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Stem Cell Transplantation: A Promising Therapy for Parkinson’s Disease

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Abstract

Parkinson’s disease is one of the most common neurodegenerative diseases caused by the loss of dopaminergic neurons in the substantia nigra pars compacta. Pharmacological therapies are valuable but suffer from two main drawbacks: side effects and loss of efficacy with disease progression. Surgical treatment is no better than drugs. Transplantation of embryonic mesencephalic tissue has emerged as a therapeutic alternative, but the unstable efficiency and the shortage of embryonic donors limit its clinical application. Recent advances in stem cell research inspire our hope that stem cell transplantation to replace degenerated neurons may be a promising therapy for Parkinson’s disease. There are three sources of stem cells currently in testing: embryonic stem cells, neural stem cells, and mesenchymal stem cells. The stem cell transplantation in the animal model of Parkinson’s disease proves that it is capable of relieving symptoms and restoring damaged brain function. Future stem cell research should focus not only on ameliorating the symptoms of Parkinson’s disease but also on neuroprotection or neurorescue that can favorably modify the natural course and slow the progression of the disease.

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References

  • Adkins HB, Bianco C, Schiffer SG, Rayhorn P, Zafari M, Cheung AE, Orozco O, Olson D, De Luca A, Chen LL, Miatkowski K, Benjamin C, Normanno N, Williams KP, Jarpe M, LePage D, Salomon D, Sanicola M (2003) Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo. J Clin Invest 112:575–587

    Article  PubMed  CAS  Google Scholar 

  • Akerud P, Canals JM, Snyder EY, Arenas E (2001) Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson’s disease. J Neurosci 21:8108–8118

    PubMed  CAS  Google Scholar 

  • Anonymouns (2001) Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson’s disease N Engl J Med 345:956–963

    Article  Google Scholar 

  • Armstrong RJ, Hurelbrink CB, Tyers P, Ratcliffe EL, Richards A, Dunnett SB, Rosser AE, Barker RA (2002) The potential for circuit reconstruction by expanded neural precursor cells explored through porcine xenografts in a rat model of Parkinson’s disease. Exp Neurol 175:98–111

    Article  PubMed  Google Scholar 

  • Baier PC, Schindehutte J, Thinyane K, Flugge G, Fuchs E, Mansouri A, Paulus W, Gruss P, Trenkwalder C (2004) Behavioral changes in unilaterally 6-hydroxy-dopamine lesioned rats after transplantation of differentiated mouse embryonic stem cells without morphological integration. Stem Cells 22:396–404

    Article  PubMed  CAS  Google Scholar 

  • Baldassarre G, Tucci M, Lembo G, Pacifico FM, Dono R, Lago CT, Barra A, Bianco C, Viglietto G, Salomon D, Persico MG (2001) A truncated form of teratocarcinoma-derived growth factor-1 (cripto-1) mRNA expressed in human colon carcinoma cell lines and tumors. Tumour Biol 22:286–293

    Article  PubMed  CAS  Google Scholar 

  • Barberi T, Klivenyi P, Calingasan NY, Lee H, Kawamata H, Loonam K, Perrier AL, Bruses J, Rubio ME, Topf N, Tabar V, Harrison NL, Beal MF, Moore MA, Studer L (2003) Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in Parkinsonian mice. Nat Biotechnol 21:1200–1207

    Article  PubMed  CAS  Google Scholar 

  • Barker RA, Widner H (2004) Immune problems in central nervous system cell therapy. NeuroRx 1:472–481

    Article  PubMed  Google Scholar 

  • Bjorklund LM, Sanchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O (2002) Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A 99:2344–2349

    Article  PubMed  CAS  Google Scholar 

  • Black SP, Constantinidis I, Cui H, Tucker-Burden C, Weber CJ, Safley SA (2006) Immune responses to an encapsulated allogeneic islet beta-cell line in diabetic NOD mice. Biochem Biophys Res Commun 340:236–243

    PubMed  CAS  Google Scholar 

  • Blanco-Bose WE, Schneider BL, Aebischer P (2006) Inducing tolerance to a soluble foreign antigen by encapsulated cell transplants. Mol Ther 13:447–456

