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Selective induction hyperthermia following transcatheter arterial embolization with a mixture of nano-sized magnetic particles (ferucarbotran) and embolic materials: feasibility study in rabbits

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Abstract

Purpose

To evaluate the possibility of selective hyperthermia following transcatheter arterial embolization (TAE) with ferucarbotran using a newly developed inductive heating (IH) device.

Materials and methods

Twelve Japanese white rabbits were separated into four groups: those treated with TAE using a mixture of ferucarbotran and lipiodol (F-L group); those treated with ferucarbotran and gelatin sponge powder; those treated with saline and lipiodol; and a control group. These four groups received IH. Nine rabbits with renal VX2 carcinoma were separated into three groups: IH after TAE (IH-TAE tumor), TAE without IH (TAE tumor), and no treatment (control tumor). The temperature of the tumor was kept at 45°C for 20 min. The therapeutic effect was pathologically evaluated by TUNEL staining.

Results

In the heating rates of the kidney, the F-L group showed significantly greater values than the group in which iron was not used. In the IH-TAE tumor group, tumors could be selectively heated. In TUNEL staining, the IH-TAE tumor and TAE tumor groups showed significantly greater values of apoptosis rate than in the control tumor group.

Conclusion

IH following TAE with a mixture of ferucarbotran and lipiodol was capable of inducing selective hyperthermia with our device. However, further investigation is needed to confirm its safety and effectiveness in the treatment of malignant neoplasms in humans.

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Authors and Affiliations

  1. Department of Radiology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, 920-8641, Japan

    Shigeyuki Takamatsu, Osamu Matsui, Toshifumi Gabata, Satoshi Kobayashi, Miho Okuda & Takahiro Ougi

  2. Department of Natural Science and Technology, Kanazawa Graduate School of Engineering, Kanazawa, Japan

    Yoshio Ikehata & Isamu Nagano

  3. Cooperative Research, Center for Kanazawa University, Kanazawa, Japan

    Hideo Nagae

Authors
  1. Shigeyuki Takamatsu
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  2. Osamu Matsui
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  3. Toshifumi Gabata
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  4. Satoshi Kobayashi
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  5. Miho Okuda
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  6. Takahiro Ougi
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  7. Yoshio Ikehata
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  8. Isamu Nagano
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  9. Hideo Nagae
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Corresponding author

Correspondence to Shigeyuki Takamatsu.

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Takamatsu, S., Matsui, O., Gabata, T. et al. Selective induction hyperthermia following transcatheter arterial embolization with a mixture of nano-sized magnetic particles (ferucarbotran) and embolic materials: feasibility study in rabbits. Radiat Med 26, 179–187 (2008). https://doi.org/10.1007/s11604-007-0212-9

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  • DOI: https://doi.org/10.1007/s11604-007-0212-9

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