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Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells

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Abstract

Chaga mushrooms, the sclerotium of Inonotus obliquus, have been used in Mongolia as a traditional hair shampoo to maintain healthy hair. Bioassay-guided fractionations of the extract of Chaga mushrooms using a proliferation assay on human follicle dermal papilla cells (HFDPCs) gave five lanostane-type triterpenes (1–5), whose structures were identified by spectroscopic evidence. Among these, lanosterol (1), inotodiol (3), lanost-8,24-diene-3β,21-diol (4), and trametenolic acid (5) demonstrated proproliferative effects on HFDPCs more potent than minoxidil, an anti-alopecia agent, used as the positive control. The lanostane-type triterpenes (1, 3, 4, and 5) appeared to be potential candidates of new agents possibly used for hair-care with a stimulative effect on hair growth.

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Acknowledgements

This study was partly supported by JSPS KAKENHI Grant numbers JP22406024 and JP26305003, and by SVENSON Co., Ltd., Tokyo, Japan.

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan

    Kazumi Sagayama, Naonobu Tanaka & Yoshiki Kashiwada

  2. Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, 770-8513, Japan

    Naonobu Tanaka

  3. SVENSON Co., Ltd., Tokyo, 107-0052, Japan

    Takatoshi Fukumoto

Authors
  1. Kazumi Sagayama
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  2. Naonobu Tanaka
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  3. Takatoshi Fukumoto
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  4. Yoshiki Kashiwada
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Correspondence to Yoshiki Kashiwada.

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Sagayama, K., Tanaka, N., Fukumoto, T. et al. Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells. J Nat Med 73, 597–601 (2019). https://doi.org/10.1007/s11418-019-01280-0

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  • DOI: https://doi.org/10.1007/s11418-019-01280-0

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