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The Role of Interleukin-10 in the Pathophysiology of Preeclampsia

  • Preeclampsia (VD Garovic, Section Editor)
  • Published:
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Abstract

Purpose of Review

The pathophysiology of preeclampsia is complex and not entirely understood. A key feature in preeclampsia development is an immunological imbalance that shifts the maternal immune response from one of tolerance towards one promoting chronic inflammation and endothelial dysfunction. As a key regulator of immunity, IL-10 not only has immunomodulatory activity, but also directly benefits vasculature and promotes successful cellular interactions at the maternal-fetal interface. Here we focus on the mechanisms by which the dysregulation of IL-10 may contribute to the pathophysiology of preeclampsia.

Recent Findings

Dysregulation of IL-10 has been demonstrated in various animal models of preeclampsia. Decreased IL-10 production in both placenta and peripheral blood mononuclear cells has been reported in human studies, but with inconsistent results.

Summary

The significance of IL-10 in preeclampsia has shifted from a key biomarker to one with therapeutic potential. As such, a better understanding of the role of this cytokine in the pathophysiology of preeclampsia is of paramount importance.

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Authors and Affiliations

  1. Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Hajrunisa Cubro & Vesna D. Garovic

  2. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

    Sonu Kashyap

  3. St. Olaf College, Northfield, MN, USA

    Meryl C. Nath

  4. Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA

    Allan W. Ackerman

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  1. Hajrunisa Cubro
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Cubro, H., Kashyap, S., Nath, M.C. et al. The Role of Interleukin-10 in the Pathophysiology of Preeclampsia. Curr Hypertens Rep 20, 36 (2018). https://doi.org/10.1007/s11906-018-0833-7

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