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Bioactive cyclobutane-containing alkaloids

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Abstract

The present review describes research on novel natural cyclobutane-containing alkaloids and synthetic compounds isolated from terrestrial and marine species. More than 210 compounds have been confirmed to show antimicrobial, antibacterial, anticancer, and other activities. Structures, origins, biosynthesis, photodimerization, and biological activities of a selection of cyclobutane-containing alkaloids and selected synthethic analogs of natural alkaloids are reviewed.

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  1. Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University of Jerusalem, P.O. Box 12065, Jerusalem, 91120, Israel

    Valery M. Dembitsky

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Dembitsky, V.M. Bioactive cyclobutane-containing alkaloids. J Nat Med 62, 1–33 (2008). https://doi.org/10.1007/s11418-007-0166-3

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