    Article  PubMed  CAS  Google Scholar 

  • Brederlau A, Correia AS, Anisimov SV, Elmi M, Paul G, Roybon L, Morizane A, Bergquist F, Riebe I, Nannmark U, Carta M, Hanse E, Takahashi J, Sasai Y, Funa K, Brundin P, Eriksson PS, Li JY (2006) Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson’s disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells (Dayton, Ohio) 24:1433–1440

    Article  CAS  Google Scholar 

  • Campos LS, Leone DP, Relvas JB, Brakebusch C, Fassler R, Suter U, ffrench-Constant C (2004) Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance. Development 131:3433–3444

    Article  PubMed  CAS  Google Scholar 

  • Chapuis S, Ouchchane L, Metz O, Gerbaud L, Durif F (2005) Impact of the motor complications of Parkinson’s disease on the quality of life. Mov Disord 20:224–230

    Article  PubMed  Google Scholar 

  • Chen Y, He ZX, Liu A, Wang K, Mao WW, Chu JX, Lu Y, Fang ZF, Shi YT, Yang QZ, Chen da Y, Wang MK, Li JS, Huang SL, Kong XY, Shi YZ, Wang ZQ, Xia JH, Long ZG, Xue ZG, Ding WX, Sheng HZ (2003) Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes. Cell Res 13:251–263

    Article  PubMed  Google Scholar 

  • D’Antonio A, Losito S, Pignata S, Grassi M, Perrone F, De Luca A, Tambaro R, Bianco C, Gullick WJ, Johnson GR, Iaffaioli VR, Salomon DS, Normanno N (2002) Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas. Int J Oncol 21:941–948

    PubMed  CAS  Google Scholar 

  • Dean SK, Yulyana Y, Williams G, Sidhu KS, Tuch BE (2006) Differentiation of encapsulated embryonic stem cells after transplantation. Transplantation 82:1175–1184

    Article  PubMed  Google Scholar 

  • Fallahi-Sichani M, Soleimani M, Najafi SM, Kiani J, Arefian E, Atashi A (2007) In vitro differentiation of cord blood unrestricted somatic stem cells expressing dopamine-associated genes into neuron-like cells. Cell Biol Int 31:299–303

    Article  PubMed  CAS  Google Scholar 

  • Ferrari G, Cusella-De Angelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, Mavilio F (1998) Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279:1528–1530

    Article  PubMed  CAS  Google Scholar 

  • Gill SS, Patel NK, Hotton GR, O’Sullivan K, McCarter R, Bunnage M, Brooks DJ, Svendsen CN, Heywood P (2003) Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med 9:589–595

    Article  PubMed  CAS  Google Scholar 

  • Hagell P, Schrag A, Piccini P, Jahanshahi M, Brown R, Rehncrona S, Widner H, Brundin P, Rothwell JC, Odin P, Wenning GK, Morrish P, Gustavii B, Bjorklund A, Brooks DJ, Marsden CD, Quinn NP, Lindvall O (1999) Sequential bilateral transplantation in Parkinson’s disease: effects of the second graft. Brain 122(Pt 6):1121–1132

    Article  PubMed  Google Scholar 

  • Harrower TP, Tyers P, Hooks Y, Barker RA (2006) Long-term survival and integration of porcine expanded neural precursor cell grafts in a rat model of Parkinson’s disease. Exp Neurol 197:56–69

    Article  PubMed  CAS  Google Scholar 

  • Hellmann MA, Panet H, Barhum Y, Melamed E, Offen D (2006) Increased survival and migration of engrafted mesenchymal bone marrow stem cells in 6-hydroxydopamine-lesioned rodents. Neurosci Lett 395:124–128

    Article  PubMed  CAS  Google Scholar 

  • Iacovitti L, Donaldson AE, Marshall CE, Suon S, Yang M (2007) A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: studies in vitro and in vivo. Brain Res 1127(1):19-25

    Article  PubMed  CAS  Google Scholar 

  • Isacson O (2004) Problems and solutions for circuits and synapses in Parkinson’s disease. Neuron 43:165–168

    Article  PubMed  CAS  Google Scholar 

  • Jang YK, Park JJ, Lee MC, Yoon BH, Yang YS, Yang SE, Kim SU (2004) Retinoic acid-mediated induction of neurons and glial cells from human umbilical cord-derived hematopoietic stem cells. J Neurosci Res 75:573–584

