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RETRACTED ARTICLE: The Effect of Lead Acetate Toxicity on Experimental Male Albino Rat

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This article was retracted on 24 November 2012

Abstract

The toxic effect of Pb ion (lead acetate) was investigated using male albino rats, which was ingested at 1/20, 1/40, and 1/60 sublethal doses. Relative to normal control, the ingestion of Pb2+ induced significant stimulation in ALT and AST activity. In addition, total soluble protein and albumin contents of plasma were decreased, while the content of globulin was changed by the Pb2+ treatments. The cholinesterase activity was inhibited, but the activities of alkaline and acid phosphates as well as lactate dehydrogenase were stimulated as a result of lead acetate intoxication. These observations were gradually paralleled across the experiment dose of the three doses of intoxicated Pb2+. In the case of blood picture, Pb2+ ingestion significantly reduced the contents of hemoglobin and RBC count of intoxicated rat’s blood, while the plasma levels of T3 and T4 and blood WBC count were insignificantly decreased or unchanged. All results of the present study showed that the Pb2+ ingestion was more effective in the case of the high dose (1/20 LD50) than that of the low dose (1/60 LD50) ingestion relative to the normal healthy control. The results of the present work advice the need to avoid exposure of humans to the lead compound to avoid injurious hazard risk.

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Abbreviations

ALT:

Alanine aminotransferase

AST:

Aspartate aminotransferase

RBC:

Red blood cells

WBC:

White blood cells

T3:

Triiodothyronine

T4:

Tetraiodothyronine (thyroxin)

LDH:

Lactate dehydrogenase

Hb:

Hemoglobin

ROS:

Reactive oxygen species

DNA:

Deoxyribonucleic acid

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Acknowledgments

The authors would like to thank the management of the Faculty of Agriculture and Cairo University for the ongoing cooperation to support research and for providing the funds and facilities necessary to achieve the desired goals of the research.

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Authors and Affiliations

  1. Department of Economic Entomology and Pesticides, Faculty of Agriculture, Cairo University, Cairo, Egypt

    Nabil M Ibrahim, Esam A. Eweis & Yasmin E. Abdel-Mobdy

  2. Department of Biochemistry, Faculty of Agriculture, Cairo University, P.O. Box 12613, Gamma St., Giza, Cairo, Egypt

    Hossam Saad El-Beltagi

Authors
  1. Nabil M Ibrahim
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  2. Esam A. Eweis
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  3. Hossam Saad El-Beltagi
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  4. Yasmin E. Abdel-Mobdy
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Corresponding author

Correspondence to Hossam Saad El-Beltagi.

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This article has been retracted due to duplicate publication.

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Ibrahim, N.M., Eweis, E.A., El-Beltagi, H.S. et al. RETRACTED ARTICLE: The Effect of Lead Acetate Toxicity on Experimental Male Albino Rat. Biol Trace Elem Res 144, 1120–1132 (2011). https://doi.org/10.1007/s12011-011-9149-z

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  • DOI: https://doi.org/10.1007/s12011-011-9149-z

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