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2020 Chinese guidelines for ultrasound malignancy risk stratification of thyroid nodules: the C-TIRADS

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Abstract

Thyroid nodules are very common all over the world, and China is no exception. Ultrasound plays an important role in determining the risk stratification of thyroid nodules, which is critical for clinical management of thyroid nodules. For the past few years, many versions of TIRADS (Thyroid Imaging Reporting and Data System) have been put forward by several institutions with the aim to identify whether nodules require fine-needle biopsy or ultrasound follow-up. However, no version of TIRADS has been widely adopted worldwide till date. In China, as many as ten versions of TIRADS have been used in different hospitals nationwide, causing a lot of confusion. With the support of the Superficial Organ and Vascular Ultrasound Group of the Society of Ultrasound in Medicine of the Chinese Medical Association, the Chinese-TIRADS that is in line with China’s national conditions and medical status was established based on literature review, expert consensus, and multicenter data provided by the Chinese Artificial Intelligence Alliance for Thyroid and Breast Ultrasound.

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References

  1. C. Durante, G. Grani, L. Lamartina, S. Filetti, S.J. Mandel, D.S. Cooper, The diagnosis and management of thyroid nodules: a review. JAMA 319(9), 914–924 (2018). https://doi.org/10.1001/jama.2018.0898

    Article  PubMed  Google Scholar 

  2. B.R. Haugen, E.K. Alexander, K.C. Bible, G.M. Doherty, S.J. Mandel, Y.E. Nikiforov, F. Pacini, G.W. Randolph, A.M. Sawka, M. Schlumberger, K.G. Schuff, S.I. Sherman, J.A. Sosa, D.L. Steward, R.M. Tuttle, L. Wartofsky, 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 26(1), 1–133 (2016). https://doi.org/10.1089/thy.2015.0020

    Article  PubMed  PubMed Central  Google Scholar 

  3. Z. Chen, W. Xu, Y. Huang, X. Jin, J. Deng, S. Zhu, H. Liu, S. Zhang, Y. Yu, Associations of noniodized salt and thyroid nodule among the Chinese population: a large cross-sectional study. Am. J. Clin. Nutr. 98(3), 684–692 (2013). https://doi.org/10.3945/ajcn.112.054353

    Article  CAS  PubMed  Google Scholar 

  4. J. Yin, C. Wang, Q. Shao, D. Qu, Z. Song, P. Shan, T. Zhang, J. Xu, Q. Liang, S. Zhang, J. Huang, Relationship between the Prevalence of Thyroid Nodules and Metabolic Syndrome in the Iodine-Adequate Area of Hangzhou, China: A Cross-Sectional and Cohort Study. Int J. Endocrinol. 2014, 675796 (2014). https://doi.org/10.1155/2014/675796

    Article  PubMed  PubMed Central  Google Scholar 

  5. W. Xu, Z. Chen, N. Li, H. Liu, L. Huo, Y. Huang, X. Jin, J. Deng, S. Zhu, S. Zhang, Y. Yu, Relationship of anthropometric measurements to thyroid nodules in a Chinese population. BMJ Open 5(12), e008452 (2015). https://doi.org/10.1136/bmjopen-2015-008452

    Article  PubMed  PubMed Central  Google Scholar 

  6. Y. Li, D. Teng, J. Ba, B. Chen, J. Du, L. He, X. Lai, X. Teng, X. Shi, Y. Li, H. Chi, E. Liao, C. Liu, L. Liu, G. Qin, Y. Qin, H. Quan, B. Shi, H. Sun, X. Tang, N. Tong, G. Wang, J.A. Zhang, Y. Wang, Y. Xue, L. Yan, J. Yang, L. Yang, Y. Yao, Z. Ye, Q. Zhang, L. Zhang, J. Zhu, M. Zhu, G. Ning, Y. Mu, J. Zhao, Z. Shan, W. Teng, Efficacy and safety of long-term universal salt iodization on thyroid disorders: epidemiological evidence from 31 provinces of Mainland China. Thyroid 30(4), 568–579 (2020). https://doi.org/10.1089/thy.2019.0067

    Article  CAS  PubMed  Google Scholar 

  7. American College of Radiology (ACR). Breast Imaging Reporting and Data System Atlas (BI-RADS Atlas), 1st edn. (American College of Radiology, Reston, VA, 1992)

    Google Scholar 

  8. E. Horvath, S. Majlis, R. Rossi, C. Franco, J.P. Niedmann, A. Castro, M. Dominguez, An ultrasonogram reporting system for thyroid nodules stratifying cancer risk for clinical management. J. Clin. Endocrinol. Metab. 94(5), 1748–1751 (2009). https://doi.org/10.1210/jc.2008-1724

    Article  CAS  PubMed  Google Scholar 

  9. J.Y. Park, H.J. Lee, H.W. Jang, H.K. Kim, J.H. Yi, W. Lee, S.H. Kim, A proposal for a thyroid imaging reporting and data system for ultrasound features of thyroid carcinoma. Thyroid 19(11), 1257–1264 (2009)

    Article  PubMed  Google Scholar 

  10. J.Y. Kwak, K.H. Han, J.H. Yoon, H.J. Moon, E.J. Son, S.H. Park, H.K. Jung, J.S. Choi, B.M. Kim, E.K. Kim, Thyroid imaging reporting and data system for US features of nodules: a step in establishing better stratification of cancer risk. Radiology 260(3), 892–899 (2011). https://doi.org/10.1148/radiol.11110206

    Article  PubMed  Google Scholar 

  11. G. Russ, C. Bigorgne, B. Royer, A. Rouxel, M. Bienvenu-Perrard, The Thyroid Imaging Reporting and Data System (TIRADS) for ultrasound of the thyroid. J. Radio. 92(7–8), 701–713 (2011). https://doi.org/10.1016/j.jradio.2011.03.022

    Article  CAS  Google Scholar 

  12. J.F. Sánchez, TI-RADS classifcation of thyroid nodules based on a score modifed according to ultrasound criteria for malignancy. Rev. Argent. Radiol. 78(3), 138–148 (2014)