    Article  PubMed  CAS  Google Scholar 

  • Kim DW (2004) Efficient induction of dopaminergic neurons from embryonic stem cells for application to Parkinson’s disease. Yonsei Med J 45(Suppl):S23–S27

    Google Scholar 

  • Kim JH, Auerbach JM, Rodriguez-Gomez JA, Velasco I, Gavin D, Lumelsky N, Lee SH, Nguyen J, Sanchez-Pernaute R, Bankiewicz K, McKay R (2002) Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson’s disease. Nature 418:50–56

    Article  PubMed  CAS  Google Scholar 

  • Kim DW, Chung S, Hwang M, Ferree A, Tsai HC, Park JJ, Chung S, Nam TS, Kang UJ, Isacson O, Kim KS (2006a) Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells. Stem Cells 24:557–567

    Article  PubMed  CAS  Google Scholar 

  • Kim SU, Park IH, Kim TH, Kim KS, Choi HB, Hong SH, Bang JH, Lee MA, Joo IS, Lee CS, Kim YS (2006b) Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease. Neuropathology 26:129–140

    Article  PubMed  Google Scholar 

  • Kitajima H, Yoshimura S, Kokuzawa J, Kato M, Iwama T, Motohashi T, Kunisada T, Sakai N (2005) Culture method for the induction of neurospheres from mouse embryonic stem cells by coculture with PA6 stromal cells. J Neurosci Res 80:467–474

    Article  PubMed  CAS  Google Scholar 

  • Krack P, Batir A, Van Blercom N, Chabardes S, Fraix V, Ardouin C, Koudsie A, Limousin PD, Benazzouz A, LeBas JF, Benabid AL, Pollak P (2003) Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N Engl J Med 349:1925–1934

    Article  PubMed  CAS  Google Scholar 

  • Li Y, Chen J, Wang L, Zhang L, Lu M, Chopp M (2001) Intracerebral transplantation of bone marrow stromal cells in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. Neurosci Lett 316:67–70

    Article  PubMed  CAS  Google Scholar 

  • Liste I, Garcia-Garcia E, Martinez-Serrano A (2004) The generation of dopaminergic neurons by human neural stem cells is enhanced by Bcl-XL, both in vitro and in vivo. J Neurosci 24:10786–10795

    Article  PubMed  CAS  Google Scholar 

  • Liu WG, Lu GQ, Li B, Chen SD (2007) Dopaminergic neuroprotection by neurturin-expressing c17.2 neural stem cells in a rat model of Parkinson’s disease. Parkinsonism Relat Disord 13:77–88

    Article  PubMed  Google Scholar 

  • Love S, Plaha P, Patel NK, Hotton GR, Brooks DJ, Gill SS (2005) Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain. Nat Med 11:703–704

    Article  PubMed  CAS  Google Scholar 

  • Lu L, Zhao C, Liu Y, Sun X, Duan C, Ji M, Zhao H, Xu Q, Yang H (2005) Therapeutic benefit of TH-engineered mesenchymal stem cells for Parkinson’s disease. Brain Res Brain Res Protoc 15:46–51

    Article  PubMed  CAS  Google Scholar 

  • Maitra A, Arking DE, Shivapurkar N, Ikeda M, Stastny V, Kassauei K, Sui G, Cutler DJ, Liu Y, Brimble SN, Noaksson K, Hyllner J, Schulz TC, Zeng X, Freed WJ, Crook J, Abraham S, Colman A, Sartipy P, Matsui S, Carpenter M, Gazdar AF, Rao M, Chakravarti A (2005) Genomic alterations in cultured human embryonic stem cells. Nat Genet 37:1099–1103

    Article  PubMed  CAS  Google Scholar 

  • Martinat C, Bacci JJ, Leete T, Kim J, Vanti WB, Newman AH, Cha JH, Gether U, Wang H, Abeliovich A (2006) Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proc Natl Acad Sci USA 103:2874–2879

    Article  PubMed  CAS  Google Scholar 

  • McGuckin CP, Forraz N, Allouard Q, Pettengell R (2004) Umbilical cord blood stem cells can expand hematopoietic and neuroglial progenitors in vitro. Exp Cell Res 295:350–359

