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Intraprocedural plaque protrusion resulting in cerebral embolism during carotid angioplasty with stenting

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Abstract

An 82-year-old man with an asymptomatic left high-grade carotid stenosis was treated with carotid artery stenting (CAS) under distal protection. The procedure consisted with predilation with a 5 × 40 mm percutaneous transluminal angioplasty (PTA) balloon, deployment of a 10 × 20 mm self-expandable stent, post-dilation with a 7 × 20 mm PTA balloon, and aspiration of debris with 60 ml of blood. The cervical carotid angiogram immediately after deflation of the distal blocking balloon demonstrated a small in-stent filling defect of the contrast medium that protruded from the anterior wall of the carotid artery. The following cranial carotid angiogram showed abrupt occlusion of the left middle cerebral artery (MCA). Because the in-stent lesion had vanished in the repeat study after recognition of this embolic event, it was suggested that an embolus had been liberated from the in-stent lesion, reaching the left MCA and obliterating it. In this case, the embolus was speculated to originate in the ruptured plaque, which protruded into the stent through the cells of the device and became liberated into the bloodstream. Attention should be paid so as not to overlook any plaque protrusion, which may be seen subsequently as a cerebral embolism on the angiogram obtained immediately after CAS.

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References

  1. Kastrup A, Groschel K, Krapf H, Brehm BR, Dichgans J, Schulz JB. Early outcome of carotid angioplasty and stenting with and without cerebral protection devices: a systematic review of the literature. Stroke 2003;34:813–819.

    Article  PubMed  Google Scholar 

  2. Cremonesi A, Manetti R, Setacci F, Setacci C, Castriota F. Protected carotid stenting: clinical advantages and complications of embolic protection devices in 442 consecutive patients. Stroke 2003;34:1936–1941.

    Article  PubMed  Google Scholar 

  3. Baim DS, Carrozza JP Jr. Stent thrombosis: closing in on the best preventive treatment. Circulation 1997;95:1098–1100.

    PubMed  CAS  Google Scholar 

  4. Andersen K, Hurlen M, Arnesen H, Seljeflot I. Aspirin non-responsiveness as measured by PFA-100 in patients with coronary artery disease. Thromb Res 2002;108:37–42.

    Article  PubMed  Google Scholar 

  5. Honda Y, Fitzgerald PJ. Stent thrombosis: an issue revisited in a changing world. Circulation 2003;108:2–5.

    Article  PubMed  Google Scholar 

  6. Kereiakes DJ, Choo JK, Young JJ, Broderick TM. Thrombosis and drug-eluting stents: a critical appraisal. Rev Cardiovasc Med 2004;5:9–15.

    Article  PubMed  Google Scholar 

  7. Ruef J, Kranzhofer R. Coronary stent thrombosis related to aspirin resistance: what are the underlying mechanisms? J Interv Cardiol 2006;19:507–509.

    Article  PubMed  Google Scholar 

  8. Wehman JC, Holmes DR Jr, Ecker RD, Sauvageau E, Fahrbach J, Hanel RA, et al. Intravascular ultrasound identification of intraluminal embolic plaque material during carotid angioplasty with stenting. Catheter Cardiovasc Interv 2006;68:853–857.

    Article  PubMed  Google Scholar 

  9. Oliver TB, Lammie GA, Wright AR, Wardlaw J, Patel SG, Peek R, et al. Atherosclerotic plaque at the carotid bifurcation: CT angiographic appearance with histopathologic correlation. AJNR Am J Neuroradiol 1999;20:897–901.

    PubMed  CAS  Google Scholar 

  10. Walker LJ, Ismail A, McMeekin W, Lambert D, Mendelow AD, Birchall D. Computed tomography angiography for the evaluation of carotid atherosclerotic plaque: correlation with histopathology of endarterectomy specimens. Stroke 2002;33:977–981.

    Article  PubMed  Google Scholar 

  11. Sadato A, Satow T, Ishii A, Ohta T, Hashimoto N. Use of a large angioplasty balloon for predilation is a risk factor for embolic complications in protected carotid stenting. Neurol Med Chir (Tokyo) 2004;44:337–342.