    Google Scholar 

  13. A.R. Zayadeen, M. Abu-Yousef, K. Berbaum, JOURNAL CLUB: retrospective evaluation of ultrasound features of thyroid nodules to assess malignancy risk: a step toward TIRADS. AJR Am. J. Roentgenol. 207(3), 460–469 (2016). https://doi.org/10.2214/AJR.15.15121

    Article  PubMed  Google Scholar 

  14. D. Songsaeng, S. Soodchuen, P. Korpraphong, A. Suwanbundit, Siriraj thyroid imaging reporting and data system and its effcacy. Siriraj Med. J. 69(5), 262–267 (2017)

    Google Scholar 

  15. S.Y. Xu, W.W. Zhan, W.H. Wang, Evaluation of thyroid nodules by a scoring and categorizing method based on sonographic features. J. Ultrasound Med. 34(12), 2179–2185 (2015). https://doi.org/10.7863/ultra.14.11041

    Article  PubMed  Google Scholar 

  16. J.H. Shin, J.H. Baek, J. Chung, E.J. Ha, J.H. Kim, Y.H. Lee, H.K. Lim, W.J. Moon, D.G. Na, J.S. Park, Y.J. Choi, S.Y. Hahn, S.J. Jeon, S.L. Jung, D.W. Kim, E.K. Kim, J.Y. Kwak, C.Y. Lee, H.J. Lee, J.H. Lee, J.H. Lee, K.H. Lee, S.W. Park, J.Y. Sung, Korean Society of Thyroid Radiology, Korean Society of Radiology, Ultrasonography diagnosis and imaging-based management of thyroid nodules: revised Korean Society of Thyroid Radiology Consensus Statement and Recommendations. Korean J. Radio. 17(3), 370–395 (2016). https://doi.org/10.3348/kjr.2016.17.3.370

    Article  Google Scholar 

  17. G. Russ, S.J. Bonnema, M.F. Erdogan, C. Durante, R. Ngu, L. Leenhardt, European Thyroid Association Guidelines for Ultrasound Malignancy Risk Stratification of Thyroid Nodules in Adults: The EU-TIRADS. Eur. Thyroid J. 6(5), 225–237 (2017). https://doi.org/10.1159/000478927

    Article  PubMed  PubMed Central  Google Scholar 

  18. E.G. Grant, F.N. Tessler, J.K. Hoang, J.E. Langer, M.D. Beland, L.L. Berland, J.J. Cronan, T.S. Desser, M.C. Frates, U.M. Hamper, W.D. Middleton, C.C. Reading, L.M. Scoutt, A.T. Stavros, S.A. Teefey, Thyroid ultrasound reporting lexicon: white paper of the ACR Thyroid Imaging, Reporting and Data System (TIRADS) Committee. J. Am. Coll. Radiol. 12(12 Pt A), 1272–1279 (2015). https://doi.org/10.1016/j.jacr.2015.07.011

    Article  PubMed  Google Scholar 

  19. F.N. Tessler, W.D. Middleton, E.G. Grant, J.K. Hoang, L.L. Berland, S.A. Teefey, J.J. Cronan, M.D. Beland, T.S. Desser, M.C. Frates, L.W. Hammers, U.M. Hamper, J.E. Langer, C.C. Reading, L.M. Scoutt, A.T. Stavros, ACR Thyroid Imaging, Reporting and Data System (TI-RADS): white paper of the ACR TI-RADS Committee. J. Am. Coll. Radiol. 14(5), 587–595 (2017). https://doi.org/10.1016/j.jacr.2017.01.046

    Article  PubMed  Google Scholar 

  20. H. Gharib, E. Papini, J.R. Garber, D.S. Duick, R.M. Harrell, L. Hegedus, R. Paschke, R. Valcavi, P. Vitti, AACE/ACE/AME Task Force on Thyroid Nodules, American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules—2016 update. Endocr. Pract. 22(5), 622–639 (2016). https://doi.org/10.4158/EP161208.GL

    Article  PubMed  Google Scholar 

  21. E.J. Ha, D.G. Na, J.H. Baek, J.Y. Sung, J.H. Kim, S.Y. Kang, US fine-needle aspiration biopsy for thyroid malignancy: diagnostic performance of seven society guidelines applied to 2000 thyroid nodules. Radiology 287(3), 893–900 (2018). https://doi.org/10.1148/radiol.2018171074

    Article  PubMed  Google Scholar 

  22. J.H. Yoon, K. Han, E.K. Kim, H.J. Moon, J.Y. Kwak, Diagnosis and management of small thyroid nodules: a comparative study with six guidelines for thyroid nodules. Radiology 283(2), 560–569 (2017). https://doi.org/10.1148/radiol.2016160641

    Article  PubMed  Google Scholar 

  23. J.H. Yoon, H.S. Lee, E.K. Kim, H.J. Moon, J.Y. Kwak, Malignancy risk stratification of thyroid nodules: comparison between the thyroid imaging reporting and data system and the 2014 American Thyroid Association Management Guidelines. Radiology 278(3), 917–924 (2016). https://doi.org/10.1148/radiol.2015150056

    Article  PubMed  Google Scholar 

  24. S.M. Ha, H.S. Ahn, J.H. Baek, H.Y. Ahn, Y.J. Chung, B.Y. Cho, S.B. Park, Validation of three scoring risk-stratification models for thyroid nodules. Thyroid 27(12), 1550–1557 (2017). https://doi.org/10.1089/thy.2017.0363

    Article  PubMed  Google Scholar 

  25. M. Castellana, C. Castellana, G. Treglia, F. Giorgino, L. Giovanella, G. Russ, P. Trimboli, Performance of five ultrasound risk stratification systems in selecting thyroid nodules for FNA. J. Clin. Endocrinol. Metab. 105(5) (2020). https://doi.org/10.1210/clinem/dgz170

