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Leucophyllinines A and B, bisindole alkaloids from Leuconotis eugeniifolia

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Abstract

Two new bisindole alkaloids, leucophyllinines A (1) and B (2) consisting of eburnane and quebrachamine-type skeletons were isolated from the bark of Leuconotis eugeniifolia, and their structures were elucidated on the basis of spectroscopic data. Leucophyllinines A and B showed antiplasmodial activities against Plasmodium falciparum 3D7.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan

    Yiming Tang, Alfarius Eko Nugroho, Yusuke Hirasawa & Hiroshi Morita

  2. Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Takahiro Tougan & Toshihiro Horii

  3. Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia

    A. Hamid A. Hadi

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  1. Yiming Tang
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  2. Alfarius Eko Nugroho
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  3. Yusuke Hirasawa
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  4. Takahiro Tougan
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  5. Toshihiro Horii
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  6. A. Hamid A. Hadi
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  7. Hiroshi Morita
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Correspondence to Hiroshi Morita.

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Tang, Y., Nugroho, A.E., Hirasawa, Y. et al. Leucophyllinines A and B, bisindole alkaloids from Leuconotis eugeniifolia. J Nat Med 73, 533–540 (2019). https://doi.org/10.1007/s11418-019-01297-5

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  • DOI: https://doi.org/10.1007/s11418-019-01297-5

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