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Neurological Complications of Measles (Rubeola)

  • Neurology of Systemic Diseases (J. Biller, Section Editor)
  • Published:
Current Neurology and Neuroscience Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Owing to vaccine hesitancy, there has been a resurgence of measles infections in developed countries. Practitioners can expect to see an increase in patients with neurologic complications of measles. These devastating disorders include primary measles encephalitis, acute post measles encephalitis, subacute sclerosing panencephalitis (SSPE), and measles inclusion body encephalitis (MIBE).

Recent Findings

Although there are many unanswered questions regarding the neurologic complications of measles, recent advances have led to better understanding of the mechanism of the spread of measles within the nervous system, particularly the disruption of F protein function, which raises the possibility of treatment with fusion-inhibiting molecules.

Summary

Measles and its neurological complications are preventable and must be prevented. Neurologists must educate other clinicians and the public regarding the consequences of inadequate herd immunity to measles. More effective treatments for SSPE and MIBE may be available in the near future, but currently these remain lethal diseases.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Weisse ME. The fourth disease, 1900-2000. Lancet. 2001;357(9252):299–301. https://doi.org/10.1016/S0140-6736(00)03623-0.

    Article  CAS  PubMed  Google Scholar 

  2. Cherry JD, Lugo D. Measles virus. In: Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ, editors. Feigin and Cherry’s textbook of pediatric infectious diseases. 8th ed. Philadelphia: Elsevier; 2019. p. 1754–70.e8.

    Google Scholar 

  3. Tanaka M, Harada T. Koplik spots in measles. Postgrad Med J. 2019;95(1126):454. https://doi.org/10.1136/postgradmedj-2019-136739.

    Article  PubMed  Google Scholar 

  4. Wang CH. Image gallery: measles revival: Koplik’s spots. Br J Dermatol. 2019. https://doi.org/10.1111/bjd.18417.

  5. Teng SS, Chua CR, Chan YH, Ong GY. Identifying children with measles for isolation in a high-volume pediatric emergency department in Singapore. Pediatr Infect Dis J. 2019;38(12):1204–7. https://doi.org/10.1097/INF.0000000000002481.

    Article  PubMed  Google Scholar 

  6. Avramovich E, Indenbaum V, Haber M, Amitai Z, Tsifanski E, Farjun S, et al. Measles outbreak in a highly vaccinated population - Israel, July–August 2017. MMWR Morb Mortal Wkly Rep. 2018;67(42):1186–8. https://doi.org/10.15585/mmwr.mm6742a4.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Roose J, Rohaert C, Jadoul A, Folster-Holst R, van Gysel D. Modified measles: a diagnostic challenge. Acta Derm Venereol. 2018;98(2):289–90. https://doi.org/10.2340/00015555-2825.

    Article  PubMed  Google Scholar 

  8. Uren AM, Vasant BR, Judd D, Looke DFM, Henderson AJ, Jarvinen KAJ. Modified measles with an atypical presentation. Commun Dis Intell (2018). 2019;43. https://doi.org/10.33321/cdi.2019.43.26.

  9. Laboccetta AC, Tornay AS. Measles encephalitis. Report of 61 cases. Am J Dis Child. 1964;107:247–55.

    Article  CAS  Google Scholar 

  10. Aarli JA. Nervous complications of measles. Clinical manifestations and prognosis. Eur Neurol. 1974;12(2):79–93. https://doi.org/10.1159/000114607.

    Article  CAS  PubMed  Google Scholar 

  11. Johnson RT. Acute encephalitis. Clin Infect Dis. 1996;23(2):219–24; quiz 25-6. https://doi.org/10.1093/clinids/23.2.219.

    Article  CAS  PubMed  Google Scholar 

  12. Johnson RT, Griffin DE, Hirsch RL, Wolinsky JS, Roedenbeck S, Lindo de Soriano I, et al. Measles encephalomyelitis--clinical and immunologic studies. N Engl J Med. 1984;310(3):137–41. https://doi.org/10.1056/NEJM198401193100301.

