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SPME–GC–MS analysis of α-pyrrolidinovaleorophenone in blood in a fatal poisoning case

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Abstract

We provided toxicological analytical support for a fatal case of abuse of α-pyrrolidinovaleorophenone (α-PVP). Solid-phase microextraction (SPME) and capillary gas chromatography coupled to mass spectrometry (GC–MS) was employed to quantify the drug in whole blood. The whole blood concentration of the drug in the heart was 486 ng/ml. This is the first report of α-PVP intoxication as ascertained by mass spectrometric identification of α-PVP in whole blood.

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Authors and Affiliations

  1. Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, Isehara, Kanagawa, 259-1143, Japan

    Takeshi Saito, Hiromichi Aoki & Sadaki Inokuchi

  2. Department of Forensic Medicine, Institute of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima, 734-8551, Japan

    Akira Namera

  3. Department of Forensic Medicine, Tokai University School of Medicine, Isehara, Kanagawa, 259-1143, Japan

    Motoki Osawa

Authors
  1. Takeshi Saito
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  2. Akira Namera
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  3. Motoki Osawa
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  4. Hiromichi Aoki
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  5. Sadaki Inokuchi
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Correspondence to Takeshi Saito.

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Saito, T., Namera, A., Osawa, M. et al. SPME–GC–MS analysis of α-pyrrolidinovaleorophenone in blood in a fatal poisoning case. Forensic Toxicol 31, 328–332 (2013). https://doi.org/10.1007/s11419-013-0183-8

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  • DOI: https://doi.org/10.1007/s11419-013-0183-8

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