Skip to main content
SpringerLink
Log in

Adult neural stem cells, neurogenic niches, and cellular therapy

  • Published:
Stem Cell Reviews Aims and scope Submit manuscript

Abstract

Niches are specialized microenvironments that regulate stem cells activity. In the nervous system, during development, niches control neural stem cells (NSCs) maturation and the formation of the neuronal network. In the adult, neurogenesis occurs in discrete areas of the brain, the subventricular zone and the hippocampus, where neurogenic niches have been identified and characterized. These niches, an angiogenic and an astroglial niche, control NSCs self-renewal and differentiation. Although the molecular and cellular mechanisms underlying the interactions between NSCs and their environment remain to be elucidated, neurogenic niches share similar developmentally conserved pathways with other niches. It is hypothesized that neurogenic niches underlie the properties and functions of NSCs in the adult central nervous system. Hence, neurogenic niches may not only hold the key to our understanding of neurogenesis in the adult brain, but also of the developmental potential of adult NSCs, and their potential for cellular therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Watt FM, Hogan BL. Science 2000;287:1427–1430.

    PubMed  CAS  Google Scholar 

  2. Alvarez-Buylla A, Lim DA. Neuron 2004;41:683–686.

    PubMed  CAS  Google Scholar 

  3. Gross CG. Nat Rev Neurosci 2000;1:67–73.

    PubMed  CAS  Google Scholar 

  4. Taupin P, Gage FH. J Neurosci Res 2002;69:745–749.

    PubMed  CAS  Google Scholar 

  5. Bayer SA, Yackel JW, Puri PS. Science 1982;216:890–892.

    PubMed  CAS  Google Scholar 

  6. Cameron HA, Woolley CS, McEwen BS, Gould E. Neuroscience 1993;56:337–344.

    PubMed  CAS  Google Scholar 

  7. Corotto FS, Henegar JA, Maruniak JA. Neurosci Lett 1993;149:111–114.

    PubMed  CAS  Google Scholar 

  8. Luskin MB. Neuron 1993;11:173–189.

    PubMed  CAS  Google Scholar 

  9. Lois C, Alvarez-Buylla A. Science 1994;264:1145–1148.

    Google Scholar 

  10. Lois C, Garcia-Verdugo JM, Alvarez-Buylla A. Science 1996;271:978–981.

    PubMed  CAS  Google Scholar 

  11. Doetsch F, Alvarez-Buylla A. Proc Natl Acad Sci USA 1996;93:14,895–14,900.

    CAS  Google Scholar 

  12. Eriksson PS, Perfilieva E, Bjork-Eriksson T, et al. Nat Med 1998;4:1313–1317.

    PubMed  CAS  Google Scholar 

