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Hypoglycemic Activity of Grifola frondosa Rich in Vanadium

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Abstract

The hypoglycemic activity of fermented mushroom of Grifola frondosa rich in vanadium (GFRV) was studied in this paper. Alloxan- and adrenalin-induced hyperglycemic mice were used in the study. The blood glucose and the HbA1c of the mice were analyzed respectively. After the mice were administered (ig) with GFRV, the blood glucose and the HbA1c of alloxan-induced hyperglycemic mice decreased (p < 0.05, p < 0.01) and ascension of blood glucose induced by adrenalin was inhibited (p < 0.01). Also, the bodyweight of the alloxan-induced hyperglycemic mice was increased gradually. In the fermented mushroom of G. frondosa, vanadium at lower doses in combination with G. frondosa induced significant decreases of the blood glucose and HbA1c levels in hyperglycemic mice.

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Acknowledgment

This project is supported by Science and Technology Program of Shandong Education Department of China (J08LH62).

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Authors and Affiliations

  1. College of Food and Bioengineering, Shandong Institute of Light Industry, Jinan, 250353, People’s Republic of China

    Bo Cui & Jingran Qu

  2. School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People’s Republic of China

    Linna Han

  3. College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People’s Republic of China

    Yingtao Lv

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  1. Bo Cui
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  2. Linna Han
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  4. Yingtao Lv
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Correspondence to Yingtao Lv.

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Cui, B., Han, L., Qu, J. et al. Hypoglycemic Activity of Grifola frondosa Rich in Vanadium. Biol Trace Elem Res 131, 186–191 (2009). https://doi.org/10.1007/s12011-009-8355-4

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  • DOI: https://doi.org/10.1007/s12011-009-8355-4

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