    Article  CAS  PubMed  Google Scholar 

  13. Gendelman HE, Wolinsky JS, Johnson RT, Pressman NJ, Pezeshkpour GH, Boisset GF. Measles encephalomyelitis: lack of evidence of viral invasion of the central nervous system and quantitative study of the nature of demyelination. Ann Neurol. 1984;15(4):353–60. https://doi.org/10.1002/ana.410150409.

    Article  CAS  PubMed  Google Scholar 

  14. Kennedy CR, Webster AD. Measles encephalitis. N Engl J Med. 1984;311(5):330–1. https://doi.org/10.1056/NEJM198408023110514.

    Article  CAS  PubMed  Google Scholar 

  15. Moench TR, Griffin DE, Obriecht CR, Vaisberg AJ, Johnson RT. Acute measles in patients with and without neurological involvement: distribution of measles virus antigen and RNA. J Infect Dis. 1988;158(2):433–42. https://doi.org/10.1093/infdis/158.2.433.

    Article  CAS  PubMed  Google Scholar 

  16. Esolen LM, Takahashi K, Johnson RT, Vaisberg A, Moench TR, Wesselingh SL, et al. Brain endothelial cell infection in children with acute fatal measles. J Clin Invest. 1995;96(5):2478–81. https://doi.org/10.1172/JCI118306.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. McLean DM, Best JM, Smith PA, Larke RP, McNaughton GA. Viral infections of Toronto children during 1965: II. Measles encephalitis and other complications. Can Med Assoc J. 1966;94(17):905–10.

    CAS  PubMed  PubMed Central  Google Scholar 

  18. ter Meulen V, Muller D, Kackell Y, Katz M, Meyermann R. Isolation of infectious measles virus in measles encephalitis. Lancet. 1972;2(7788):1172–5. https://doi.org/10.1016/s0140-6736(72)92595-0.

    Article  PubMed  Google Scholar 

  19. Fisher DL, Defres S, Solomon T. Measles-induced encephalitis. QJM. 2015;108(3):177–82. https://doi.org/10.1093/qjmed/hcu113.

    Article  CAS  PubMed  Google Scholar 

  20. • Dawson JR. Cellular inclusions in cerebral lesions of lethargic encephalitis. Am J Pathol. 1933;9(1):7–16 The original description of the pathology of what is now known as SSPE.

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Van Bogaert L. Une leuco-encéphalite sclérosante subaiguë. J Neurol Neurosurg Psychiatry. 1945;8:101–20. https://doi.org/10.1136/jnnp.8.3-4.101.

    Article  PubMed Central  Google Scholar 

  22. •• Leong WY, Wilder-Smith AB. Measles resurgence in Europe: migrants and travellers are not the main drivers. J Epidemiol Glob Health. 2019;9(4):294–9. https://doi.org/10.2991/jegh.k.191007.001An important paper that emphasizes the importance of vaccine hesitancy, rather than immigration or travel, as the main driver of measles resurgence.

    Article  PubMed  Google Scholar 

  23. •• Quinn SC, Jamison AM, Freimuth VS. Measles outbreaks and public attitudes towards vaccine exemptions: some cautions and strategies for addressing vaccine hesitancy. Hum Vaccin Immunother. 2019:1–5. https://doi.org/10.1080/21645515.2019.1646578Helpful guidance for the practitioner in addressing vaccine hesitancy.

  24. Khetsuriani N, Sanadze K, Abuladze M, Tatishvili N. High risk of subacute sclerosing panencephalitis following measles outbreaks in Georgia. Clin Microbiol Infect. 2019. https://doi.org/10.1016/j.cmi.2019.10.035.

  25. •• Garg RK, Mahadevan A, Malhotra HS, Rizvi I, Kumar N, Uniyal R. Subacute sclerosing panencephalitis. Rev Med Virol. 2019;29(5):e2058. https://doi.org/10.1002/rmv.2058A comprehensive, up-to-date, and very well illustrated review of SSPE.

    Article  PubMed  Google Scholar 

  26. •• Watanabe S, Shirogane Y, Sato Y, Hashiguchi T, Yanagi Y. New insights into measles virus brain infections. Trends Microbiol. 2019;27(2):164–75. https://doi.org/10.1016/j.tim.2018.08.010A comprehensive and well-illustrated review of recent advances in the molecular biology of measles virus infection.