  13. Sanai N, Tramontin AD, Quinones-Hinojosa A, et al. Nature 2004;427:740–744.

    PubMed  CAS  Google Scholar 

  14. Gage FH. Science 2000;287:1433–1438.

    PubMed  CAS  Google Scholar 

  15. Reynolds BA, Weiss S. Science 1992;255:1707–1710.

    PubMed  CAS  Google Scholar 

  16. Gritti A, Parati EA, Cova L, et al. J Neurosci 1996;16:1091–1100.

    PubMed  CAS  Google Scholar 

  17. Gage FH, Coates PW, Palmer TD, et al. Proc Natl Acad Sci USA 1995;92:11,879–11,883.

    CAS  Google Scholar 

  18. Palmer TD, Takahashi J, Gage FH. Mol Cell Neurosci 1997;8:389–404.

    PubMed  CAS  Google Scholar 

  19. Seaberg RM, van der Kooy D. J Neurosci 2002;22:1784–1793.

    PubMed  CAS  Google Scholar 

  20. Bull ND, Bartlett PF. J Neurosci 2005;25:10,815–10,821.

    CAS  Google Scholar 

  21. Taupin P. Ann Acad Med Singapore 2006;35:814–820.

    PubMed  Google Scholar 

  22. Johansson CB, Momma S, Clarke DL, Risling M, Lendahl U, Frisen J. Cell 1999;96:25–34.

    PubMed  CAS  Google Scholar 

  23. Lendahl U, Zimmerman LB, McKay RD. Cell 1990;60:585–595.

    PubMed  CAS  Google Scholar 

  24. Morshead CM, Reynolds BA, Craig CG, et al. Neuron 1994;13:1071–1082.

    Google Scholar 

  25. Doetsch F, Caille I, Lim DA, Garcia-Verdugo JM, Alvarez-Buylla A. Cell 1999;97:703–716.

    PubMed  CAS  Google Scholar 

  26. Seri B, Garcia-Verdugo JM, McEwen BS, Alvarez-Buylla A. J Neurosci 2001;21:7153–7160.

    PubMed  CAS  Google Scholar 

  27. Filippov V, Kronenberg G, Pivneva T, et al. Mol Cell Neurosci 2003;23:373–382.

    PubMed  CAS  Google Scholar 

  28. Morshead CM, Garcia AD, Sofroniew MV, van Der Kooy D. Eur J Neurosci 2003;18:76–84.

    PubMed  Google Scholar 

  29. Imura T, Kornblum HI, Sofroniew MV. J Neurosci 2003;23:2824–2832.

    PubMed  CAS  Google Scholar 

  30. Garcia AD, Doan NB, Imura T, Bush TG, Sofroniew MV. Nat Neurosci 2004;7:1233–1241.

    PubMed  CAS  Google Scholar 

  31. Horner PJ, Power AE, Kempermann G, et al. J Neurosci 2000;20:2218–2228.

    PubMed  CAS  Google Scholar 

  32. Shihabuddin LS, Horner PJ, Ray J, Gage FH. J Neurosci 2000;20:8727–8735.

    PubMed  CAS  Google Scholar 

  33. Nishimura EK, Jordan SA, Oshima H, et al. Nature 2002;416:854–860.

    PubMed  CAS  Google Scholar 

  34. Hackney JA, Charbord P, Brunk BP, Stoeckert CJ, Lemischka IR, Moore KA. Proc Natl Acad Sci USA 2002;99:13,061–13,066.

