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A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malaysian Mitragyna speciosa and its opioid agonistic activity

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Abstract

A new indole alkaloid, 7-hydroxyspeciociliatine (1), was isolated from the fruits of Malaysian Mitragyna speciosa Korth., together with 11 known indole and oxindole alkaloids (3–13). The structure of the new compound was determined by spectroscopic analysis and chemical conversion. The opioid agonistic activity of the new alkaloid was investigated in guinea-pig ileum experiments. The compound was found to have a weak stimulatory effect on μ-opioid receptors.

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Acknowledgements

This work was financially supported in part by Grants-in Aid for Scientific Research from the Ministry of Education, Culture, Sports, Sciences and Technology, Japan, and by Uehara Memorial Foundation.

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan

    Mariko Kitajima, Kaori Misawa, Noriyuki Kogure, Yoshio Hatori, Toshihiko Murayama & Hiromitsu Takayama

  2. Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia

    Ikram M. Said

  3. Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba, 283-8555, Japan

    Syunji Horie

Authors
  1. Mariko Kitajima
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  2. Kaori Misawa
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  3. Noriyuki Kogure
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  4. Ikram M. Said
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  5. Syunji Horie
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  6. Yoshio Hatori
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  7. Toshihiko Murayama
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  8. Hiromitsu Takayama
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Correspondence to Hiromitsu Takayama.

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Kitajima, M., Misawa, K., Kogure, N. et al. A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malaysian Mitragyna speciosa and its opioid agonistic activity. J Nat Med 60, 28–35 (2006). https://doi.org/10.1007/s11418-005-0001-7

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  • DOI: https://doi.org/10.1007/s11418-005-0001-7

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