    Article  CAS  PubMed  Google Scholar 

  27. Garg RK, Kumar N, Rizvi I, Jain A, Jaipuriar RS, Sharma PK, et al. Case report: subacute sclerosing panencephalitis presenting as acute encephalitis. Am J Trop Med Hyg. 2019;101(1):260–2. https://doi.org/10.4269/ajtmh.19-0215.

    Article  PubMed  Google Scholar 

  28. Chakor RT, Santosh NS. Subacute sclerosing panencephalitis presenting as rapidly progressive young-onset dementia. J Pak Med Assoc. 2013;63(7):921–4.

    PubMed  Google Scholar 

  29. Beersma MF, Galama JM, Van Druten HA, Renier WO, Lucas CJ, Kapsenberg JG. Subacute sclerosing panencephalitis in The Netherlands--1976-1990. Int J Epidemiol. 1992;21(3):583–8. https://doi.org/10.1093/ije/21.3.583.

    Article  CAS  PubMed  Google Scholar 

  30. Jabbour JT, Duenas DA, Sever JL, Krebs HM, Horta-Barbosa L. Epidemiology of subacute sclerosing panencephalitis (SSPE). A report of the SSPE registry. JAMA. 1972;220(7):959–62.

    Article  CAS  Google Scholar 

  31. Jabbour JT, Garcia JH, Lemmi H, Ragland J, Duenas DA, Sever JL. Subacute sclerosing panencephalitis. A multidisciplinary study of eight cases. JAMA. 1969;207(12):2248–54. https://doi.org/10.1001/jama.207.12.2248.

    Article  CAS  PubMed  Google Scholar 

  32. Risk WS, Haddad FS. The variable natural history of subacute sclerosing panencephalitis: a study of 118 cases from the Middle East. Arch Neurol. 1979;36(10):610–4. https://doi.org/10.1001/archneur.1979.00500460044004.

    Article  CAS  PubMed  Google Scholar 

  33. Colpak AI, Erdener SE, Ozgen B, Anlar B, Kansu T. Neuro-ophthalmology of subacute sclerosing panencephalitis: two cases and a review of the literature. Curr Opin Ophthalmol. 2012;23(6):466–71. https://doi.org/10.1097/ICU.0b013e328358b196.

    Article  PubMed  Google Scholar 

  34. Tripathy K, Chawla R, Mittal K, Farmania R, Venkatesh P, Gulati S. Ophthalmic examination as a means to diagnose subacute sclerosing panencephalitis: an optical coherence tomography and ultrawide field imaging evaluation. Eye Vis (Lond). 2017;4:1. https://doi.org/10.1186/s40662-016-0066-2.

    Article  Google Scholar 

  35. Shah A, Babu R, Biswas J. Retinitis as the presenting feature of subacute sclerosing panencephalitis in an Indian male: a case report. Indian J Ophthalmol. 2018;66(10):1491–3. https://doi.org/10.4103/ijo.IJO_251_18.

    Article  Google Scholar 

  36. Sharma S, Chanana B, Gulati S, Venkatesh P, Singh S. Acute bilateral vision loss as the presenting feature of subacute sclerosing panencephalitis. Indian J Pediatr. 2009;76(9):952–3. https://doi.org/10.1007/s12098-009-0191-1.

    Article  PubMed  Google Scholar 

  37. Cole AJ, Henson JW, Roehrl MH, Frosch MP. Case records of the Massachusetts General Hospital. Case 24-2007. A 20-year-old pregnant woman with altered mental status. N Engl J Med. 2007;357(6):589–600. https://doi.org/10.1056/NEJMcpc079018.

    Article  CAS  PubMed  Google Scholar 

  38. Reyes AJ, Ramcharan K, Perot S, Giddings SL, Rampersad F, Gobin R. Subacute sclerosing panencephalitis causing rapidly progressive dementia and myoclonic jerks in a sexagenarian woman. Tremor Other Hyperkinet Mov (N Y). 2019;9. https://doi.org/10.7916/tohm.v0.680.