    CAS  Google Scholar 

  35. Suda T, Arai F, Hirao A. Trends Immunol 2005;26:426–433.

    PubMed  CAS  Google Scholar 

  36. Rendl M, Lewis L, Fuchs E. PLoS Biol 2005;3:e331.

    Google Scholar 

  37. Martin MA, Bhatia M. Stem Cells Dev 2005;14:493–504.

    PubMed  CAS  Google Scholar 

  38. Gekas C, Dieterlen-Lievre F, Orkin SH, Mikkola HK. Dev Cell 2005;8:365–375.

    PubMed  CAS  Google Scholar 

  39. Wilson A, Trumpp A. Nat Rev Immunol 2006;6:93–106.

    PubMed  CAS  Google Scholar 

  40. Theise ND. Am J Physiol Gastrointest Liver Physiol 2006;290:G189-G193.

    PubMed  CAS  Google Scholar 

  41. Palmer TD, Willhoite AR, Gage FH. J Comp Neurol 2000;425:479–494.

    PubMed  CAS  Google Scholar 

  42. Shen Q, Goderie SK, Jin L, et al. Science 2004;304:1338–1340.

    PubMed  CAS  Google Scholar 

  43. Lim DA, Alvarez-Buylla A. Proc Natl Acad Sci USA 1999;96:7526–7531.

    PubMed  CAS  Google Scholar 

  44. Song H, Stevens CF, Gage FH. Nature 2002;417:39–44.

    PubMed  CAS  Google Scholar 

  45. Coultas L, Chawengsaksophak K, Rossant J. Nature 2005;438:937–945.

    PubMed  CAS  Google Scholar 

  46. Sun Y, Jin K, Childs JT, Xie L, Mao XO, Greenberg DA. Dev Biol 2006;289:329–335.

    PubMed  CAS  Google Scholar 

  47. Lyden D, Young AZ, Zagzag D, et al. Nature 1999;401:670–677.

    PubMed  CAS  Google Scholar 

  48. Capela A, Temple S. Neuron 2002;35:865–875.

    PubMed  Google Scholar 

  49. Conover JC, Doetsch F, Garcia-Verdugo JM, Gale NW, Yancopoulos GD, Alvarez-Buylla A. Nat Neurosci 2000;3:1091–1097.

    PubMed  CAS  Google Scholar 

  50. Brantley-Sieders DM, Chen J. Angiogenesis 2004;7:17–28.

    PubMed  CAS  Google Scholar 

  51. Taupin P, Ray J, Fischer WH, et al. Neuron 2000;28:385–397.

    PubMed  CAS  Google Scholar 

  52. Yasuhara O, Hanai K, Ohkubo I, Sasaki M, McGeer PL, Kimura H. Brain Res 1993;628:85–92.

    PubMed  CAS  Google Scholar 

  53. Gacko M, Chyczewski L, Chrostek L. Pol J Pathol 1999;50:83–86.

    PubMed  CAS  Google Scholar 

  54. Battista D, Ferrari CC, Gage FH, Pitossi FJ. Eur J Neurosci 2006;23:83–93.

    PubMed  Google Scholar 

  55. Yue Z, Jiang TX, Widelitz RB, Chuong CM. Nature 2005;438:1026–1029.

    PubMed  CAS  Google Scholar 

  56. Lim DA, Tramontin AD, Trevejo JM, Herrera DG, Garcia-Verdugo JM, Alvarez-Buylla A. Neuron 2000;28:713–726.

    PubMed  CAS  Google Scholar 

  57. Fan XT, Xu HW, Cai WQ, Yang H, Liu S. Neurosci. Lett 2004;366:107–111.

    PubMed  CAS  Google Scholar 

  58. Lai K, Kaspar BK, Gage FH, Schaffer DV. Nat Neurosci 2003;6:21–27. Erratum in: Nat Neurosci 2003;6:645.

    PubMed  CAS  Google Scholar 