  26. G. Grani, L. Lamartina, V. Ascoli, D. Bosco, M. Biffoni, L. Giacomelli, M. Maranghi, R. Falcone, V. Ramundo, V. Cantisani, S. Filetti, C. Durante, Reducing the number of unnecessary thyroid biopsies while improving diagnostic accuracy: toward the “Right” TIRADS. J. Clin. Endocrinol. Metab. 104(1), 95–102 (2019). https://doi.org/10.1210/jc.2018-01674

    Article  PubMed  Google Scholar 

  27. S.J. Yoon, D.G. Na, H.Y. Gwon, W. Paik, W.J. Kim, J.S. Song, M.S. Shim, Similarities and differences between thyroid imaging reporting and data systems. AJR Am. J. Roentgenol. 213(2), W76–W84 (2019). https://doi.org/10.2214/AJR.18.20510

    Article  PubMed  Google Scholar 

  28. J.H. Yoon, H.S. Lee, E.K. Kim, H.J. Moon, V.Y. Park, J.Y. Kwak, Pattern-based vs. score-based guidelines using ultrasound features have different strengths in risk stratification of thyroid nodules. Eur. Radiol. (2020). https://doi.org/10.1007/s00330-020-06722-y

  29. Q. Zhang, J. Ma, W. Sun, L. Zhang, Comparison of diagnostic performance between the American College of Radiology Thyroid Imaging Reporting and Data System and American Thyroid Association Guidelines: a systematic review. Endocr. Pract. 26(5), 552–563 (2020). https://doi.org/10.4158/EP-2019-0237

    Article  PubMed  Google Scholar 

  30. S.J. Choi, W.K. Jeong, A.J. Jo, J.A. Choi, M.J. Kim, M. Lee, S.E. Jung, K.H. Do, H.S. Yong, S. Sheen, M. Choi, J.H. Baek, Methodology for developing evidence-based clinical imaging guidelines: joint recommendations by Korean Society of Radiology and National Evidence-Based Healthcare Collaborating Agency. Korean J. Radiol. 18(1), 208–216 (2017). https://doi.org/10.3348/kjr.2017.18.1.208

    Article  PubMed  PubMed Central  Google Scholar 

  31. D. Cosgrove, R. Barr, J. Bojunga, V. Cantisani, M.C. Chammas, M. Dighe, S. Vinayak, J.M. Xu, C.F. Dietrich, WFUMB guidelines and recommendations on the clinical use of ultrasound elastography: part 4. Thyroid. Ultrasound Med. Biol. 43(1), 4–26 (2017). https://doi.org/10.1016/j.ultrasmedbio.2016.06.022

    Article  PubMed  Google Scholar 

  32. D. Cosgrove, F. Piscaglia, J. Bamber, J. Bojunga, J.M. Correas, O.H. Gilja, A.S. Klauser, I. Sporea, F. Calliada, V. Cantisani, M. D’Onofrio, E.E. Drakonaki, M. Fink, M. Friedrich-Rust, J. Fromageau, R.F. Havre, C. Jenssen, R. Ohlinger, A. Saftoiu, F. Schaefer, C.F. Dietrich; Efsumb, EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 2: clinical applications. Ultraschall Med. 34(3), 238–253 (2013). https://doi.org/10.1055/s-0033-1335375

    Article  CAS  PubMed  Google Scholar 

  33. Q. Peng, C. Niu, Q. Zhang, M. Zhang, S. Chen, Q. Peng, Mummified thyroid nodules: conventional and contrast-enhanced ultrasound features. J. Ultrasound Med. 38(2), 441–452 (2019). https://doi.org/10.1002/jum.14712

    Article  PubMed  Google Scholar 

  34. F. Gu, L. Han, X. Yang, H. Liu, X. Li, K. Guo, Z. Zhao, X. Zhou, W. Luo, Value of time-intensity curve analysis of contrast-enhanced ultrasound in the differential diagnosis of thyroid nodules. Eur. J. Radiol. 105, 182–187 (2018). https://doi.org/10.1016/j.ejrad.2018.05.013

    Article  PubMed  Google Scholar 

  35. L. Leenhardt, M.F. Erdogan, L. Hegedus, S.J. Mandel, R. Paschke, T. Rago, G. Russ, 2013 European thyroid association guidelines for cervical ultrasound scan and ultrasound-guided techniques in the postoperative management of patients with thyroid cancer. Eur. Thyroid J. 2(3), 147–159 (2013). https://doi.org/10.1159/000354537

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. M.A. Kouvaraki, S.E. Shapiro, B.D. Fornage, B.S. Edeiken-Monro, S.I. Sherman, R. Vassilopoulou-Sellin, J.E. Lee, D.B. Evans, Role of preoperative ultrasonography in the surgical management of patients with thyroid cancer. Surgery 134(6), 946–954 (2003). https://doi.org/10.1016/s0039-6060(03)00424-0

    Article  PubMed  Google Scholar 

  37. P.J. Mazzaglia, Surgeon-performed ultrasound in patients referred for thyroid disease improves patient care by minimizing performance of unnecessary procedures and optimizing surgical treatment. World J. Surg. 34(6), 1164–1170 (2010). https://doi.org/10.1007/s00268-010-0402-y

    Article  PubMed  Google Scholar 

  38. A.E. Cox, S.O. LeBeau, Diagnosis and treatment of differentiated thyroid carcinoma. Radiol. Clin. North Am. 49(3), 453–462 (2011). https://doi.org/10.1016/j.rcl.2011.02.006

    Article  PubMed  Google Scholar 

  39. Z.W. Baloch, V.A. LiVolsi, Fine-needle aspiration of the thyroid: today and tomorrow. Best. Pract. Res Clin. Endocrinol. Metab. 22(6), 929–939 (2008)

    Article  PubMed  Google Scholar 

  40. R.H. Cobin, H. Gharib, D.A. Bergman, O.H. Clark, D.S. Cooper, G.H. Daniels, R.A. Dickey, D.S. Duick, J.R. Garber, I.D. Hay, J.S. Kukora, H.M. Lando, A.B. Schorr, M.A. Zeiger; Thyroid Carcinoma Task Force, AACE/AAES medical/surgical guidelines for clinical practice: management of thyroid carcinoma. American Association of Clinical Endocrinologists. American College of Endocrinology. Endocr. Pract. 7(3), 202–220 (2001)

