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FIT Testing: An Overview

  • Large Intestine (B Cash, Section Editor)
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Abstract

Colorectal cancer (CRC) is a common, but preventable, disease and is the second most common cause of cancer-related deaths in the U.S. CRC screening has proven effective at reducing both the incidence and mortality of this disease, using any of a number of screening tests available. The test options range from the least invasive and least expensive to more invasive and costly options. Fecal occult blood testing is the oldest, least expensive, and least invasive of these options and has evolved from the poorly sensitive standard guaiac test to the newer and diagnostically superior fecal immunochemical test (FIT) for hemoglobin. This article explores the evolutionary history of fecal occult blood testing, examines test performance characteristics among different FOBTs, and evaluates the role of the FIT in programmatic CRC screening.

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References

  1. Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 2012;62:220–41.

    Article  PubMed  Google Scholar 

  2. Simon JB. Occult blood screening for colorectal carcinoma: a critical review. Gastroenterology. 1985;88:820–37.

    PubMed  CAS  Google Scholar 

  3. Irons Jr GV, Kirsner JB. Routine chemical tests of the stool for occult blood: an evaluation. Am J Med Sci. 1965;249:247–60.

    Article  PubMed  CAS  Google Scholar 

  4. Greegor DH. Diagnosis of large-bowel cancer in the asymptomatic patient. JAMA. 1967;201:943–5.

    Article  PubMed  CAS  Google Scholar 

  5. Faivre J, Dancourt V, Lejeune C, Tazi MA, Lamour J, Gerard D, et al. Reduction in colorectal cancer mortality by fecal occult blood screening in a French controlled study. Gastroenterology. 2004;126:1674–80.

    Article  PubMed  Google Scholar 

  6. Hardcastle JD, Chamberlain JO, Robinson MH, Moss SM, Amar SS, Balfour TW, et al. Randomised controlled trial of faecal-occult-blood screening for colorectal cancer. Lancet. 1996;348:1472–7.

    Article  PubMed  CAS  Google Scholar 

  7. Kronborg O, Fenger C, Olsen J, Jorgensen OD, Sondergaard O. Randomised study of screening for colorectal cancer with faecal-occult-blood test. Lancet. 1996;348:1467–71.

    Article  PubMed  CAS  Google Scholar 

  8. Lindholm E, Brevinge H, Haglind E. Survival benefit in a randomized clinical trial of faecal occult blood screening for colorectal cancer. Br J Surg. 2008;95:1029–36.

    Article  PubMed  CAS  Google Scholar 

  9. Mandel JS, Bond JH, Church TR, Snover DC, Bradley GM, Schuman LM, et al. Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study. N Engl J Med. 1993;328:1365–71.

    Article  PubMed  CAS  Google Scholar 

  10. Nakama H, Zhang B, Abdul Fattah AS, Kamijo N. Does stool collection method affect outcomes in immunochemical fecal occult blood testing? Dis Colon Rectum. 2001;44:871–5.

    Article  PubMed  CAS  Google Scholar 

  11. Nakama H, Fattah AS, Zhang B, Kamijo N. Digital rectal examination sampling of stool is less predictive of significant colorectal pathology than stool passed spontaneously. Eur J Gastroenterol Hepatol. 2000;12:1235–8.

    Article  PubMed  CAS  Google Scholar 

  12. Zhang B, Nakama H, Fattah AS, Kamijo N. Lower specificity of occult-blood test on stool collected by digital rectal examination. Hepatogastroenterology. 2002;49:165–7.

    PubMed  Google Scholar 

  13. Fleisher M, Winawer SJ, Zauber AG, Smith C, Schwartz MK. Accuracy of fecal occult blood test interpretation. National Polyp Study Work Group. Ann Intern Med. 1991;114:875–6.

    Article  PubMed  CAS  Google Scholar 

  14. Niv Y. Fecal occult blood test–the importance of proper evaluation. J Clin Gastroenterol. 1990;12:393–5.

    Article  PubMed  CAS  Google Scholar 

  15. Selinger RR, Norman S, Dominitz JA. Failure of health care professionals to interpret fecal occult blood tests accurately. Am J Med. 2003;114:64–7.

