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Simultaneous kinetic spectrophotometric determination of norfloxacin and rifampicin in pharmaceutical formulation and human urine samples by use of chemometrics approaches

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Abstract

A kinetic spectrophotometric method with aid of chemometrics is proposed for the simultaneous determination of norfloxacin and rifampicin in mixtures. The proposed method was applied for the simultaneous determination of these two compounds in pharmaceutical formulation and human urine samples, and the results obtained are similar to those obtained by high performance liquid chromatography.

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Authors and Affiliations

  1. The State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, China

    YongNian Ni

  2. Department of Chemistry, Nanchang University, Nanchang, 330031, China

    Yong Wang & YongNian Ni

  3. School of Physical and Chemical Sciences, Queensland University of Technology, Brisbane, 4001, Australia

    Serge Kokot

Authors
  1. Yong Wang
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  2. YongNian Ni
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  3. Serge Kokot
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Corresponding author

Correspondence to YongNian Ni.

Additional information

Supported by the National Natural Science Foundation of China (Grant No. 20562009), Opening Fund from the State Key Lab of Chemo/Biosensing and Chemometrics (Hunan University) (Grant No. 2005-22), Jiangxi Province Natural Science Foundation (Grant No. 0620041) and Program for Changjiang Scholars and Innovative Research Team in Universities (Grant No. IRT0540)

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Wang, Y., Ni, Y. & Kokot, S. Simultaneous kinetic spectrophotometric determination of norfloxacin and rifampicin in pharmaceutical formulation and human urine samples by use of chemometrics approaches. Sci. China Ser. B-Chem. 51, 776–785 (2008). https://doi.org/10.1007/s11426-008-0083-7

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  • DOI: https://doi.org/10.1007/s11426-008-0083-7

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