Abstract
Breast cancer (BC) is one of the most common malignancies and the second leading cause of cancer deaths among women worldwide. This high rate of morbidity and mortality requires research on the antioxidant and anticancer agents that can specifically kill or inhibit cancer cells without affecting normal cells. Trichoderma fungus is a rich source of such agents and secondary metabolites. Therefore, in the current study, we aimed to examine the effect of Trichoderma longibrachiatum metabolite in BC. The findings of our study illustrated that this fungus metabolite could limit the ability of breast cancer cells to proliferate and stop their cell cycle. On the other hand, it induces apoptosis in these cells. Together, the results of the present study for the first time demonstrate that T. longibrachiatum metabolite can play an anticancer role in the treatment of breast cancer, and it may be used as a clinical drug for BC treatment.
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Data availability
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Abbreviations
- BC:
-
breast cancer
- PDB:
-
potato dextrose broth
- MTT:
-
3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
- DMSO:
-
Dimethyl Sulfoxide
- PBS:
-
Phosphate buffer solution
- PI:
-
Propidium iodide
- SD:
-
standard deviation
- ANOVA:
-
one-way analysis of variance
- 3PM:
-
Predictive Preventive Personalised Medicine
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We would like to acknowledge Shahid Bahonar University of Kerman, Kerman, Iran.
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All authors contributed to the study conception and design. Nasim Ebrahimi done Supervision, reviewing and editing. Farzane Aminmahani performed Supervision, reviewing and editing. Batul Sadeghi carried out Methodology, writing-original draft preparation and performed the Experimental work performance. Masoud Ghanaatian revised and edited the manuscript.
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Ebrahimi, N., Amirmahani, F., Sadeghi, B. et al. Trichoderma longibrachiatum derived metabolite as a potential source of anti‐breast‐cancer agent. Biologia 76, 1595–1601 (2021). https://doi.org/10.1007/s11756-021-00705-0
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DOI: https://doi.org/10.1007/s11756-021-00705-0