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Manganese-catalyzed bicyclic annulations of imines and α,β-unsaturated esters via C−H activation

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Abstract

A manganese-catalyzed bicyclic annulation of imines with α,β-unsaturated esters via C–H activation is described, which provides an expedient access to fused β-lactams in one-step operation with high efficiency and good functional group tolerance. Of note, both ketimines and aldimines are amenable to this transformation. Mechanistic studies have identified a five-membered azamanganacycle as the key reaction intermediate.

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Authors and Affiliations

  1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China

    Yuanyuan Hu & Congyang Wang

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Yuanyuan Hu & Congyang Wang

Authors
  1. Yuanyuan Hu
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  2. Congyang Wang
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Correspondence to Congyang Wang.

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Hu, Y., Wang, C. Manganese-catalyzed bicyclic annulations of imines and α,β-unsaturated esters via C−H activation. Sci. China Chem. 59, 1301–1305 (2016). https://doi.org/10.1007/s11426-016-0164-8

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  • DOI: https://doi.org/10.1007/s11426-016-0164-8

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