    Article  PubMed  Google Scholar 

  16. Jaffe RM, Kasten B, Young DS, MacLowry JD. False-negative stool occult blood tests caused by ingestion of ascorbic acid (vitamin C). Ann Intern Med. 1975;83:824–6.

    Article  PubMed  CAS  Google Scholar 

  17. Barrows GH, Burton RM, Jarrett DD, Russell GG, Alford MD, Songster CL. Immunochemical detection of human blood in feces. Am J Clin Pathol. 1978;69:342–6.

    PubMed  CAS  Google Scholar 

  18. Songster CL, Barrows GH, Jarrett DD. Immunochemical detection of fecal occult blood–the fecal smear punch-disc test: a new non-invasive screening test for colorectal cancer. Cancer. 1980;45:1099–102.

    Article  PubMed  CAS  Google Scholar 

  19. Vellacott KD, Baldwin RW, Hardcastle JD. An immunofluorescent test for faecal occult blood. Lancet. 1981;1:18–9.

    Article  PubMed  CAS  Google Scholar 

  20. Williams JA, Hunter R, Smith M, Coles ME, Hubert TW, Thomas DW. Evaluation of an immunological test for occult bleeding from colorectal neoplasia. Aust N Z J Surg. 1982;52:617–21.

    Article  PubMed  CAS  Google Scholar 

  21. Rabeneck L, Rumble RB, Thompson F, Mills M, Oleschuk C, Whibley A, et al. Fecal immunochemical tests compared with guaiac fecal occult blood tests for population-based colorectal cancer screening. Can J Gastroenterol. 2012;26:131–47.

    PubMed  Google Scholar 

  22. Hol L, Wilschut JA, van Ballegooijen M, van Vuuren AJ, van der Valk H, Reijerink JC, et al. Screening for colorectal cancer: random comparison of guaiac and immunochemical faecal occult blood testing at different cut-off levels. Br J Cancer. 2009;100:1103–10.

    Article  PubMed  CAS  Google Scholar 

  23. van Rossum LG, van Rijn AF, Laheij RJ, van Oijen MG, Fockens P, van Krieken HH, et al. Random comparison of guaiac and immunochemical fecal occult blood tests for colorectal cancer in a screening population. Gastroenterology. 2008;135:82–90.

    Article  PubMed  Google Scholar 

  24. Park DI, Ryu S, Kim YH, Lee SH, Lee CK, Eun CS, et al. Comparison of guaiac-based and quantitative immunochemical fecal occult blood testing in a population at average risk undergoing colorectal cancer screening. Am J Gastroenterol. 2010;105:2017–25.

    Article  PubMed  Google Scholar 

  25. van Dam L, Kuipers EJ, van Leerdam ME. Performance improvements of stool-based screening tests. Best Pract Res Clin Gastroenterol. 2010;24:479–92.

    Article  PubMed  Google Scholar 

  26. Parra-Blanco A, Gimeno-Garcia AZ, Quintero E, Nicolas D, Moreno SG, Jimenez A, et al. Diagnostic accuracy of immunochemical versus guaiac faecal occult blood tests for colorectal cancer screening. J Gastroenterol. 2010;45:703–12.

    Article  PubMed  CAS  Google Scholar 

  27. Cole SR, Young GP. Effect of dietary restriction on participation in faecal occult blood test screening for colorectal cancer. Med J Aust. 2001;175:195–8.

    PubMed  CAS  Google Scholar 

  28. Quintero E, Castells A, Bujanda L, Cubiella J, Salas D, Lanas A, et al. Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening. N Engl J Med. 2012;366:697–706.

    Article  PubMed  CAS  Google Scholar 

  29. Vart G, Banzi R, Minozzi S. Comparing participation rates between immunochemical and guaiac faecal occult blood tests: a systematic review and meta-analysis. Prev Med. 2012;55:87–92.

