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The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects

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Abstract

An association between a catechol-O-methyltransferase (COMT) Val156Met (rs4680) polymorphism and schizophrenia has been reported in the literature, although no conclusive outcomes have been attained. The aim of this study was to evaluate the association of the COMT Val108/158Met polymorphism with schizophrenia in a systematic review and meta-analysis. We performed a keyword search on PubMed and EBSCO databases. All English language case–control studies published up to April 2015 were selected. A total of 67 studies were selected for inclusion. The genotype distribution of subjects with schizophrenia was compared with healthy control subjects, using allelic, additive, dominant and recessive models. The pooled results from the meta-analysis (15,565 cases and 17,251 healthy subjects) after the elimination of heterogeneity showed an association between COMT Val108/158Met and schizophrenia [recessive model: OR 1.08 CI 95 % (1.01–1.15)]. We conducted subgroup analyses according to ethnicity. An association was observed in our Caucasian population in the additive model [OR 1.21 CI 95 % (1.06–1.37)] and in the recessive model [OR 1.21 CI 95 % (1.11–1.32)], but not in the allelic or dominant models. However, when we analysed our Asian population after the elimination of heterogeneity, no evidence of a significant association was found in any of the genetic models. Our analyses indicate that there is an association between COMT Val108/158Met and schizophrenia in the general population. Furthermore, in Caucasian populations, this risk could be increased.

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Acknowledgments

The collection of data and genotyping of subjects were performed thanks to the grant and support from CONACYT CB-2012-177459.

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Authors and Affiliations

  1. División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco, Mexico

    Thelma Beatriz González-Castro & Yazmin Hernández-Díaz

  2. División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, Mexico

    Isela Esther Juárez-Rojop

  3. Hospital General de Yajalón, Secretaría de Salud, Yajalón, Chiapas, Mexico

    María Lilia López-Narváez

  4. División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Ranchería Sur, Cuarta Sección, C.P. 86650, Comalcalco, Tabasco, Mexico

    Carlos Alfonso Tovilla-Zárate

  5. Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico, D. F., Mexico

    Ana Fresan

Authors
  1. Thelma Beatriz González-Castro
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  2. Yazmin Hernández-Díaz
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  3. Isela Esther Juárez-Rojop
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  5. Carlos Alfonso Tovilla-Zárate
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  6. Ana Fresan
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Corresponding author

Correspondence to Carlos Alfonso Tovilla-Zárate.

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González-Castro, T.B., Hernández-Díaz, Y., Juárez-Rojop, I.E. et al. The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects. Neuromol Med 18, 216–231 (2016). https://doi.org/10.1007/s12017-016-8392-z

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  • DOI: https://doi.org/10.1007/s12017-016-8392-z

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