  59. Lie DC, Colamarino SA, Song HJ, et al. Nature 2005;437:1370–1375.

    PubMed  CAS  Google Scholar 

  60. Ueki T, Tanaka M, Yamashita K, et al. J Neurosci 2003;23:11,732–11,740.

    CAS  Google Scholar 

  61. Ohlstein B, Kai T, Decotto E, Spradling A. Curr Opin Cell Biol 2004;16:693–699.

    PubMed  CAS  Google Scholar 

  62. Qian X, Shen Q, Goderie SK, et al. Neuron 2000;28:69–80.

    PubMed  CAS  Google Scholar 

  63. Liu X, Wang Q, Haydar TF, Bordey A. Nat Neurosci 2005;8:1179–1187.

    PubMed  CAS  Google Scholar 

  64. Hagg T. Trends Neurosci 2005;28:589–595.

    PubMed  CAS  Google Scholar 

  65. Ma DK, Ming GL, Song H. Curr Opin Neurobiol 2005;15:514–520.

    PubMed  CAS  Google Scholar 

  66. Wurmser AE, Nakashima K, Summers RG, et al. Nature 2004;430:350–356.

    PubMed  CAS  Google Scholar 

  67. Bjornson CR, Rietze RL, Reynolds BA, Magli MC, Vescovi AL. Science 1999;283:534–537.

    PubMed  CAS  Google Scholar 

  68. Galli R, Borello U, Gritti A, et al. Nat Neurosci 2000;3:986–991.

    PubMed  CAS  Google Scholar 

  69. Clarke DL, Johansson CB, Wilbertz J, et al. Science 2000;288:1660–1663.

    PubMed  CAS  Google Scholar 

  70. Rietze RL, Valcanis H, Brooker GF, Thomas T, Voss AK, Bartlett PF. Nature 2001;412:736–739.

    PubMed  CAS  Google Scholar 

  71. Liu Z, Martin LJ. J Neurotrauma 2004;21:1479–1499.

    PubMed  Google Scholar 

  72. Jackson KA, Mi T, Goodell MA. Proc Natl Acad Sci USA 1999;96:14,482–14,486.

    CAS  Google Scholar 

  73. Cao B, Zheng B, Jankowski RJ, et al. Nat Cell Biol 2003;5:640–646.

    PubMed  CAS  Google Scholar 

  74. Alessandri G, Pagano S, Bez A, et al. Lancet 2004;364:1872–1883.

    PubMed  CAS  Google Scholar 

  75. Ferrari G, Cusella-De Angelis G, Coletta M, et al. Science 1998;279:1528–1530.

    PubMed  CAS  Google Scholar 

  76. Orlic D, Kajstura J, Chimenti S, et al. Nature 2001;410:701–705.

    PubMed  CAS  Google Scholar 

  77. Corbel SY, Lee A, Yi L, et al. Nat Med 2003;9:1528–1532.

    PubMed  CAS  Google Scholar 

  78. Petersen BE, Bowen WC, Patrene KD, et al. Science 1999;284:1168–1170.

    PubMed  CAS  Google Scholar 

  79. Lagasse E, Connors H, Al-Dhalimy M, et al. Nat Med 2000;6:1229–1234.

    PubMed  CAS  Google Scholar 

  80. Alison MR, Poulsom R, Jeffery R, et al. Nature 2000;406:257.

    PubMed  CAS  Google Scholar 

  81. Eglitis MA, Mezey E. Proc Natl Acad Sci USA 1997;94:4080–4085.

    PubMed  CAS  Google Scholar 

  82. Brazelton TR, Rossi FM, Keshet GI, Blau HM. Science 2000;290:1775–1779.

    PubMed  CAS  Google Scholar 

  83. Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR. Science 2000;290:1779–1782.

