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Three new alkaloids from the roots of Sophora tonkinensis

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Abstract

A new β-carboline alkaloid (1) and two new matrine-type alkaloids (2 and 3), together with two known alkaloids (4 and 5), were isolated from the roots of Sophora tonkinensis. The new structures were elucidated via extensive analyses of the spectroscopic data (IR, UV, HRESIMS, NMR) and X-ray crystallography. The absolute configuration of 1 was established by electronic circular dichroism data. Herein, is the first report of β-carboline alkaloid in the plant of genus Sophora. In addition, the cytotoxic activities against HepG2 cells of compounds 1–5 were evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Among them, compounds 1, 4 and 5 showed a weak cytotoxic activity with IC50 values of 87.4 ± 7.1, 91.8 ± 3.5 and 48.9 ± 5.2 μM, respectively.

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Acknowledgements

This work was supported by the Fujian Junior Teachers Education Scientific Research Project Plan (no. JA15812), the Program for Excellent Young Talents in University of Fujian Province, the Natural Science Foundations of China (nos. 81803376, 81673319 and 81673670), Science and Technology Planning Project of Guangdong Province (nos. 2016A030303011 and 2016B030301004), Science and Technology Planning Project of Guangzhou City (201707010399), Natural Science Foundation of Guangdong Province (no. 2017A030313732) and China Postdoctoral Science Foundation (no. 2017 M620405).

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Authors and Affiliations

  1. Xiamen Key Laboratory of Traditional Chinese Medicine Bio-Engineering, Xiamen Medical College, Xiamen, 361023, China

    Chun Wu

  2. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, China

    Lijun He, Juan Qin, Yaolan Li, Yubo Zhang & Guocai Wang

  3. Key Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian Province University, Xiamen, 361023, China

    Chun Wu & Xue Yi

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  1. Chun Wu
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  2. Lijun He
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  4. Juan Qin
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  5. Yaolan Li
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  6. Yubo Zhang
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Wu, C., He, L., Yi, X. et al. Three new alkaloids from the roots of Sophora tonkinensis. J Nat Med 73, 667–671 (2019). https://doi.org/10.1007/s11418-019-01313-8

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