  39. •• Meza RM, Schulz H, Correa J, Rojas M, Lal V, Espay AJ. Teaching video neuroimages: slow periodic myoclonus in subacute sclerosing panencephalitis and fulminant Wilson disease. Neurology. 2019;93(14):e1410–e1. https://doi.org/10.1212/WNL.0000000000008206A very helpful video recording of the classic slow periodic myoclonus of SS PE.

    Article  PubMed  Google Scholar 

  40. Jovic NJ. Epilepsy in children with subacute sclerosing panencephalitis. Srp Arh Celok Lek. 2013;141(7–8):434–40. https://doi.org/10.2298/sarh1308434j.

    Article  PubMed  Google Scholar 

  41. Caksen H, Odabas D, Atas B. Seizures in a boy with subacute sclerosing panencephalitis during high-dose intrathecal interferon-alpha therapy. Pediatr Neurol. 2002;27(1):75. https://doi.org/10.1016/s0887-8994(02)00408-3.

    Article  PubMed  Google Scholar 

  42. Dunand AC, Jallon P. EEG-mediated diagnosis of an unusual presentation of SSPE. Clin Neurophysiol. 2003;114(4):737–9. https://doi.org/10.1016/s1388-2457(02)00306-1.

    Article  CAS  PubMed  Google Scholar 

  43. Dimova PS, Bojinova VS. Case of subacute sclerosing panencephalitis with atypical absences and myoclonic-atonic seizures as a first symptom. J Child Neurol. 2004;19(7):548–52.

    PubMed  Google Scholar 

  44. Aydin OF, Senbil N, Gurer YK. Nonconvulsive status epilepticus on electroencephalography in a case with subacute sclerosing panencephalitis. J Child Neurol. 2006;21(3):256–60. https://doi.org/10.2310/7010.2006.00056.

    Article  PubMed  Google Scholar 

  45. Malhotra HS, Garg RK, Naphade P. Cluster of partial motor seizures heralding the onset of hemimyoclonic subacute sclerosing panencephalitis. Mov Disord. 2012;27(8):958–9. https://doi.org/10.1002/mds.24951.

    Article  PubMed  Google Scholar 

  46. Serdaroglu G, Kutlu A, Tekgul H, Tutuncuoglu S. Subacute sclerosing panencephalitis: a case with fulminant course after ACTH. Pediatr Neurol. 2004;31(1):67–70. https://doi.org/10.1016/j.pediatrneurol.2003.12.019.

    Article  PubMed  Google Scholar 

  47. Caraballo RH, Fortini S, Reyes G, Carpio Ruiz A, Sanchez Fuentes SV, Ramos B. Epileptic spasms in clusters and associated syndromes other than West syndrome: a study of 48 patients. Epilepsy Res. 2016;123:29–35. https://doi.org/10.1016/j.eplepsyres.2016.03.006.

    Article  PubMed  Google Scholar 

  48. Bhattacharyya R, Mukherjee B, Bhattacharyya S. A case of early onset subacute sclerosing panencephalitis presented as juvenile myoclonic epilepsy. Indian J Psychol Med. 2017;39(6):803–7. https://doi.org/10.4103/0253-7176.219642.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Markand ON. Electroencephalography in diffuse encephalopathies. J Clin Neurophysiol. 1984;1(4):357–407.

    Article  CAS  Google Scholar 

  50. Martinovic Z. Periodic generalized bursts of fast waves in subacute sclerosing panencephalitis. Electroencephalogr Clin Neurophysiol. 1986;63(3):236–8. https://doi.org/10.1016/0013-4694(86)90090-8.

    Article  CAS  PubMed  Google Scholar 

  51. Sheth RD. Electroencephalogram in developmental delay: specific electroclinical syndromes. Semin Pediatr Neurol. 1998;5(1):45–51. https://doi.org/10.1016/s1071-9091(98)80018-1.

    Article  CAS  PubMed  Google Scholar 

  52. Yemisci M, Gurer G, Saygi S, Ciger A. Generalised periodic epileptiform discharges: clinical features, neuroradiological evaluation and prognosis in 37 adult patients. Seizure. 2003;12(7):465–72. https://doi.org/10.1016/s1059-1311(02)00351-5.