    Article  PubMed  Google Scholar 

  30. Chiang TH, Lee YC, Tu CH, Chiu HM, Wu MS. Performance of the immunochemical fecal occult blood test in predicting lesions in the lower gastrointestinal tract. CMAJ. 2011;183:1474–81.

    Article  PubMed  Google Scholar 

  31. Lane JM, Chow E, Young GP, Good N, Smith A, Bull J, et al. Interval fecal immunochemical testing in a colonoscopic surveillance program speeds detection of colorectal neoplasia. Gastroenterology. 2010;139:1918–26.

    Article  PubMed  Google Scholar 

  32. Zauber AG, Lansdorp-Vogelaar I, Knudsen AB, Wilschut J, van Ballegooijen M, Kuntz KM. Evaluating test strategies for colorectal cancer screening: a decision analysis for the U.S. Preventive Services Task Force. Ann Intern Med. 2008;149:659–69.

    Article  PubMed  Google Scholar 

  33. Denters MJ, Deutekom M, Bossuyt PM, Stroobants AK, Fockens P, Dekker E. Lower risk of advanced neoplasia among patients with a previous negative result from a fecal test for colorectal cancer. Gastroenterology. 2012;142:497–504.

    Article  PubMed  Google Scholar 

  34. Crotta S, Segnan N, Paganin S, Dagnes B, Rosset R, Senore C. High rate of advanced adenoma detection in 4 rounds of colorectal cancer screening with the fecal immunochemical test. Clin Gastroenterol Hepatol. 2012;10:633–8.

    Article  PubMed  Google Scholar 

  35. Fraser CG, Allison JE, Halloran SP, Young GP. A proposal to standardize reporting units for fecal immunochemical tests for hemoglobin. J Natl Cancer Inst. 2012;104:810–4.

    Article  PubMed  CAS  Google Scholar 

  36. Allison JE, Fraser CG, Halloran SP, Young GP. Comparing fecal immunochemical tests: improved standardization is needed. Gastroenterology. 2012;142:422–4.

    Article  PubMed  Google Scholar 

  37. Fraser CG, Allison JE, Young GP, Halloran SP. Quantitation of hemoglobin improves fecal immunochemical tests for noninvasive screening. Clin Gastroenterol Hepatol. 2013;11:839–40.

    Article  PubMed  CAS  Google Scholar 

  38. Fraser CG, Allison JE, Young GP, Halloran SP. Newer fecal tests: opportunities for professionals in laboratory medicine. Clin Chem. 2012;58:963–5.

    Article  PubMed  CAS  Google Scholar 

  39. Hundt S, Haug U, Brenner H. Comparative evaluation of immunochemical fecal occult blood tests for colorectal adenoma detection. Ann Intern Med. 2009;150:162–9.

    Article  PubMed  Google Scholar 

  40. Levi Z, Rozen P, Hazazi R, Vilkin A, Waked A, Maoz E, et al. A quantitative immunochemical fecal occult blood test for colorectal neoplasia. Ann Intern Med. 2007;146:244–55.

    Article  PubMed  Google Scholar 

  41. Ciatto S, Martinelli F, Castiglione G, Mantellini P, Rubeca T, Grazzini G, et al. Association of FOBT-assessed faecal Hb content with colonic lesions detected in the Florence screening programme. Br J Cancer. 2007;96:218–21.

    Article  PubMed  CAS  Google Scholar 

  42. Digby J, Fraser CG, Carey FA, McDonald PJ, Strachan JA, Diament RH, et al. Faecal haemoglobin concentration is related to severity of colorectal neoplasia. J Clin Pathol. 2013;66:415–9.

    Article  PubMed  CAS  Google Scholar 

  43. van Rossum LG, van Rijn AF, Laheij RJ, van Oijen MG, Fockens P, Jansen JB, et al. Cutoff value determines the performance of a semi-quantitative immunochemical faecal occult blood test in a colorectal cancer screening programme. Br J Cancer. 2009;101:1274–81.

    Article  PubMed  Google Scholar 

  44. von Karsa L, Patnick J, Segnan N, Atkin W, Halloran S, Lansdorp-Vogelaar I, et al. European guidelines for quality assurance in colorectal cancer screening and diagnosis: overview and introduction to the full supplement publication. Endoscopy. 2013;45:51–9.