    Article  CAS  PubMed  Google Scholar 

  41. M.J. Kim, E.K. Kim, S.I. Park, B.M. Kim, J.Y. Kwak, S.J. Kim, J.H. Youk, S.H. Park, US-guided fine-needle aspiration of thyroid nodules: indications, techniques, results. RadioGraphics 28(7), 1869–1886 (2008). https://doi.org/10.1148/rg.287085033

    Article  PubMed  Google Scholar 

  42. N. Nagarajan, E.B. Schneider, S.Z. Ali, M.A. Zeiger, M.T. Olson, How do liquid-based preparations of thyroid fine-needle aspiration compare with conventional smears? An analysis of 5475 specimens. Thyroid 25(3), 308–313 (2015). https://doi.org/10.1089/thy.2014.0394

    Article  PubMed  Google Scholar 

  43. H. Chang, E. Lee, H. Lee, J. Choi, A. Kim, B.H. Kim, Comparison of diagnostic values of thyroid aspiration samples using liquid-based preparation and conventional smear: one-year experience in a single institution. APMIS 121(2), 139–145 (2013). https://doi.org/10.1111/j.1600-0463.2012.02944.x

    Article  PubMed  Google Scholar 

  44. S. Vaccarella, S. Franceschi, F. Bray, C.P. Wild, M. Plummer, L. Dal Maso, Worldwide thyroid-cancer epidemic? The increasing impact of overdiagnosis. N. Engl. J. Med. 375(7), 614–617 (2016). https://doi.org/10.1056/NEJMp1604412

    Article  PubMed  Google Scholar 

  45. H.S. Ahn, H.J. Kim, H.G. Welch, Korea’s thyroid-cancer “epidemic”–screening and overdiagnosis. N. Engl. J. Med. 371(19), 1765–1767 (2014). https://doi.org/10.1056/NEJMp1409841

    Article  PubMed  Google Scholar 

  46. H.S. Ahn, H.G. Welch, South Korea’s thyroid-cancer “epidemic”—turning the tide. N. Engl. J. Med 373(24), 2389–2390 (2015). https://doi.org/10.1056/NEJMc1507622

    Article  CAS  PubMed  Google Scholar 

  47. C. La Vecchia, M. Malvezzi, C. Bosetti, W. Garavello, P. Bertuccio, F. Levi, E. Negri, Thyroid cancer mortality and incidence: a global overview. Int J. Cancer 136(9), 2187–2195 (2015). https://doi.org/10.1002/ijc.29251

    Article  CAS  PubMed  Google Scholar 

  48. J.J. Cronan, Thyroid nodules: is it time to turn off the US machines? Radiology 247(3), 602–604 (2008). https://doi.org/10.1148/radiol.2473072233

    Article  PubMed  Google Scholar 

  49. H. Lim, S.S. Devesa, J.A. Sosa, D. Check, C.M. Kitahara, Trends in thyroid cancer incidence and mortality in the United States, 1974–2013. JAMA 317(13), 1338–1348 (2017). https://doi.org/10.1001/jama.2017.2719

    Article  PubMed  PubMed Central  Google Scholar 

  50. C. La Vecchia, E. Negri, Thyroid cancer: the thyroid cancer epidemic—overdiagnosis or a real increase? Nat. Rev. Endocrinol. 13(6), 318–319 (2017). https://doi.org/10.1038/nrendo.2017.53

    Article  PubMed  Google Scholar 

  51. Y. Ito, A. Miyauchi, H. Oda, Low-risk papillary microcarcinoma of the thyroid: a review of active surveillance trials. Eur. J. Surg. Oncol. 44(3), 307–315 (2018). https://doi.org/10.1016/j.ejso.2017.03.004

    Article  CAS  PubMed  Google Scholar 

  52. G.C. Haser, R.M. Tuttle, H.K. Su, E.E. Alon, D. Bergman, V. Bernet, E. Brett, R. Cobin, E.H. Dewey, G. Doherty, L.L. Dos Reis, J. Harris, J. Klopper, S.L. Lee, R.A. Levine, S.J. Lepore, I. Likhterov, M.A. Lupo, J. Machac, J.I. Mechanick, S. Mehra, M. Milas, L.A. Orloff, G. Randolph, T.A. Revenson, K.J. Roberts, D.S. Ross, M.E. Rowe, R.C. Smallridge, D. Terris, R.P. Tufano, M.L. Urken, Active surveillance for papillary thyroid microcarcinoma: new challenges and opportunities for the health care system. Endocr. Pract. 22(5), 602–611 (2016). https://doi.org/10.4158/EP151065.RA

    Article  PubMed  PubMed Central  Google Scholar 

  53. S. Leboulleux, R.M. Tuttle, F. Pacini, M. Schlumberger, Papillary thyroid microcarcinoma: time to shift from surgery to active surveillance? Lancet Diabetes Endocrinol. 4(11), 933–942 (2016). https://doi.org/10.1016/S2213-8587(16)30180-2

    Article  PubMed  Google Scholar 

  54. Y. Ito, T. Uruno, K. Nakano, Y. Takamura, A. Miya, K. Kobayashi, T. Yokozawa, F. Matsuzuka, S. Kuma, K. Kuma, A. Miyauchi, An observation trial without surgical treatment in patients with papillary microcarcinoma of the thyroid. Thyroid 13(4), 381–387 (2003). https://doi.org/10.1089/105072503321669875

    Article  PubMed  Google Scholar 

  55. Y. Ito, A. Miyauchi, H. Inoue, M. Fukushima, M. Kihara, T. Higashiyama, C. Tomoda, Y. Takamura, K. Kobayashi, A. Miya, An observational trial for papillary thyroid microcarcinoma in Japanese patients. World J. Surg. 34(1), 28–35 (2010). https://doi.org/10.1007/s00268-009-0303-0