    Article  PubMed  Google Scholar 

  53. Cherian A, Sreedharan S, Raghavendra S, Nayak D, Radhakrishnan A. Periodic lateralized epileptiform discharges in fulminant form of SSPE. Can J Neurol Sci. 2009;36(4):524–6. https://doi.org/10.1017/s0317167100007952.

    Article  PubMed  Google Scholar 

  54. Demir N, Cokar O, Bolukbasi F, Demirbilek V, Yapici Z, Yalcinkaya C, et al. A close look at EEG in subacute sclerosing panencephalitis. J Clin Neurophysiol. 2013;30(4):348–56. https://doi.org/10.1097/WNP.0b013e31829ddcb6.

    Article  PubMed  Google Scholar 

  55. Jankowski MA, Gut W, Kantoch M. Radioimmunoassay of measles virus antibodies in SSPE. Acta Virol. 1982;26(6):481–7.

    CAS  PubMed  Google Scholar 

  56. Silva CA, Rio ME, Cruz C. Protein patterns of the cerebrospinal fluid of 30 patients with subacute sclerosing panencephalitis (SSPE). Acta Neurol Scand. 1981;63(4):255–66. https://doi.org/10.1111/j.1600-0404.1981.tb00779.x.

    Article  CAS  PubMed  Google Scholar 

  57. Mehta PD, Patrick BA, Thormar H. Measles-specific IgG in CSF and serum from patients with subacute sclerosing panencephalitis. Immunology. 1982;46(2):423–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  58. Mattson DH, Roos RP, Arnason BG. Isoelectric focusing of IgG eluted from multiple sclerosis and subacute sclerosing panencephalitis brains. Nature. 1980;287(5780):335–7. https://doi.org/10.1038/287335a0.

    Article  CAS  PubMed  Google Scholar 

  59. Alkan A, Korkmaz L, Sigirci A, Kutlu R, Yakinci C, Erdem G, et al. Subacute sclerosing panencephalitis: relationship between clinical stage and diffusion-weighted imaging findings. J Magn Reson Imaging. 2006;23(3):267–72. https://doi.org/10.1002/jmri.20518.

    Article  PubMed  Google Scholar 

  60. Praveen-kumar S, Sinha S, Taly AB, Jayasree S, Ravi V, Vijayan J, et al. Electroencephalographic and imaging profile in a subacute sclerosing panencephalitis (SSPE) cohort: a correlative study. Clin Neurophysiol. 2007;118(9):1947–54. https://doi.org/10.1016/j.clinph.2007.06.008.

    Article  CAS  PubMed  Google Scholar 

  61. Yuksel D, Diren B, Ulubay H, Altunbasak S, Anlar B. Neuronal loss is an early component of subacute sclerosing panencephalitis. Neurology. 2014;83(10):938–44. https://doi.org/10.1212/WNL.0000000000000749.

    Article  PubMed  Google Scholar 

  62. Lebon S, Maeder P, Maeder-Ingvar M, Poloni C, Mayor-Dubois C, Roulet-Perez E, et al. An initial MRI picture of limbic encephalitis in subacute sclerosing panencephalitis. Eur J Paediatr Neurol. 2011;15(6):544–6. https://doi.org/10.1016/j.ejpn.2011.05.001.

    Article  PubMed  Google Scholar 

  63. Yaramis A, Taskesen M. Brainstem involvement in subacute sclerosing panencephalitis. Turk J Pediatr. 2010;52(5):542–5.

    PubMed  Google Scholar 

  64. Sharma P, Singh D, Singh MK, Garg RK, Kohli N. Brainstem involvement in subacute sclerosing panencephalitis. Neurol India. 2011;59(2):273–5. https://doi.org/10.4103/0028-3886.79146.

    Article  PubMed  Google Scholar 

  65. Thomas M, Sivadasan A, Alexander M, Patil AK. Subacute sclerosing panencephalitis with bilateral inferior collicular hyperintensity on magnetic resonance imaging brain. Ann Indian Acad Neurol. 2012;15(4):329–31. https://doi.org/10.4103/0972-2327.104351.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Bale JF Jr. Subacute sclerosing panencephalitis: a preventable disease that needs to be prevented. Neurology. 2004;63(8):1352–3. https://doi.org/10.1212/01.wnl.0000145113.98245.01.