    Article  Google Scholar 

  12. Sprouse LR 2nd, Peeters P, Bosiers M. The capture of visible debris by distal cerebral protection filters during carotid artery stenting: is it predictable? J Vasc Surg 2005;41:950–955.

    Article  PubMed  Google Scholar 

  13. Bosiers M, de Donate G, Deloose K, Verbist J, Peeters P, Castriota F, et al. Does free cell area influence the outcome in carotid artery stenting? Eur J Vasc Endovasc Surg 2007;33:135–141.

    Article  PubMed  CAS  Google Scholar 

  14. Maleux G, Demaerel P, Verbeken E, Daenens K, Heye S, Van Sonhoven F, et al. Cerebral ischemia after filter-protected carotid artery stenting is common and cannot be predicted by the presence of substantial amount of debris captured by the filter device. AJNR Am J Neuroradiol 2006;27:1830–1833.

    PubMed  CAS  Google Scholar 

  15. Iyer V, de Donato G, Deloose K, Peeters P, Castriota F, Cremonesi A, et al. The type of embolic protection does not influence the outcome in carotid artery stenting. J Vasc Surg 2007;46:251–256.

    Article  PubMed  Google Scholar 

  16. Tsumoto T, Terada T, Tsuura M, Matsumoto H, Masuo O, Yamaga H, et al. Carotid artery stenting for stenosis with intraluminal thrombus. Neuroradiology 2006;48:54–59.

    Article  PubMed  Google Scholar 

  17. Milosevic ZV, Kocijancic IJ, Bunc M, Bajrovic FF, Zvan B. Dual cerebral protection technique during carotid stenting. J Endovasc Ther 2007;14:86–90.

    Article  PubMed  Google Scholar 

  18. Hellings WE, Ackerstaff RG, Pasterkamp G, De Vries JP, Moll FL. The carotid atherosclerotic plaque and microembolisation during carotid stenting. J Cardiovasc Surg (Torino) 2006;47:115–126.

    CAS  Google Scholar 

  19. Ho DS, Wang Y, Chui M, Wang Y, Ho SL, Cheung RT. Intracarotid abciximab injection to abort impending ischemic stroke during carotid angioplasty. Cerebrovasc Dis 2001;11:300–304.

    Article  PubMed  CAS  Google Scholar 

  20. Kittusamy PK, Koenigsberg RA, McCormick DJ. Abciximab for the treatment of acute distal embolization associated with internal carotid artery angioplasty. Catheter Cardiovasc Interv 2001;54:221–233.

    Article  PubMed  CAS  Google Scholar 

  21. Green DW, Sanchez LA, Parodi JC, Geraghty PJ, Ferreira LM, Sicard GA. Acute thromboembolic events during carotid artery angioplasty and stenting: etiology and a technique of neurorescue. J Endovasc Ther 2005;12:360–365.

    Article  PubMed  Google Scholar 

  22. Orlandi G, Fanucchi S, Gallerini S, Sonnoli C, Cosottini M, Puglioli M, et al. Impaired clearance of microemboli and cerebrovascular symptoms during carotid stenting procedures. Arch Neurol 2005;62:1208–1211.

    Article  PubMed  Google Scholar 

  23. Archie JP Jr, Feldtman RW. Linear response of collateral cerebral perfusion pressure during carotid clamping. J Surg Res 1989;46:253–255.

    Article  PubMed  Google Scholar 

  24. Bogoslovsky T, Happola O, Salonen O, Lindsberg PJ. Induced hypertension for the treatment of acute MCA occlusion beyond the thrombolysis window: case report. BMC Neurol 2006;6:46.

    Article  PubMed  Google Scholar 

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Correspondence to Kiyoshi Kazekawa.

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Aikawa, H., Kodama, T., Nii, K. et al. Intraprocedural plaque protrusion resulting in cerebral embolism during carotid angioplasty with stenting. Radiat Med 26, 318–323 (2008). https://doi.org/10.1007/s11604-008-0231-1

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  • DOI: https://doi.org/10.1007/s11604-008-0231-1

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