    Article  PubMed  CAS  Google Scholar 

  • McLaughlin D, Tsirimonaki E, Vallianatos G, Sakellaridis N, Chatzistamatiou T, Stavropoulos-Gioka C, Tsezou A, Messinis I, Mangoura D (2006) Stable expression of a neuronal dopaminergic progenitor phenotype in cell lines derived from human amniotic fluid cells. J Neurosci Res 83:1190–1200

    Article  PubMed  CAS  Google Scholar 

  • Mehler MF, Mabie PC, Zhu G, Gokhan S, Kessler JA (2000) Developmental changes in progenitor cell responsiveness to bone morphogenetic proteins differentially modulate progressive CNS lineage fate. Dev Neurosci 22:74–85

    Article  PubMed  CAS  Google Scholar 

  • Mueller D, Shamblott MJ, Fox HE, Gearhart JD, Martin LJ (2005) Transplanted human embryonic germ cell-derived neural stem cells replace neurons and oligodendrocytes in the forebrain of neonatal mice with excitotoxic brain damage. J Neurosci Res 82:592–608

    Article  PubMed  CAS  Google Scholar 

  • Nunes I, Tovmasian LT, Silva RM, Burke RE, Goff SP (2003) Pitx3 is required for development of substantia nigra dopaminergic neurons. Proc Natl Acad Sci USA 100:4245–4250

    Article  PubMed  CAS  Google Scholar 

  • Nutt JG, Burchiel KJ, Comella CL, Jankovic J, Lang AE, Laws ER, Jr., Lozano AM, Penn RD, Simpson RK, Jr., Stacy M, Wooten GF (2003) Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology 60:69–73

    PubMed  CAS  Google Scholar 

  • Ohmachi S, Watanabe Y, Mikami T, Kusu N, Ibi T, Akaike A, Itoh N (2000) FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain. Biochem Biophys Res Commun 277:355–360

    Article  PubMed  CAS  Google Scholar 

  • Okabe S, Forsberg-Nilsson K, Spiro AC, Segal M, McKay RD (1996) Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech Dev 59:89–102

    Article  PubMed  CAS  Google Scholar 

  • Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, Nadal-Ginard B, Bodine DM, Leri A, Anversa P (2001) Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA 98:10344–10349

    Article  PubMed  CAS  Google Scholar 

  • Ostenfeld T, Tai YT, Martin P, Deglon N, Aebischer P, Svendsen CN (2002) Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons. J Neurosci Res 69:955–965

    Article  PubMed  CAS  Google Scholar 

  • Palmer TD, Schwartz PH, Taupin P, Kaspar B, Stein SA, Gage FH (2001) Cell culture. Progenitor cells from human brain after death. Nature 411:42–43

    Article  PubMed  CAS  Google Scholar 

  • Pan Y, Chen X, Wang S, Yang S, Bai X, Chi X, Li K, Liu B, Li L (2005) In vitro neuronal differentiation of cultured human embryonic germ cells. Biochem Biophys Res Commun 327:548–556

    Article  PubMed  CAS  Google Scholar 

  • Parish CL, Parisi S, Persico MG, Arenas E, Minchiotti G (2005) Cripto as a target for improving embryonic stem cell-based therapy in Parkinson’s disease. Stem Cells 23:471–476

    Article  PubMed  CAS  Google Scholar 

  • Park S, Kim EY, Ghil GS, Joo WS, Wang KC, Kim YS, Lee YJ, Lim J (2003) Genetically modified human embryonic stem cells relieve symptomatic motor behavior in a rat model of Parkinson’s disease. Neurosci Lett 353:91–94

    Article  PubMed  CAS  Google Scholar 

  • Roth G, Dicke U (2005) Evolution of the brain and intelligence. Trends Cogn Sci 9:250–257

    Article  PubMed  Google Scholar 

  • Roy NS, Cleren C, Singh SK, Yang L, Beal MF, Goldman SA (2006) Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med 12:1259–1268

    Article  PubMed  CAS  Google Scholar 

  • Sanchez-Pernaute R, Studer L, Ferrari D, Perrier A, Lee H, Vinuela A, Isacson O (2005) Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation. Stem Cells 23:914–922

    Article  PubMed  Google Scholar 

  • Schuldiner M, Itskovitz-Eldor J, Benvenisty N (2003) Selective ablation of human embryonic stem cells expressing a “suicide” gene. Stem cells (Dayton, Ohio) 21:257–265