    Article  Google Scholar 

  45. Joseph DA, King JB, Miller JW, Richardson LC. Prevalence of colorectal cancer screening among adults–Behavioral Risk Factor Surveillance System, United States, 2010. MMWR Morb Mortal Wkly Rep. 2012;61(Suppl):51–6.

    PubMed  Google Scholar 

  46. Schoen RE, Pinsky PF, Weissfeld JL, Yokochi LA, Church T, Laiyemo AO, et al. Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. N Engl J Med. 2012;366:2345–57.

    Article  PubMed  CAS  Google Scholar 

  47. Segnan N, Armaroli P, Bonelli L, Risio M, Sciallero S, Zappa M, et al. Once-only sigmoidoscopy in colorectal cancer screening: follow-up findings of the Italian Randomized Controlled Trial–SCORE. J Natl Cancer Inst. 2011;103:1310–22.

    Article  PubMed  Google Scholar 

  48. Atkin WS, Edwards R, Kralj-Hans I, Wooldrage K, Hart AR, Northover JM, et al. Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial. Lancet. 2010;375:1624–33.

    Article  PubMed  Google Scholar 

  49. Zauber AG, Winawer SJ, O’Brien MJ, Lansdorp-Vogelaar I, van Ballegooijen M, Hankey BF, et al. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N Engl J Med. 2012;366:687–96.

    Article  PubMed  CAS  Google Scholar 

  50. Robertson DJ, Greenberg ER, Beach M, Sandler RS, Ahnen D, Haile RW, et al. Colorectal cancer in patients under close colonoscopic surveillance. Gastroenterology. 2005;129:34–41.

    Article  PubMed  Google Scholar 

  51. Mulder SA, van Soest EM, Dieleman JP, van Rossum LG, Ouwendijk RJ, van Leerdam ME, et al. Exposure to colorectal examinations before a colorectal cancer diagnosis: a case–control study. Eur J Gastroenterol Hepatol. 2010;22:437–43.

    Article  PubMed  Google Scholar 

  52. Brenner H, Chang-Claude J, Seiler CM, Rickert A, Hoffmeister M. Protection from colorectal cancer after colonoscopy: a population-based, case–control study. Ann Intern Med. 2011;154:22–30.

    Article  PubMed  Google Scholar 

  53. Brenner H, Haug U, Arndt V, Stegmaier C, Altenhofen L, Hoffmeister M. Low risk of colorectal cancer and advanced adenomas more than 10 years after negative colonoscopy. Gastroenterology. 2010;138:870–6.

    Article  PubMed  Google Scholar 

  54. Lakoff J, Paszat LF, Saskin R, Rabeneck L. Risk of developing proximal versus distal colorectal cancer after a negative colonoscopy: a population-based study. Clin Gastroenterol Hepatol. 2008;6:1117–21. quiz 1064.

    Article  PubMed  Google Scholar 

  55. Baxter NN, Goldwasser MA, Paszat LF, Saskin R, Urbach DR, Rabeneck L. Association of colonoscopy and death from colorectal cancer. Ann Intern Med. 2009;150:1–8.

    Article  PubMed  Google Scholar 

  56. Baxter NN, Warren JL, Barrett MJ, Stukel TA, Doria-Rose VP. Association between colonoscopy and colorectal cancer mortality in a US cohort according to site of cancer and colonoscopist specialty. J Clin Oncol. 2012;30:2664–9.

    Article  PubMed  Google Scholar 

  57. Singh H, Nugent Z, Demers AA, Kliewer EV, Mahmud SM, Bernstein CN. The reduction in colorectal cancer mortality after colonoscopy varies by site of the cancer. Gastroenterology. 2010;139:1128–37.

    Article  PubMed  Google Scholar 

  58. Pickhardt PJ, Nugent PA, Mysliwiec PA, Choi JR, Schindler WR. Location of adenomas missed by optical colonoscopy. Ann Intern Med. 2004;141:352–9.