    Article  PubMed  Google Scholar 

  67. Huttenlocher PR, Mattson RH. Isoprinosine in subacute sclerosing panencephalitis. Neurology. 1979;29(6):763–71. https://doi.org/10.1212/wnl.29.6.763.

    Article  CAS  PubMed  Google Scholar 

  68. Panitch HS, Gomez-Plascencia J, Norris FH, Cantell K, Smith RA. Subacute sclerosing panencephalitis: remission after treatment with intraventricular interferon. Neurology. 1986;36(4):562–6. https://doi.org/10.1212/wnl.36.4.562.

    Article  CAS  PubMed  Google Scholar 

  69. Gascon G, Yamani S, Crowell J, Stigsby B, Nester M, Kanaan I, et al. Combined oral isoprinosine-intraventricular alpha-interferon therapy for subacute sclerosing panencephalitis. Brain Dev. 1993;15(5):346–55. https://doi.org/10.1016/0387-7604(93)90120-w.

    Article  CAS  PubMed  Google Scholar 

  70. Gascon GG. International consortium on subacute sclerosing P. Randomized treatment study of inosiplex versus combined inosiplex and intraventricular interferon-alpha in subacute sclerosing panencephalitis (SSPE): international multicenter study. J Child Neurol. 2003;18(12):819–27. https://doi.org/10.1177/088307380301801201.

    Article  PubMed  Google Scholar 

  71. Drysdale HC, Jones LF, Oppenheimer DR, Tomlinson AH. Measles inclusion-body encephalitis in a child with treated acute lymphoblastic leukaemia. J Clin Pathol. 1976;29(10):865–72. https://doi.org/10.1136/jcp.29.10.865.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Agamanolis DP, Tan JS, Parker DL. Immunosuppressive measles encephalitis in a patient with a renal transplant. Arch Neurol. 1979;36(11):686–90. https://doi.org/10.1001/archneur.1979.00500470056011.

    Article  CAS  PubMed  Google Scholar 

  73. Chadwick DW, Martin S, Buxton PH, Tomlinson AH. Measles virus and subacute neurological disease: an unusual presentation of measles inclusion body encephalitis. J Neurol Neurosurg Psychiatry. 1982;45(8):680–4. https://doi.org/10.1136/jnnp.45.8.680.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. McQuaid S, Cosby SL, Koffi K, Honde M, Kirk J, Lucas SB. Distribution of measles virus in the central nervous system of HIV-seropositive children. Acta Neuropathol. 1998;96(6):637–42. https://doi.org/10.1007/s004010050945.

    Article  CAS  PubMed  Google Scholar 

  75. Poon TP, Tchertkoff V, Win H. Subacute measles encephalitis with AIDS diagnosed by fine needle aspiration biopsy. A case report. Acta Cytol. 1998;42(3):729–33. https://doi.org/10.1159/000331835.

    Article  CAS  PubMed  Google Scholar 

  76. Roos RP, Graves MC, Wollmann RL, Chilcote RR, Nixon J. Immunologic and virologic studies of measles inclusion body encephalitis in an immunosuppressed host: the relationship to subacute sclerosing panencephalitis. Neurology. 1981;31(10):1263–70. https://doi.org/10.1212/wnl.31.10.1263.

    Article  CAS  PubMed  Google Scholar 

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  1. Mayo Clinic Children’s Center, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, MN, 55905, USA

    Marc C. Patterson

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Dr. Patterson reports the following relationships:

Consulting: Amicus, Actelion, IntraBio, Novartis, Orphazyme, Shire/Takeda, Vtesse (all related to lysosomal disease, except for Novartis - multiple sclerosis)

Research Funding: Amicus, Glycomine, Idorsia, Orphazyme, Shire (lysosomal disease, congenital disorders of glycosylation)

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Patterson, M.C. Neurological Complications of Measles (Rubeola). Curr Neurol Neurosci Rep 20, 2 (2020). https://doi.org/10.1007/s11910-020-1023-y

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