    Article  PubMed  Google Scholar 

  56. Y. Ito, A. Miyauchi, M. Kihara, T. Higashiyama, K. Kobayashi, A. Miya, Patient age is significantly related to the progression of papillary microcarcinoma of the thyroid under observation. Thyroid 24(1), 27–34 (2014). https://doi.org/10.1089/thy.2013.0367

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. L. Du, Y. Wang, X. Sun, H. Li, X. Geng, M. Ge, Y. Zhu, Thyroid cancer: trends in incidence, mortality and clinical-pathological patterns in Zhejiang Province, Southeast China. BMC Cancer 18(1), 291 (2018). https://doi.org/10.1186/s12885-018-4081-7

    Article  PubMed  PubMed Central  Google Scholar 

  58. S.H. Xie, J. Chen, B. Zhang, F. Wang, S.S. Li, C.H. Xie, L.A. Tse, J.Q. Cheng, Time trends and age-period-cohort analyses on incidence rates of thyroid cancer in Shanghai and Hong Kong. BMC Cancer 14, 975 (2014). https://doi.org/10.1186/1471-2407-14-975

    Article  PubMed  PubMed Central  Google Scholar 

  59. M.C. Frates, C.B. Benson, J.W. Charboneau, E.S. Cibas, O.H. Clark, B.G. Coleman, J.J. Cronan, P.M. Doubilet, D.B. Evans, J.R. Goellner, I.D. Hay, B.S. Hertzberg, C.M. Intenzo, R.B. Jeffrey, J.E. Langer, P.R. Larsen, S.J. Mandel, W.D. Middleton, C.C. Reading, S.I. Sherman, F.N. Tessler, Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. Radiology 237(3), 794–800 (2005)

    Article  PubMed  Google Scholar 

  60. AIUM practice parameter for the performance of a thyroid and parathyroid ultrasound examination. J. Ultrasound Med. 35(9), 1–11 (2016). https://doi.org/10.7863/ultra.35.9.1-c

  61. S. Edge, D. Byrd, C. Compton, A. Fritz, F. Greene, A. Trotti. AJCC Cancer Staging Manual, 7th edn. (Springer, New York, NY, 2010)

    Google Scholar 

  62. S. Yan, W. Zhan, J.Q. Zhou. Ultrasound of the Thyroid and Parathyroid Glands.1st edn. (Science and Technology Literature Publishing House, Beijing, 2009)

    Google Scholar 

  63. M.C. Chammas, H.J. Moon, E.K. Kim, Why do we have so many controversies in thyroid nodule Doppler US? Radiology 259(1), 304 (2011). https://doi.org/10.1148/radiol.10101830

    Article  PubMed  Google Scholar 

  64. P.S. Sidhu, V. Cantisani, C.F. Dietrich, O.H. Gilja, A. Saftoiu, E. Bartels, M. Bertolotto, F. Calliada, D.A. Clevert, D. Cosgrove, A. Deganello, M. D’Onofrio, F.M. Drudi, S. Freeman, C. Harvey, C. Jenssen, E.M. Jung, A.S. Klauser, N. Lassau, M.F. Meloni, E. Leen, C. Nicolau, C. Nolsoe, F. Piscaglia, F. Prada, H. Prosch, M. Radzina, L. Savelli, H.P. Weskott, H. Wijkstra, The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in non-hepatic applications: update 2017 (Long Version). Ultraschall Med. 39(2), e2–e44 (2018). https://doi.org/10.1055/a-0586-1107

    Article  PubMed  Google Scholar 

  65. H. Seo, D.G. Na, J.H. Kim, K.W. Kim, J.W. Yoon, Ultrasound-based risk stratification for malignancy in thyroid nodules: a four-tier categorization system. Eur. Radiol. 25(7), 2153–2162 (2015). https://doi.org/10.1007/s00330-015-3621-7

    Article  PubMed  Google Scholar 

  66. W.J. Moon, J.H. Baek, S.L. Jung, D.W. Kim, E.K. Kim, J.Y. Kim, J.Y. Kwak, J.H. Lee, J.H. Lee, Y.H. Lee, D.G. Na, J.S. Park, S.W. Park; Korean Society of Thyroid Radiology, Korean Society of Radiology, Ultrasonography and the ultrasound-based management of thyroid nodules: consensus statement and recommendations. Korean J. Radiol. 12(1), 1–14 (2011). https://doi.org/10.3348/kjr.2011.12.1.1

    Article  PubMed  PubMed Central  Google Scholar 

  67. M. Itani, R. Assaker, M. Moshiri, T.J. Dubinsky, M.K. Dighe, Inter-observer variability in the American College of Radiology Thyroid Imaging Reporting and Data System: in-depth analysis and areas for improvement. Ultrasound Med. Biol. 45(2), 461–470 (2019). https://doi.org/10.1016/j.ultrasmedbio.2018.09.026

    Article  PubMed  Google Scholar 

  68. J.K. Hoang, W.D. Middleton, A.E. Farjat, S.A. Teefey, N. Abinanti, F.J. Boschini, A.J. Bronner, N. Dahiya, B.S. Hertzberg, J.R. Newman, D. Scanga, R.C. Vogler, F.N. Tessler, Interobserver variability of sonographic features used in the American College of Radiology Thyroid Imaging Reporting and Data System. AJR Am. J. Roentgenol. 211(1), 162–167 (2018). https://doi.org/10.2214/AJR.17.19192

    Article  PubMed  Google Scholar 

  69. Z.T. Sahli, A.K. Sharma, J.K. Canner, F. Karipineni, O. Ali, S. Kawamoto, J.F. Hang, A. Mathur, S.Z. Ali, M.A. Zeiger, S. Sheth, TIRADS interobserver variability among indeterminate thyroid nodules: a single-institution study. J. Ultrasound Med. 38(7), 1807–1813 (2019). https://doi.org/10.1002/jum.14870

    Article  PubMed  Google Scholar 

  70. S.H. Kim, C.S. Park, S.L. Jung, B.J. Kang, J.Y. Kim, J.J. Choi, Y.I. Kim, J.K. Oh, J.S. Oh, H. Kim, S.H. Jeong, H.W. Yim, Observer variability and the performance between faculties and residents: US criteria for benign and malignant thyroid nodules. Korean J. Radiol. 11(2), 149–155 (2010). https://doi.org/10.3348/kjr.2010.11.2.149