    Article  PubMed  Google Scholar 

  59. Bressler B, Paszat LF, Vinden C, Li C, He J, Rabeneck L. Colonoscopic miss rates for right-sided colon cancer: a population-based analysis. Gastroenterology. 2004;127:452–6.

    Article  PubMed  Google Scholar 

  60. Lieberman DA, Weiss DG, Bond JH, Ahnen DJ, Garewal H, Chejfec G. Use of colonoscopy to screen asymptomatic adults for colorectal cancer. Veterans Affairs Cooperative Study Group 380. N Engl J Med. 2000;343:162–8.

    Article  PubMed  CAS  Google Scholar 

  61. Lieberman DA, Weiss DG. One-time screening for colorectal cancer with combined fecal occult-blood testing and examination of the distal colon. N Engl J Med. 2001;345:555–60.

    Article  PubMed  CAS  Google Scholar 

  62. Schoenfeld P, Cash B, Flood A, Dobhan R, Eastone J, Coyle W, et al. Colonoscopic screening of average-risk women for colorectal neoplasia. N Engl J Med. 2005;352:2061–8.

    Article  PubMed  CAS  Google Scholar 

  63. Imperiale TF, Wagner DR, Lin CY, Larkin GN, Rogge JD, Ransohoff DF. Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med. 2000;343:169–74.

    Article  PubMed  CAS  Google Scholar 

  64. Pohl H, Robertson DJ. Colorectal cancers detected after colonoscopy frequently result from missed lesions. Clin Gastroenterol Hepatol. 2010;8:858–64.

    Article  PubMed  Google Scholar 

  65. Pohl H, Srivastava A, Bensen SP, Anderson P, Rothstein RI, Gordon SR, et al. Incomplete polyp resection during colonoscopy-results of the complete adenoma resection (CARE) study. Gastroenterology. 2013;144:74–80 e1.

    Article  PubMed  Google Scholar 

  66. Fisher DA, Maple JT, Ben-Menachem T, Cash BD, Decker GA, Early DS, et al. Complications of colonoscopy. Gastrointest Endosc. 2011;74:745–52.

    Article  PubMed  Google Scholar 

  67. Zauber AG, Lansdorp-Vogelaar I, Knudsen AB, Wilschut J, van Ballegooijen M, Kuntz KM. Evaluating test strategies for colorectal cancer screening-age to begin, age to stop, and timing of screening intervals: a decision analysis of colorectal cancer screening for the U.S. preventive services task force from the cancer intervention and surveillance modeling network (CISNET) [Internet]. Rockville: Agency for Healthcare Research and Quality. 2009.

  68. Sharaf RN, Ladabaum U. Comparative effectiveness and cost-effectiveness of screening colonoscopy vs. sigmoidoscopy and alternative strategies. Am J Gastroenterol. 2013;108:120–32.

    Article  PubMed  Google Scholar 

  69. Dong MH, Kalmaz D, Savides TJ. Missed work related to mid-week screening colonoscopy. Dig Dis Sci. 2011;56:2114–9.

    Article  PubMed  Google Scholar 

  70. Ko CW, Riffle S, Shapiro JA, Saunders MD, Lee SD, Tung BY, et al. Incidence of minor complications and time lost from normal activities after screening or surveillance colonoscopy. Gastrointest Endosc. 2007;65:648–56.

    Article  PubMed  Google Scholar 

  71. Jonas DE, Russell LB, Sandler RS, Chou J, Pignone M. Value of patient time invested in the colonoscopy screening process: time requirements for colonoscopy study. Med Decis Making. 2008;28:56–65.

    Article  PubMed  Google Scholar 

  72. Jonas DE, Russell LB, Sandler RS, Chou J, Pignone M. Patient time requirements for screening colonoscopy. Am J Gastroenterol. 2007;102:2401–10.

    Article  PubMed  Google Scholar 

  73. Seeff LC, Manninen DL, Dong FB, Chattopadhyay SK, Nadel MR, Tangka FK, et al. Is there endoscopic capacity to provide colorectal cancer screening to the unscreened population in the United States? Gastroenterology. 2004;127:1661–9.

