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PdCl2-catalyzed heterocyclotrimerization in MeOH/scCO2: A versatile approach to dimethyl pyridine-3,5-dicarboxylate from methyl acrylate and urea

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Abstract

A novel and green method for the synthesis of dimethyl pyridine-3,5-dicarboxylate has been developed. It is PdCl2-catalyzed heterocyclotrimerization of methyl acrylate with urea in methanol/supercritical carbon dioxide. The target compound was obtained with a 75% isolated yield under the optimized conditions.

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Authors and Affiliations

  1. College of Chemistry, South China University of Technology, Guangzhou, 510640, China

    Bo Zou & HuanFeng Jiang

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  1. Bo Zou
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  2. HuanFeng Jiang
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Correspondence to HuanFeng Jiang.

Additional information

Supported by the National Natural Science Foundation of China (Grant Nos. 20332030, 20572027, 20625205 and 20772034) and Guangdong Natural Science Foundation (Grant No. 07118070)

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Zou, B., Jiang, H. PdCl2-catalyzed heterocyclotrimerization in MeOH/scCO2: A versatile approach to dimethyl pyridine-3,5-dicarboxylate from methyl acrylate and urea. Sci. China Ser. B-Chem. 51, 447–451 (2008). https://doi.org/10.1007/s11426-008-0055-y

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  • DOI: https://doi.org/10.1007/s11426-008-0055-y

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