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Vascular Dysfunction in Mother and Offspring During Preeclampsia: Contributions from Latin-American Countries

  • Preeclampsia (VD Garovic, Section Editor)
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Abstract

Pregnancy is a physiologically stressful condition that generates a series of functional adaptations by the cardiovascular system. The impact of pregnancy on this system persists from conception beyond birth. Recent evidence suggests that vascular changes associated with pregnancy complications, such as preeclampsia, affect the function of the maternal and offspring vascular systems, after delivery and into adult life. Since the vascular system contributes to systemic homeostasis, defective development or function of blood vessels predisposes both mother and infant to future risk for chronic disease. These alterations in later life range from fertility problems to alterations in the central nervous system or immune system, among others. It is important to note that rates of morbi-mortality due to pregnancy complications including preeclampsia, as well as cardiovascular diseases, have a higher incidence in Latin-American countries than in more developed countries. Nonetheless, there is a lack both in the amount and impact of research conducted in Latin America. An impact, although smaller, can be seen when research in vascular disorders related to problems during pregnancy is analyzed. Therefore, in this review, information about preeclampsia and endothelial dysfunction generated from research groups based in Latin-American countries will be highlighted. We relate the need, as present in many other countries in the world, for increased effective regional and international collaboration to generate new data specific to our region on this topic.

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Acknowledgements

We would like to thank all research staff from the Red Iberoamericana de alteraciones Vasculares Asociadas a TRastornos del EMbarazo (RIVA-TREM). We appreciate Ms. Lee Rager for her editorial assistance in the preparation of this manuscript.

Funding

Carlos Escudero is financially supported by Fondecyt Regular 1140586, Fondequip EQM140104, DIUBB 166709 3/R, and GI 171709/VC. Carlos Galaviz-Hernandez is financially supported by CONACYT-México FOSISS 162338 and 162368. María P. Ramos is financially supported by SAF2014-56671-R.

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Authors and Affiliations

  1. Laboratory of Vascular Biology, Institute of Health Sciences and Health, Universidade Federal de Mato Grosso, Barra do Garcas, MT, Brazil

    Fernanda Regina Giachini & Victor Vitorino Lima

  2. Pharmacogenomics Academia, Instituto Politécnico Nacional-CIIDIR Durango, Durango, Mexico

    Carlos Galaviz-Hernandez & Martha Sosa-Macias

  3. Laboratorio de Biología de la Reproducción, IFIBIO Houssay-UBA-CONICET, Buenos Aires, Argentina

    Alicia E. Damiano & Nora Martinez

  4. Biochemistry and Molecular Biology, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain

    Marta Viana, Martin Alcala, María Calderón-Domínguez & María P. Ramos

  5. Grupo Reproducción, Departamento de Fisiologia, Facultad de Medicina Universidad de Antioquia, Medellin, Colombia

    Angela Cadavid & Julio Bueno

  6. Hospital Materno-Infantil de la Caja Nacional de Salud, La Paz, Bolivia

    Patricia Asturizaga

  7. Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, Ecuador

    Enrique Teran

  8. Universidad de Ciencias Médicas de La Habana, Havana, Cuba

    Sonia Clapes

  9. Magee-Womens Research Institute, Departments of Obstetrics, Gynecology and Reproductive Sciences, Epidemiology, and the Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA

    James M. Roberts

  10. Vascular Physiology Laboratory Group of Investigation in Tumor Angiogenesis (GIANT) Group of Research and Innovation in Vascular Health (GRIVAS Health) Basic Sciences Department Faculty of Sciences, Universidad del Bio-Bio, Chillan, Chile

    Carlos Escudero

  11. Departamento de Ciencias Biológicas, Facultad de Farmacia y Bioquimica, UBA, Buenos Aires, Argentina

    Alicia E. Damiano

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  1. Fernanda Regina Giachini
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  2. Carlos Galaviz-Hernandez
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  3. Alicia E. Damiano
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  4. Marta Viana
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  9. Martin Alcala
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  16. James M. Roberts
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  17. Carlos Escudero
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on behalf of RIVA-TREM

Contributions

This work was carried out as a full collaboration among all the authors. Carlos Escudero defined the research topic. Fernanda Regina Giachini and Victor Vitorino Lima conducted data analysis and epidemiology. Carlos Galaviz-Hernandez and Martha Sosa-Macias contributed with the diagnostic criteria section and drafted the article, as well as elaborated tables and epidemiology section figures. All authors contributed in the discussion and review of the manuscript. All authors approved the final version.

Corresponding author

Correspondence to Carlos Escudero.

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The authors declare no conflict of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.x

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This article is part of the Topical Collection on Preeclampsia

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Giachini, F.R., Galaviz-Hernandez, C., Damiano, A.E. et al. Vascular Dysfunction in Mother and Offspring During Preeclampsia: Contributions from Latin-American Countries. Curr Hypertens Rep 19, 83 (2017). https://doi.org/10.1007/s11906-017-0781-7

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  • DOI: https://doi.org/10.1007/s11906-017-0781-7

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