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Gastric Bypass and Sleeve Gastrectomy: the Same Impact on IL-6 and TNF-α. Prospective Clinical Trial

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Abstract

Background

Due to the association between the quantity of adipose tissue and concentrations of interleukin-6 (IL-6) and tumor necrosis factor (TNF-α), this work aimed to assess the effects of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) procedures on serum IL-6 and TNF-α concentrations.

Methods

This study evaluated serum IL-6 and TNF-α levels, as well as routine anthropometric and biochemical values, before and 1 year post-bariatric surgery. Fifty percent of patients (n = 24) underwent RYGB, and 50 % (n = 24) underwent SG. Prior to bariatric surgery, IL-6 and TNF-α mRNA expression levels in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were investigated in obese women.

Results

There was a significant reduction (p < 0.05) in all anthropometric and routine biochemical measurements in patients in the RYGB and SG groups 1 year post-surgery. The serum concentrations of IL-6 and TNF-α were reduced following surgery in both groups (p < 0.05). No differences in the relative expression levels of IL-6 and TNF-α were found between SAT and VAT prior to bariatric surgery.

Conclusions

RYGB and SG procedures demonstrated a similar impact on adipokine levels in women 1 year post-surgery. Both techniques may improve the course of chronic diseases and the state of inflammation associated with obesity.

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Acknowledgments

We thank the members of the Laboratory of Experimental Hypertension of the Department of Physiological Sciences/UFES, the members of the NDI/UFES (Center of Infectious Diseases), the students of the Department of Morphofunctional Sciences—EMESCAM College of Health, as well as the employees of the Human Genome Center, Department of Genetics and Evolutionary Biology, Institute of Bioscience—University of Sao Paulo for their support in collecting and analyzing samples in their laboratory; Ms. Ilma O'Reilly for her voluntary contribution in monitoring the follow-up assessments; and the members of the Bariatric Surgery Program of the HUCAM/UFES, Cassiano Antonio Moraes University Hospital, Federal University of Espírito Santo for their logistical support. We gratefully thank all of the subjects who participated in this study.

Conflict of Interest

The authors declare that they have no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Physiological Sciences, Federal University of Espírito Santo, Rua Marechal Campos, 1468, Vitória, CEP: 29040-090, ES, Brazil

    Elaine Cristina Viana, Margareth Ribeiro Moyses, Gláucia Rodrigues de Abreu & Nazaré Souza Bissoli

  2. Biotechnology Graduate Program, Health Sciences Center, Federal University of Espírito Santo, Vitória, ES, Brazil

    Karine L. Araujo-Dasilio

  3. Department of Obesity Surgery, Federal University of Espírito Santo, Vitória, ES, Brazil

    Gustavo Peixoto Soares Miguel

  4. Department of Nutrition and Health, Federal University of Viçosa, Viçosa, MG, Brazil

    Josefina Bressan

  5. Center of Infectious Diseases, Federal University of Espírito Santo, Vitória, ES, Brazil

    Elenice Moreira Lemos

  6. Department of Surgery, Federal University of São Paulo—UNIFESP, Vila Mariana, SP, Brazil

    João Luiz Moreira Coutinho de Azevedo

  7. Department of Medical Clinic, Federal University of Espírito Santo, Vitória, ES, Brazil

    Perseu Seixas Carvalho

  8. Human Genome Center, Department of Genetics and Evolutive Biology, Institute of Bioscience, University of Sao Paulo—USP, São Paulo, ES, Brazil

    Maria Rita S. Passos-Bueno

  9. Department of Morfofunctional Sciences, EMESCAM College of Helth Sciences, Vitoria, ES, Brazil

    Flávia Imbroisi Valle Errera

  10. University Vila Velha, Boa Vista, Vila Velha, CEP: 29102-770, ES, Brazil

    Elaine Cristina Viana

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  1. Elaine Cristina Viana
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  3. Gustavo Peixoto Soares Miguel
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Correspondence to Elaine Cristina Viana.

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Viana, E.C., Araujo-Dasilio, K.L., Miguel, G.P.S. et al. Gastric Bypass and Sleeve Gastrectomy: the Same Impact on IL-6 and TNF-α. Prospective Clinical Trial. OBES SURG 23, 1252–1261 (2013). https://doi.org/10.1007/s11695-013-0894-2

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  • DOI: https://doi.org/10.1007/s11695-013-0894-2

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