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The Role of PTHrP in Pancreatic Beta-Cells and Implications for Diabetes Pathophysiology and Treatment

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Abstract

Diabetes is one of the fastest growing diseases worldwide, with an immense economic and health burden attached. It is now well accepted that a deficiency of functional insulin-producing pancreatic beta-cells is the main cause for all forms of diabetes. Several approaches are being taken to increase functional beta-cell mass. These include differentiation of new beta-cells from stem cells or progenitor cells, transdifferentiation of beta-cells from other mature cell types, as well as finding ways to enhance the function, proliferation, survival, and regeneration of preexisting beta-cells. This article enumerates on the role of parathyroid hormone-related protein (PTHrP) and its mode of action on pancreatic beta-cell function, proliferation, and survival in rodents as well as in human beta-cells. A further understanding of the mechanism of action of PTHrP and its role in the normal physiology and pathophysiology of the beta-cell will be important for its potential use in future as a therapeutic treatment for diabetes.

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Acknowledgments

This work was supported over the years by grants to RCV from the National Institutes of Health (DK078060 and DK068831), the Juvenile Diabetes Research Foundation (1-2008-46), and the American Diabetes Association (Junior Faculty Award). We acknowledge the IIDP/JDRF Basic Science Islet Distribution Programs for supplying human islets.

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Conflict of interest

Anaïs Mozar, Nagesha Guthalu Kondegowda, Ilana Pollack, Rafael Fenutria, and Rupangi C. Vasavada declare that they have no conflict of interest associated with this manuscript.

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This article does not contain any studies with human or animal subjects performed by the any of the authors.

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  1. Diabetes, Obesity and Metabolism Institute, The Icahn School of Medicine at Mount Sinai, Atran 5, 1 Gustave L. Levy Place, Box 1152, New York, NY, 10029, USA

    Anaïs Mozar, Nagesha Guthalu Kondegowda, Ilana Pollack, Rafael Fenutria & Rupangi C. Vasavada

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  1. Anaïs Mozar
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  2. Nagesha Guthalu Kondegowda
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Correspondence to Rupangi C. Vasavada.

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Anaïs Mozar and Nagesha Guthalu Kondegowda have contributed equally to this work.

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Mozar, A., Kondegowda, N.G., Pollack, I. et al. The Role of PTHrP in Pancreatic Beta-Cells and Implications for Diabetes Pathophysiology and Treatment. Clinic Rev Bone Miner Metab 12, 165–177 (2014). https://doi.org/10.1007/s12018-014-9168-3

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