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Efficacy and safety of Qiaoshao Formula (翘芍方) on patients with lifelong premature ejaculation of Gan (Liver) depression and Shen (Kidney) deficiency syndrome: A randomized controlled trial

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Abstract

Objective

To observe the effificacy and safety of Qiaoshao Formula (翘芍方, QSF) on patients with lifelong premature ejaculation (LPE) of Gan (Liver) depression and Shen (Kidney) defificiency syndrome.

Methods

A total of 60 LPE patients were randomly divided into treatment (QSF) and control (dapoxetine) groups. The treatment group received QSF twice a day and the control group received dapoxetine 1 to 2 h prior to planned sexual intercourse for 4 weeks. The outcomes included intra-vaginal ejaculation latency time (IELT), premature ejaculation diagnostic tool (PEDT), clinical global impression of change (CGIC), scores of Chinese medicine symptoms (CMSS), sex life satisfaction (SLS) and adverse events (AEs).

Results

In the treated group, the median IELT was 3 min vs. 1.5 min before and after treatment (P<0.05). PEDT in the treated group was reduced to 11.76±1.68 from 15.83±2.30 after treatment (P<0.05). Besides, patient's SLS was improved from 1.30±0.05 to 6.30±0.04 (P<0.05), and spouse's SLS was increased from 1.30±0.to 6.10±0.06 (P<0.05); CMSS was decrease from 14.86±3.02 to 9.62±2.87 (P<0.05). In addition, no significant AE was observed in both groups.

Conclusion

QSF may be effective and safe on LPE patients with Gan depression and Shen defificiency syndrome.

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References

  1. Gao J, Zhang X, Su P, Liu J, Xia L, Yang J, et al. Prevalence and factors associated with the complaint of premature ejaculation and the four premature ejaculation syndromes: a large observational study in China. J Sex Med 2013;10:1874–1881.

    Article  PubMed  Google Scholar 

  2. Rowland DL, Patrick DL, Rothman M, Gagnon DD. The psychological burden of premature ejaculation. J Urol 2007;177:1065–1070.

    Article  PubMed  Google Scholar 

  3. Guo J, Zhang CY, Lu BD, eds. Diagnosis and treatment of premature ejaculation. Beijing: People's Military Medical Press; 2011:47–50,134-137.

    Google Scholar 

  4. Althof SE, McMahon CG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, et al. An update of the International Society of Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE). Sex Med 2014;2:60–90.

    Article  PubMed  PubMed Central  Google Scholar 

  5. The Ministry of Health of the People's Republic of China, ed. Chinese medicine new medicine clinical research guiding principles. Beijing: China Medical Science Technology Press; 2002:276–281.

    Google Scholar 

  6. Rhoden EL, Telöken C, Sogari PR, Vargas Souto CA. The use of the simplified International Index of Erectile Function (IIEF-5) as a diagnostic tool to study the prevalence of erectile dysfunction. Int J Impot Res 2002;4:245–250.

    Article  Google Scholar 

  7. Jannini E, Maggi M, Lenzi A. Evaluation of premature ejaculation. J Sex Med 2011;8:328–334.

    Article  PubMed  Google Scholar 

  8. Symonds T, Perelman M, Althof S, Giuliano F, Martin M, May K, et al. Development and validation of a premature ejaculation diagnostic tool. Eur Urol 2007;52:565–573.

    Article  PubMed  Google Scholar 

  9. Gurkan L, Oommen M, Hellstrom WJG. Premature ejaculation: current and future treatments. Asian J Androl 2008;10:102–105.

    Article  CAS  PubMed  Google Scholar 

  10. Zhao JY, Wang F, Yu GJ, Gao QH, Guo J. Clinical experience of Prof. GUO Jun in the treatment of premature ejaculation. Beijing J Tradit Chin Med (Chin) 2013;11:848–849.

    Google Scholar 

  11. Wang F, Geng Q, Guo J, ZHANG Q, YU GJ, ZHAO JY, et al. Randomized and controlled clinical observation on acupuncture versus paroxetine in the treatment for primary premature ejaculation. Chin J Human Sex (Chin) 2013;2:59–61.

    CAS  Google Scholar 

  12. Mirone V, Arcaniolo D, Rivas D, Bull S, Aquilina JW, Verze P, et al. Results from a prospective observational study of men with premature ejaculation treated with dapoxetine or alternative care: the PAUSE study. Eur Urol 2014;65:733–739.

    Article  PubMed  Google Scholar 

  13. Hatzimouratidis K, Amar E, Eardley I, Giuliano F, Hatzichristou D, Montorsi F, et al. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. Eur Urol 2010;57:804–814.

    Article  PubMed  Google Scholar 

  14. Gupta RK1, Möller HJ. St. John's Wort. An option for the primary care treatment of depressive patients? Eur Arch Psych Clin Neurosci 2003;253:140–148.

    Article  CAS  Google Scholar 

  15. Zhang P, Chen DL, Lin L, Lin H, Deng T, Wu JS. Effects of Radix Morindae Officinalis Decoction on contents of monoamine neurotransmitters in brain tissues of natural aging mice. J Med Res (Chin) 2014;43:79–81.

    Google Scholar 

  16. Li YL, Zhang SL, Zhang LY, Song YL. Effect of Radix Paeoniae Alba Decoction on brain neurotransmitters in chronic stress depression rats. Zhejiang J Tradit Chin Med (Chin) 2012;47:912–913.

    Google Scholar 

  17. Xie TT, Wang H, Liu P, Wang DX. The influence of Acorus tatarinowii Schott on level of 5-hydroxytryptamine in brain. Chin J Drug Appl Monit (Chin) 2007;4:15–17.

    CAS  Google Scholar 

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Acknowledgments

No funding bodies played any role in study design, data collection and analysis, decision to publish, or preparation of this manuscript.

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Authors and Affiliations

  1. Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China

    Jun Guo  (郭 军), Qing-he Gao  (高庆和), Fu Wang  (王 福), Guo-jin Yu  (余国今), Ji-wei Zhang  (张继伟) & Yin Zeng  (曾 银)

  2. Department of Andrology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China

    Qiang Geng  (耿 强)

  3. Xiangya School of Medicine, Central South University, Changsha, 410013, China

    Bo-da Guo  (郭博达)

  4. Department of Andrology, Beijing Traditional Chinese Medicine Hospital Affilliated to Capital Medical University, Beijing, 100010, China

    Qiang Han  (韩 强)

Authors
  1. Jun Guo  (郭 军)
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  2. Qing-he Gao  (高庆和)
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  3. Fu Wang  (王 福)
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  4. Guo-jin Yu  (余国今)
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  5. Ji-wei Zhang  (张继伟)
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  6. Yin Zeng  (曾 银)
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  7. Qiang Geng  (耿 强)
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  8. Bo-da Guo  (郭博达)
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  9. Qiang Han  (韩 强)
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Corresponding author

Correspondence to Fu Wang  (王 福).

Additional information

Supported by the National Natural Science Foundation of China (No. 81273930)

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Guo, J., Gao, Qh., Wang, F. et al. Efficacy and safety of Qiaoshao Formula (翘芍方) on patients with lifelong premature ejaculation of Gan (Liver) depression and Shen (Kidney) deficiency syndrome: A randomized controlled trial. Chin. J. Integr. Med. 22, 889–893 (2016). https://doi.org/10.1007/s11655-016-2456-7

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  • DOI: https://doi.org/10.1007/s11655-016-2456-7

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