Abstract
We report two cases of inflammatory myofibroblastic tumor (IMT) of the lung in a 4-year-old boy and a 7-year-old girl. We performed dynamic contrastenhancement computed tomography in both of our cases and dynamic contrast enhancement magnetic resonance imaging (MRI) in one case. These dynamic studies showed a demarcated mass with delayed enhancement in both cases. A T1-weighted MR image shows a mass with homogeneous low signal intensity, and a T2- weighted image shows a mass with slightly high signal intensity. A post-contrast-enhanced T1-weighted image demonstrates homogeneous enhancement. We speculate that the delayed enhancement could be attributed to the abundant fibrous tissue, which was the main structural material of the tumor. This same finding has been described in previous reports of IMT in other organs.
Similar content being viewed by others
References
Abbott GF. Uncommon malignant tumors of the lung. In: Levy AD, Koeller KK, Chung EM, editors. Radiologic pathology. 4th edition. Vol 1. Washington, DC: Armed Forces Institute of Pathology; 2005. p. 207–208.
Kim TS, Han J, Kim GY, Lee KS, Kim H, Kim J. Pulmonary inflammatory pseudotumor (inflammatory myofibroblastic tumor): CT features with pathologic correlation. J Comput Assist Tomogr 2005;29:633–639.
Agrons GA, Rosatdo-de-Christenson ML, Kirejczyk WM, Conran RM, Stocker JT. Pulmonary inflammatory pseudotumor: radiologic features. Radiology 1998;206:511–518.
Pettinato G, Manivel JC, De Rosa N, Dehner LP. Inflammatory myofibroblastic tumor (plasma cell granuloma), clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations. Am J Clin Pathol 1990;94:538–546.
Cheuk W, Chan JKC. Timely topic: anaplastic lymphoma kinase (ALK) spreads its influence. Pathology 2001;33:7–12.
Hancock BJ, Lorenzo MD, Youssef S, Yazbeck S, Marcotte JE, Collin PP. Childhood primary pulmonary neoplasms. J Pediatr Surg 1993;28:1133–1136.
Kakitsubata Y, Theodorou SJ, Theodorou DJ, Nabeshima K, Kakitsubata S, Friedman PJ. Myofibroblastic inflammatory tumor of the lung: CT findings with pathologic correlation. Comput Med Imaging Graph 2007;31:607–613.
Diederich S, Theegarten D, Stamatis G, Luthen R. Solitary pulmonary nodule with growth and contrast enhancement at CT: inflammatory pseudotumour as an unusual benign cause. Br J Radiol 2006;79:76–78.
Irie H, Honda H, Kaneko K, Kuroiwa T, Fukuya T, Yoshimitsu K, et al. Inflammatory pseudotumor of the spleen: CT and MRI findings. J Comput Assist Tomogr 1996;20:244–248.
Yamaguchi J, Sakamoto Y, Yano T, Shimada K, Kosuge T. Spontaneous regression of inflammatory pseudotumor of the liver: report of three cases. Surg Today 2007;37:525–529.
Moon W-J, Na DG, Ryoo JW, Kim MJ, Kim YD, Lim DH, et al. Orbital lymphoma and subacute or chronic inflammatory pseudotumor: differentiation with two-phase helical computed tomography. J Comput Assist Tomogr 2003;27:510–516.
Nakamura Y, Urashima M, Nishihara R, Matsunaga A, Bekku K, Iguchi H, et al. Inflammatory pseudotumor of the kidney with renal artery penetration. Radiat Med 2007;25:541–547.
Akatsu T, Wakabayashi J, Tanimoto A, Kameyama K, Kitajima M. Inflammatory pseudotumor of the liver masquerading as hepatocellular carcinoma after a hepatitis B virus infection: report of a case. Surg Today 2006;36:1028–1031.
Kelekis NL, Warshauer DM, Semelka RC, Eisenberg LB, Woosley JT. Inflammatory pseudotumor of the liver: appearance on contrast enhanced helical CT and dynamic MR images. J Magn Reson Imaging 1995;5:551–553.
Schaefer JF, Vollmar J, Schick F, Vonthein R, Seemann MD, Aebert H, et al. Solitary pulmonary nodules: dynamic contrast- enhanced MR imaging-perfusion differences in malignant and benign lesions. Radiology 2004;232:544–553.
Kono R, Fujimoto K, Terasaki H, Muller NL, Kato S, Sadohara J, et al. Dynamic MRI of solitary pulmonary nodules: comparison of enhancement patterns of malignant and benign small peripheral lung lesions. AJR Am J Roentgenol 2007;188:26–36.
Ohno Y, Hatabu H, Takenaka D, Adachi S, Kono M, Sugimura K. Solitary pulmonary nodules: potential role of dynamic MR imaging in management: initial experience. Radiology 2002;224:503–511.
Yamashita K, Matsunobe S, Tsuda T, Nemoto T, Matsumoto K, Miki H, et al. Solitary pulmonary nodule: preliminary study of evaluation with incremental dynamic CT. Radiology 1995;194:399–405.
Marcilly MC, Howarth NR, Berthez Y. Bronchial carcinoid tumor: demonstration by dynamic inversion recovery turboflash MR imaging. Eur Radiol 1998;8:1400–1402.
Douek PC, Simoni L, Revel D, Cordier JF, Amiel M. Diagnosis of bronchial carcinoid tumor by ultrafast contrastenhancement MR imaging. AJR Am J Roentgenol 1994;163:563–564.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Takayama, Y., Yabuuchi, H., Matsuo, Y. et al. Computed tomographic and magnetic resonance features of inflammatory myofibroblastic tumor of the lung in children. Radiat Med 26, 613–617 (2008). https://doi.org/10.1007/s11604-008-0284-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11604-008-0284-1