    Article  CAS  Google Scholar 

  • Smith AG, Heath JK, Donaldson DD, Wong GG, Moreau J, Stahl M, Rogers D (1988) Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 336:688–690

    Article  PubMed  CAS  Google Scholar 

  • Sonntag KC, Pruszak J, Yoshizaki T, van Arensbergen J, Sanchez-Pernaute R, Isacson O (2007) Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem cells (Dayton, Ohio) 25:411–418

    Article  CAS  Google Scholar 

  • Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y, Fukuda H, Okamoto Y, Koyanagi M, Ideguchi M, Hayashi H, Imazato T, Kawasaki H, Suemori H, Omachi S, Iida H, Itoh N, Nakatsuji N, Sasai Y, Hashimoto N (2005) Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest 115:102–109

    Article  PubMed  CAS  Google Scholar 

  • Theise ND, Henegariu O, Grove J, Jagirdar J, Kao PN, Crawford JM, Badve S, Saxena R, Krause DS (2002) Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow. Exp Hematol 30:1333–1338

    Article  PubMed  Google Scholar 

  • Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L, Henegariu O, Krause DS (2000) Liver from bone marrow in humans. Hepatology 32:11–16

    Article  PubMed  CAS  Google Scholar 

  • Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM (1998) Embryonic stem cell lines derived from human blastocysts. Science 282:1145–1147

    Article  PubMed  CAS  Google Scholar 

  • Timmer M, Grosskreutz J, Schlesinger F, Krampfl K, Wesemann M, Just L, Bufler J, Grothe C (2006) Dopaminergic properties and function after grafting of attached neural precursor cultures. Neurobiol Dis 21:587–606

    Article  PubMed  CAS  Google Scholar 

  • Tsai MS, Hwang SM, Tsai YL, Cheng FC, Lee JL, Chang YJ (2006) Clonal amniotic fluid-derived stem cells express characteristics of both mesenchymal and neural stem cells. Biol Reprod 74:545–551

    Article  PubMed  CAS  Google Scholar 

  • Weiss ML, Medicetty S, Bledsoe AR, Rachakatla RS, Choi M, Merchav S, Luo Y, Rao MS, Velagaleti G, Troyer D (2006) Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson’s disease. Stem Cells 24:781–792

    Article  PubMed  CAS  Google Scholar 

  • Williams RL, Hilton DJ, Pease S, Willson TA, Stewart CL, Gearing DP, Wagner EF, Metcalf D, Nicola NA, Gough NM (1988) Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336:684–687

    Article  PubMed  CAS  Google Scholar 

  • Woodbury D, Schwarz EJ, Prockop DJ, Black IB (2000) Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61:364–370

    Article  PubMed  CAS  Google Scholar 

  • Yasuhara T, Matsukawa N, Hara K, Yu G, Xu L, Maki M, Kim SU, Borlongan CV (2006) Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson’s disease. J Neurosci 26:12497–12511

    Article  PubMed  CAS  Google Scholar 

  • Yue F, Cui L, Johkura K, Ogiwara N, Sasaki K (2006) Induction of midbrain dopaminergic neurons from primate embryonic stem cells by coculture with sertoli cells. Stem Cells 24:1695–1706

    Article  PubMed  Google Scholar 

  • Zetterstrom RH, Solomin L, Jansson L, Hoffer BJ, Olson L, Perlmann T (1997) Dopamine neuron agenesis in Nurr1-deficient mice. Science 276:248–250

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Neurology, Ruijin Hospital, Jiao Tong University School of Medicine, 197# Ruijin Er Road, Shanghai, 200025, China

    Sheng Chen & Wei-dong Le

  2. Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Science and Shanghai Jiao Tong University School of Medicine, 225# South Chongqing Road, Shanghai, 200025, China

    Yi Wang & Dehua Yang

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  1. Yi Wang
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  2. Sheng Chen
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Correspondence to Wei-dong Le.

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Wang, Y., Chen, S., Yang, D. et al. Stem Cell Transplantation: A Promising Therapy for Parkinson’s Disease. Jrnl Neuroimmune Pharm 2, 243–250 (2007). https://doi.org/10.1007/s11481-007-9074-2

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