    Article  PubMed  PubMed Central  Google Scholar 

  71. R. Chung, A.B. Rosenkrantz, G.L. Bennett, B. Dane, J.E. Jacobs, C. Slywotzky, P.N. Smereka, A. Tong, S. Sheth, Interreader concordance of the TI-RADS: impact of radiologist experience. AJR Am. J. Roentgenol. 214(5), 1152–1157 (2020). https://doi.org/10.2214/AJR.19.21913

    Article  PubMed  Google Scholar 

  72. Y. Ito, C. Tomoda, T. Uruno, Y. Takamura, A. Miya, K. Kobayashi, F. Matsuzuka, K. Kuma, A. Miyauchi, Papillary microcarcinoma of the thyroid: how should it be treated? World J. Surg. 28(11), 1115–1121 (2004)

    Article  PubMed  Google Scholar 

  73. G. Li, J. Lei, Q. Peng, K. Jiang, W. Chen, W. Zhao, Z. Li, R. Gong, T. Wei, J. Zhu, Lymph node metastasis characteristics of papillary thyroid carcinoma located in the isthmus: a single-center analysis. Medicine 96(24), e7143 (2017). https://doi.org/10.1097/MD.0000000000007143

    Article  PubMed  PubMed Central  Google Scholar 

  74. M. Andrioli, C. Carzaniga, L. Persani, Standardized ultrasound report for thyroid nodules: the endocrinologist’s viewpoint. Eur. Thyroid J. 2(1), 37–48 (2013). https://doi.org/10.1159/000347144

    Article  PubMed  PubMed Central  Google Scholar 

  75. S.Y. Hahn, B.K. Han, E.Y. Ko, J.H. Shin, E.S. Ko, Ultrasound findings of papillary thyroid carcinoma originating in the isthmus: comparison with lobe-originating papillary thyroid carcinoma. AJR Am. J. Roentgenol. 203(3), 637–642 (2014). https://doi.org/10.2214/AJR.13.10746

    Article  PubMed  Google Scholar 

  76. Y.J. Chai, S.J. Kim, J.Y. Choi, H. Koo do, K.E. Lee, Y.K: Youn, Papillary thyroid carcinoma located in the isthmus or upper third is associated with Delphian lymph node metastasis. World J. Surg. 38(6), 1306–1311 (2014). https://doi.org/10.1007/s00268-013-2406-x

    Article  PubMed  Google Scholar 

  77. M. Li, X.Y. Zhu, J. Lv, K. Lu, M.P. Shen, Z.L. Xu, Z.S. Wu, Risk factors for predicting central lymph node metastasis in papillary thyroid microcarcinoma (CN0): a study of 273 resections. Eur. Rev. Med Pharm. Sci. 21(17), 3801–3807 (2017)

    CAS  Google Scholar 

  78. D. Xiang, L. Xie, Y. Xu, Z. Li, Y. Hong, P. Wang, Papillary thyroid microcarcinomas located at the middle part of the middle third of the thyroid gland correlates with the presence of neck metastasis. Surgery 157(3), 526–533 (2015). https://doi.org/10.1016/j.surg.2014.10.020

    Article  PubMed  Google Scholar 

  79. J.Y. Kwak, E.K. Kim, M.J. Kim, E.J. Son, W.Y. Chung, C.S. Park, K.H. Nam, Papillary microcarcinoma of the thyroid: predicting factors of lateral neck node metastasis. Ann. Surg. Oncol. 16(5), 1348–1355 (2009). https://doi.org/10.1245/s10434-009-0384-x

    Article  PubMed  Google Scholar 

  80. W.X. Jin, Y.X. Jin, D.R. Ye, Z.C. Zheng, Y.H. Sun, X.F. Zhou, Q. Li, O.C. Wang, H.G. Liu, X.H. Zhang, Predictive factors of skip metastasis in papillary thyroid cancer. Med Sci. Monit. 24, 2744–2749 (2018). https://doi.org/10.12659/MSM.907357

    Article  PubMed  PubMed Central  Google Scholar 

  81. J. Lei, J. Zhu, Z. Li, R. Gong, T. Wei, Surgical procedures for papillary thyroid carcinoma located in the thyroid isthmus: an intention-to-treat analysis. Onco Targets Ther. 9, 5209–5216 (2016). https://doi.org/10.2147/OTT.S106837

    Article  PubMed  PubMed Central  Google Scholar 

  82. I. Vasileiadis, G. Boutzios, M. Karalaki, E. Misiakos, T. Karatzas, Papillary thyroid carcinoma of the isthmus: total thyroidectomy or isthmusectomy? Am. J. Surg. 216(1), 135–139 (2018). https://doi.org/10.1016/j.amjsurg.2017.09.008

    Article  PubMed  Google Scholar 

  83. F. Zhang, O. Oluwo, F.B. Castillo, P. Gangula, M. Castillo, F. Farag, S. Zakaria, T. Zahedi, Thyroid nodule location on ultrasonography as a predictor of malignancy. Endocr. Pract. 25(2), 131–137 (2019). https://doi.org/10.4158/EP-2018-0361

    Article  CAS  PubMed  Google Scholar 

  84. S. Jasim, T.J. Baranski, S.A. Teefey, W.D. Middleton, Investigating the effect of thyroid nodule location on the risk of thyroid cancer. Thyroid 30(3), 401–407 (2020). https://doi.org/10.1089/thy.2019.0478

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. V. Ramundo, L. Lamartina, R. Falcone, L. Ciotti, C. Lomonaco, M. Biffoni, L. Giacomelli, M. Maranghi, C. Durante, G. Grani, Is thyroid nodule location associated with malignancy risk? Ultrasonography 38(3), 231–235 (2019). https://doi.org/10.14366/usg.18050

    Article  PubMed  Google Scholar 

  86. E.K. Kim, C.S. Park, W.Y. Chung, K.K. Oh, D.I. Kim, J.T. Lee, H.S. Yoo, New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid. AJR Am. J. Roentgenol. 178(3), 687–691 (2002)

