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Lung as a Niche for Hematopoietic Progenitors

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Abstract

Platelets are released from megakaryocytes. The bone marrow has been proposed to be the major site where this process occurs. Lefrançais et al. (2017) using state-of-the-art techniques including two-photon microscopy, in vivo lineage-tracing technologies, and sophisticated lung transplants reveal that the lung is also a primary site for platelet biogenesis. Strikingly, lung megakaryocytes can completely reconstitute platelet counts in the blood in mice with thrombocytopenia. This study also shows that hematopoietic progenitors, with capacity to repopulate the bone marrow after irradiation, are present in the lungs. This work brings a novel unexpected role for the lung as a niche for hematopoiesis. The emerging knowledge from this research may be important for the treatment of several disorders.

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Acknowledgements

Alexander Birbrair is supported by a grant from Pró-reitoria de Pesquisa/Universidade Federal de Minas Gerais (PRPq/UFMG) (Edital 05/2016); Akiva Mintz is supported by the National Institute of Health (1R01CA179072-01A1) and by the American Cancer Society Mentored Research Scholar grant (124443-MRSG-13-121-01-CDD). We thank Rosa Maria Esteves Arantes for her useful comments.

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Authors and Affiliations

  1. Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

    Isabella Borges, Isadora Sena, Patrick Azevedo, Julia Andreotti, Viviani Almeida, Ana Paiva, Gabryella Santos, Daniel Guerra, Pedro Prazeres, Luiza Lousado Mesquita, Luanny Souto de Barros Silva, Caroline Leonel & Alexander Birbrair

  2. Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA

    Akiva Mintz

  3. Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA

    Alexander Birbrair

  4. Albert Einstein College of Medicine, Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Bronx, NY, USA

    Alexander Birbrair

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  1. Isabella Borges
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Correspondence to Alexander Birbrair.

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Borges, I., Sena, I., Azevedo, P. et al. Lung as a Niche for Hematopoietic Progenitors. Stem Cell Rev and Rep 13, 567–574 (2017). https://doi.org/10.1007/s12015-017-9747-z

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