    Article  PubMed  Google Scholar 

  74. Levin TR. Colonoscopy capacity: can we build it? Will they come? Gastroenterology. 2004;127:1841–4.

    Article  PubMed  Google Scholar 

  75. Ladabaum U, Song K. Projected national impact of colorectal cancer screening on clinical and economic outcomes and health services demand. Gastroenterology. 2005;129:1151–62.

    Article  PubMed  Google Scholar 

  76. Allen JD, Barlow WE, Duncan RP, Egede LE, Friedman LS, Keating NL, et al. NIH state-of-the-science conference statement: enhancing use and quality of colorectal cancer screening. NIH Consens State Sci Statements. 2010;27:1–31.

    PubMed  Google Scholar 

  77. Benson VS, Patnick J, Davies AK, Nadel MR, Smith RA, Atkin WS. Colorectal cancer screening: a comparison of 35 initiatives in 17 countries. Int J Cancer. 2008;122:1357–67.

    Article  PubMed  CAS  Google Scholar 

  78. Macafee DA, Scholefield JH. Antagonist: population based endoscopic screening for colorectal cancer. Gut. 2003;52:323–6.

    Article  PubMed  CAS  Google Scholar 

  79. Screening for colorectal cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2008;149:627–37.

    Google Scholar 

  80. Qaseem A, Denberg TD, Hopkins Jr RH, Humphrey LL, Levine J, Sweet DE, et al. Screening for colorectal cancer: a guidance statement from the American College of Physicians. Ann Intern Med. 2012;156:378–86.

    Article  PubMed  Google Scholar 

  81. Rex DK, Johnson DA, Anderson JC, Schoenfeld PS, Burke CA, Inadomi JM. American College of Gastroenterology guidelines for colorectal cancer screening 2009 [corrected]. Am J Gastroenterol. 2009;104:739–50.

    Article  PubMed  Google Scholar 

  82. Allison JE, Sakoda LC, Levin TR, Tucker JP, Tekawa IS, Cuff T, et al. Screening for colorectal neoplasms with new fecal occult blood tests: update on performance characteristics. J Natl Cancer Inst. 2007;99:1462–70.

    Article  PubMed  Google Scholar 

  83. de Wijkerslooth TR, Stoop EM, Bossuyt PM, Meijer GA, van Ballegooijen M, van Roon AH, et al. Immunochemical fecal occult blood testing is equally sensitive for proximal and distal advanced neoplasia. Am J Gastroenterol. 2012;107:1570–8.

    Article  PubMed  Google Scholar 

  84. van Roon AH, Goede SL, van Ballegooijen M, van Vuuren AJ, Looman CW, Biermann K, et al. Random comparison of repeated faecal immunochemical testing at different intervals for population-based colorectal cancer screening. Gut. 2013;62:409–15.

    Article  PubMed  Google Scholar 

  85. Allison JE. The best screening test for colorectal cancer is the one that gets done well. Gastrointest Endosc. 2010;71:342–5.

    Article  PubMed  Google Scholar 

  86. Inadomi JM. Why you should care about screening flexible sigmoidoscopy. N Engl J Med. 2012;366:2421–2.

    Article  PubMed  CAS  Google Scholar 

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Lukejohn W. Day, Taft Bhuket, and James Allison declare that they have no conflict of interest.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, San Francisco General Hospital and Trauma Center, 1001 Potrero Avenue, 3D-5, San Francisco, CA, 94110, USA

    Lukejohn W. Day

  2. Division of Gastroenterology, Department of Medicine, Alameda Health System, Oakland, CA, USA

    Taft Bhuket

  3. Division of Gastroenterology, University of California, San Francisco, San Francisco, CA, USA

    James Allison

  4. Kaiser Permanente Northern California Division of Research, Oakland, CA, USA

    James Allison

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  1. Lukejohn W. Day
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  2. Taft Bhuket
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Day, L.W., Bhuket, T. & Allison, J. FIT Testing: An Overview. Curr Gastroenterol Rep 15, 357 (2013). https://doi.org/10.1007/s11894-013-0357-x

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