    PubMed  Google Scholar 

  87. W.J. Moon, S.L. Jung, J.H. Lee, D.G. Na, J.H. Baek, Y.H. Lee, J. Kim, H.S. Kim, J.S. Byun, D.H. Lee, Benign and malignant thyroid nodules: US differentiation—multicenter retrospective study. Radiology 247(3), 762–770 (2008)

    Article  PubMed  Google Scholar 

  88. Y.J. Choi, J.H. Baek, S.H. Baek, W.H. Shim, K.D. Lee, H.S. Lee, Y.K. Shong, E.J. Ha, J.H. Lee, Web-based malignancy risk estimation for thyroid nodules using ultrasonography characteristics: development and validation of a predictive model. Thyroid 25(12), 1306–1312 (2015). https://doi.org/10.1089/thy.2015.0188

    Article  PubMed  Google Scholar 

  89. H.J. Moon, J.Y. Kwak, E.K. Kim, M.J. Kim, A taller-than-wide shape in thyroid nodules in transverse and longitudinal ultrasonographic planes and the prediction of malignancy. Thyroid 21(11), 1249–1253 (2011). https://doi.org/10.1089/thy.2010.0372

    Article  PubMed  Google Scholar 

  90. S.K. Jeh, S.L. Jung, B.S. Kim, Y.S. Lee, Evaluating the degree of conformity of papillary carcinoma and follicular carcinoma to the reported ultrasonographic findings of malignant thyroid tumor. Korean J. Radiol. 8(3), 192–197 (2007). https://doi.org/10.3348/kjr.2007.8.3.192

    Article  PubMed  PubMed Central  Google Scholar 

  91. J.H. Yoon, E.K. Kim, S.W. Hong, J.Y. Kwak, M.J. Kim, Sonographic features of the follicular variant of papillary thyroid carcinoma. J. Ultrasound Med. 27(10), 1431–1437 (2008)

    PubMed  Google Scholar 

  92. S.P. Chen, Y.P. Hu, B. Chen, Taller-than-wide sign for predicting thyroid microcarcinoma: comparison and combination of two ultrasonographic planes. Ultrasound Med Biol. 40(9), 2004–2011 (2014). https://doi.org/10.1016/j.ultrasmedbio.2014.03.023

    Article  PubMed  Google Scholar 

  93. C.Y. Lee, S.J. Kim, K.R. Ko, K.W. Chung, J.H. Lee, Predictive factors for extrathyroidal extension of papillary thyroid carcinoma based on preoperative sonography. J. Ultrasound Med. 33(2), 231–238 (2014). https://doi.org/10.7863/ultra.33.2.231

    Article  PubMed  Google Scholar 

  94. W.J. Moon, S.L. Jung, J.H. Lee, D.G. Na, J.H. Baek, Y.H. Lee, J. Kim, H.S. Kim, J.S. Byun, D.H. Lee; Thyroid Study Group, Korean Society of Neuro- and Head and Neck Radiology, Benign and malignant thyroid nodules: US differentiation–multicenter retrospective study. Radiology 247(3), 762–770 (2008). https://doi.org/10.1148/radiol.2473070944

    Article  PubMed  Google Scholar 

  95. D.M. Richman, C.B. Benson, P.M. Doubilet, H.E. Peters, S.A. Huang, E. Asch, A.J. Wassner, J.R. Smith, C.E. Cherella, M.C. Frates, Thyroid nodules in pediatric patients: sonographic characteristics and likelihood of cancer. Radiology 288(2), 591–599 (2018). https://doi.org/10.1148/radiol.2018171170

    Article  PubMed  Google Scholar 

  96. L.R. Remonti, C.K. Kramer, C.B. Leitao, L.C. Pinto, J.L. Gross, Thyroid ultrasound features and risk of carcinoma: a systematic review and meta-analysis of observational studies. Thyroid 25(5), 538–550 (2015). https://doi.org/10.1089/thy.2014.0353

    Article  PubMed  PubMed Central  Google Scholar 

  97. G. Anil, A. Hegde, F.H. Chong, Thyroid nodules: risk stratification for malignancy with ultrasound and guided biopsy. Cancer Imaging 11, 209–223 (2011). https://doi.org/10.1102/1470-7330.2011.0030

    Article  PubMed  PubMed Central  Google Scholar 

  98. V. Ramundo, C.R.T. Di Gioia, R. Falcone, L. Lamartina, M. Biffoni, L. Giacomelli, S. Filetti, C. Durante, G. Grani, Diagnostic performance of neck ultrasonography in the preoperative evaluation for extrathyroidal extension of suspicious thyroid nodules. World J. Surg. (2020). https://doi.org/10.1007/s00268-020-05482-6

  99. M.C. Chammas, R. Gerhard, I.R. de Oliveira, A. Widman, N. de Barros, M. Durazzo, A. Ferraz, G.G. Cerri, Thyroid nodules: evaluation with power Doppler and duplex Doppler ultrasound. Otolaryngol. Head. Neck Surg. 132(6), 874–882 (2005)

    PubMed  Google Scholar 

  100. W.H. Yuan, H.J. Chiou, Y.H. Chou, H.C. Hsu, C.M. Tiu, C.Y. Cheng, C.H. Lee, Gray-scale and color Doppler ultrasonographic manifestations of papillary thyroid carcinoma: analysis of 51 cases. Clin. Imaging 30(6), 394–401 (2006)

    PubMed  Google Scholar 

  101. R.L.C. Delfim, L. Veiga, A.P.A. Vidal, F. Lopes, M. Vaisman, P. Teixeira, Likelihood of malignancy in thyroid nodules according to a proposed Thyroid Imaging Reporting and Data System (TI-RADS) classification merging suspicious and benign ultrasound features. Arch. Endocrinol. Metab. 61(3), 211–221 (2017). https://doi.org/10.1590/2359-3997000000262

