Key R&D Program of China (Grant Nos. 2017YFD0801300 and 2017YFD0801103), the NSFC-Guangdong Joint Fund (Grant No. U1401234), the National Natural Science Foundation of China (Grant Nos. 41371471 and 31501791), and the Key National Natural Science Foundation of China (Grant No. 41130526).

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Authors and Affiliations

  1. Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China

    Muhammad Adeel, Jin Tingting, Muhammad Kashif Irshad, Noman Shakoor, Yi Hao & Yukui Rui

  2. Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China

    Tariq Hussain

  3. Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, People’s Republic of China

    Xiao He, Xie Changjian & Zhang Zhiyong

  4. Key Lab of Eco-restoration of Regional Contaminated Environment, Ministry of Education, Shenyang University, Shenyang, 110044, People’s Republic of China

    Muhammad Arslan Ahmad

  5. Department of Tissue Engineering, China Medical University, Shenyang, 110122, People’s Republic of China

    Muhammad Arslan Ahmad & Rabia Javed

  6. School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham, UK

    Peng Zhang

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  1. Muhammad Adeel
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  2. Jin Tingting
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  4. Xiao He
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  8. Peng Zhang
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  13. Yukui Rui
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Contributions

Muhammad Adeel, Jin Tingting, and Muhammad kashif Irshad designed and performed experiment. Xie Changjian, Muhammad Arslan Ahmad, Yi Hao, Muhammad Adeel, and Tariq Hussain drafted the article. Xiao He, Yukui Rui, Rabia Javed, and Zhang Zhiyong critically evaluated and approved final version of draft.

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Correspondence to Yukui Rui.

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Adeel, M., Tingting, J., Hussain, T. et al. Bioaccumulation of ytterbium oxide nanoparticles insinuate oxidative stress, inflammatory, and pathological lesions in ICR mice. Environ Sci Pollut Res 27, 32944–32953 (2020). https://doi.org/10.1007/s11356-020-09565-8

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