    PubMed  CAS  Google Scholar 

  84. Woodbury D, Schwarz EJ, Prockop DJ, Black IB. J Neurosci Res 2000;61:364–370.

    PubMed  CAS  Google Scholar 

  85. Crain BJ, Tran SD, Mezey E. J Neurol Sci 2005;233:121–123.

    PubMed  CAS  Google Scholar 

  86. Toma JG, Akhavan M, Fernandes KJ, et al. Nat Cell Biol 2001;3:778–784.

    PubMed  CAS  Google Scholar 

  87. Joannides A, Gaughwin P, Schwiening C, et al. Lancet 2004;364:172–178.

    PubMed  CAS  Google Scholar 

  88. Weissman IL, Anderson DJ, Gage FH. Annu Rev Cell Dev Biol 2001;17:387–403.

    PubMed  CAS  Google Scholar 

  89. D’Amour KA, Gage FH. Nat Med 2002;8:213–214.

    PubMed  CAS  Google Scholar 

  90. Wurmser AE, Gage FH. Nature 2002;416:485–487.

    PubMed  CAS  Google Scholar 

  91. Mezey E. Stem Cells Dev 2004;13:147–152.

    PubMed  Google Scholar 

  92. Qu TY, Dong XJ, Sugaya I, Vaghani A, Pulido J, Sugaya K. Restor Neurol Neurosci 2004;22:459–468.

    PubMed  CAS  Google Scholar 

  93. Burns TC, Ortiz-Gonzalez XR, Gutierrez-Perez M, et al. Stem Cells 2006;24:1121–1127.

    PubMed  CAS  Google Scholar 

  94. Murasawa S, Kawamoto A, Horii M, Nakamori S, Asahara T. Arterioscler Thromb Vasc Biol 2005;25:1388–1394.

    PubMed  CAS  Google Scholar 

  95. Curtis MA, Penney EB, Pearson AG, et al. Proc Natl Acad Sci USA 2003;100:9023–9027.

    PubMed  CAS  Google Scholar 

  96. Tattersfield AS, Croon RJ, Liu YW, Kells AP, Faull RL, Connor B. Neurosci 2004;127:319–332.

    CAS  Google Scholar 

  97. Zhang RL, Zhang ZG, Zhang L, Chopp M. Neurosci 2001;105:33–41.

    CAS  Google Scholar 

  98. Jiang W, Gu W, Brannstrom T, Rosqvist R, Wester P. Stroke 2001;32:1201–1207.

    PubMed  CAS  Google Scholar 

  99. Parent JM, Vexler ZS, Gong C, Derugin N, Ferriero DM. Ann Neurol 2002;52:802–813.

    PubMed  Google Scholar 

  100. Li Y, Chen J, Chopp M. J Neurol Sci 2002;193:137–146.

    PubMed  Google Scholar 

  101. Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O. Nat Med 2002;8:963–970.

    PubMed  CAS  Google Scholar 

  102. Jin K, Sun Y, Xie L, et al. Mol Cell Neurosci 2003;24:171–89.

    PubMed  CAS  Google Scholar 

  103. Taupin P. Restor Neurol Neurosci 2006;24:9–15.

    PubMed  Google Scholar 

  104. Taupin P. Curr Neurovasc Res 2006;3:67–72.

    PubMed  Google Scholar 

  105. McGraw J, Hiebert GW, Steeves JD. J Neurosci Res 2001;63:109–115.

    PubMed  CAS  Google Scholar 

  106. Ribotta MG, Menet V, Privat A. Acta Neurochir Suppl 2004;89:87–92.

    PubMed  CAS  Google Scholar 

  107. McIntosh TK, Smith DH, Meaney DF, Kotapka MJ, Gennarelli TA, Graham DI. Lab Invest 1996;74:315–342.

    PubMed  CAS  Google Scholar 

  108. Ghirnikar RS, Lee YL, Eng LF. Neurochem Res 1998;23:329–340.

    PubMed  CAS  Google Scholar 

  109. Stoll G, Jander S, Schroeter M. Adv Exp Med Biol 2002;513:87–113.

    PubMed  CAS  Google Scholar 

  110. Schwartz M. J Cereb Blood Flow Metab 2003;23:385–394.

    PubMed  Google Scholar 

  111. Roy NS, Wang S, Jiang L, et al. Nat Med 2000;6:271–277.

    PubMed  CAS  Google Scholar 

  112. Palmer TD, Schwartz PH, Taupin P, Kaspar B, Stein SA, Gage FH. Nature 2001;411:42–43.

    PubMed  CAS  Google Scholar 

  113. Schwartz PH, Bryant PJ, Fuja TJ, Su H, O’Dowd DK, Klassen HJ. Neurosci Res 2003;74:838–851.

    CAS  Google Scholar 

  114. Pluchino S, Quattrini A, Brambilla E, et al. Nature 2003;422:688–694.

    PubMed  CAS  Google Scholar 

  115. Cummings BJ, Uchida N, Tamaki SJ, et al. Proc Natl Acad Sci USA 2005;102:14,069–14,074.

    CAS  Google Scholar 

  116. Quesenberry PJ, Colvin G, Abedi M. Exp Hematol 2005;33:9–19.

    PubMed  Google Scholar 

  117. Adams GB, Chabner KT, Alley IR, et al. Nature 2006;439:599–603.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Neuroscience Institute, Singapore

    Philippe Taupin PhD

  2. National University of Singapore, Singapore

    Philippe Taupin PhD

  3. Nanyang Technological University, Singapore

    Philippe Taupin PhD

Authors
  1. Philippe Taupin PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Philippe Taupin PhD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Taupin, P. Adult neural stem cells, neurogenic niches, and cellular therapy. Stem Cell Rev 2, 213–219 (2006). https://doi.org/10.1007/s12015-006-0049-0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12015-006-0049-0

Index Entries

Search

Navigation