    Article  PubMed  Google Scholar 

  102. W.J. Moon, H.J. Kwag, D.G. Na, Are there any specific ultrasound findings of nodular hyperplasia (“leave me alone” lesion) to differentiate it from follicular adenoma? Acta Radiol. 50(4), 383–388 (2009). https://doi.org/10.1080/02841850902740940

    Article  PubMed  Google Scholar 

  103. E. Koike, S. Noguchi, H. Yamashita, T. Murakami, A. Ohshima, H. Kawamoto, H. Yamashita, Ultrasonographic characteristics of thyroid nodules: prediction of malignancy. Arch. Surg. 136(3), 334–337 (2001)

    CAS  PubMed  Google Scholar 

  104. B.K. Chan, T.S. Desser, I.R. McDougall, R.J. Weigel, R.B. Jeffrey Jr, Common and uncommon sonographic features of papillary thyroid carcinoma. J. Ultrasound Med. 22(10), 1083–1090 (2003)

    PubMed  Google Scholar 

  105. J.Z. Zhang, B. Hu, Sonographic features of thyroid follicular carcinoma in comparison with thyroid follicular adenoma. J. Ultrasound Med. 33(2), 221–227 (2014). https://doi.org/10.7863/ultra.33.2.221

    Article  PubMed  Google Scholar 

  106. A. Lyshchik, V. Drozd, Y. Demidchik, C. Reiners, Diagnosis of thyroid cancer in children: value of gray-scale and power doppler US. Radiology 235(2), 604–613 (2005)

    PubMed  Google Scholar 

  107. A.M. Tahvildari, L. Pan, C.S. Kong, T. Desser, Sonographic-pathologic correlation for punctate echogenic reflectors in papillary thyroid carcinoma: what are they? J. Ultrasound Med. 35(8), 1645–1652 (2016). https://doi.org/10.7863/ultra.15.09048

    Article  PubMed  Google Scholar 

  108. H.Y. Gwon, D.G. Na, B.J. Noh, W. Paik, S.J. Yoon, S.J. Choi, D.R. Shin, Thyroid nodules with isolated macrocalcifications: malignancy risk of isolated macrocalcifications and postoperative risk stratification of malignant tumors manifesting as isolated macrocalcifications. Korean J. Radiol. 21(5), 605–613 (2020). https://doi.org/10.3348/kjr.2019.0523

    Article  PubMed  PubMed Central  Google Scholar 

  109. H. Malhi, M.D. Beland, S.Y. Cen, E. Allgood, K. Daley, S.E. Martin, J.J. Cronan, E.G. Grant, Echogenic foci in thyroid nodules: significance of posterior acoustic artifacts. AJR Am. J. Roentgenol. 203(6), 1310–1316 (2014). https://doi.org/10.2214/AJR.13.11934

    Article  PubMed  Google Scholar 

  110. A. Ahuja, W. Chick, W. King, C. Metreweli, Clinical significance of the comet-tail artifact in thyroid ultrasound. J. Clin. Ultrasound 24(3), 129–133 (1996)

    Article  CAS  PubMed  Google Scholar 

  111. D.T. Ginat, D. Butani, E.J. Giampoli, N. Patel, V. Dogra, Pearls and pitfalls of thyroid nodule sonography and fine-needle aspiration. Ultrasound Q. 26(3), 171–178 (2010). https://doi.org/10.1097/RUQ.0b013e3181efa710

    Article  PubMed  Google Scholar 

  112. K. Klang, A. Kamaya, A.M. Tahvildari, R.B. Jeffrey, T.S. Desser, Atypical thyroid cancers on sonography. Ultrasound Q. 31(1), 69–74 (2015). https://doi.org/10.1097/RUQ.0000000000000079

    Article  PubMed  Google Scholar 

  113. H. Wu, B. Zhang, J. Li, Q. Liu, T. Zhao, Echogenic foci with comet-tail artifact in resected thyroid nodules: not an absolute predictor of benign disease. PLoS ONE 13(1), e0191505 (2018). https://doi.org/10.1371/journal.pone.0191505

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  114. M.D. Beland, L. Kwon, R.A. Delellis, J.J. Cronan, E.G. Grant, Nonshadowing echogenic foci in thyroid nodules: are certain appearances enough to avoid thyroid biopsy? J. Ultrasound Med. 30(6), 753–760 (2011)

    Article  PubMed  Google Scholar 

  115. B. Mallikarjunappa, S.R. Ashish, Ultrasound evaluation of thyroid nodules and its pathological correlation. JIMSA Jan. 27(1), 9–11 (2014)

    Google Scholar 

  116. D.W. Kim, Sonographic features of thyroidal fatty lesions in the thyroid gland: a preliminary study. AJR Am. J. Roentgenol. 207(2), 411–414 (2016). https://doi.org/10.2214/AJR.15.15984

    Article  PubMed  Google Scholar 

  117. Q.S. Li, S.H. Chen, H.H. Xiong, X.H. Xu, Z.Z. Li, G.Q. Guo, Papillary thyroid carcinoma on sonography. Clin. Imaging 34(2), 121–126 (2010). https://doi.org/10.1016/j.clinimag.2009.03.003

    Article  PubMed  Google Scholar 

  118. H. Ota, Y. Ito, F. Matsuzuka, S. Kuma, S. Fukata, S. Morita, K. Kobayashi, Y. Nakamura, K. Kakudo, N. Amino, A. Miyauchi, Usefulness of ultrasonography for diagnosis of malignant lymphoma of the thyroid. Thyroid 16(10), 983–987 (2006)

    Article  PubMed  Google Scholar 

  119. Y. Ito, N. Amino, A. Miyauchi, Thyroid ultrasonography. World J. Surg. 34(6), 1171–1180 (2010). https://doi.org/10.1007/s00268-009-0211-3

    Article  PubMed  Google Scholar 

  120. H.J. Lee, D.Y. Yoon, Y.L. Seo, J.H. Kim, S. Baek, K.J. Lim, Y.K. Cho, E.J. Yun, Intraobserver and Interobserver variability in ultrasound measurements of thyroid nodules. J. Ultrasound Med. 37(1), 173–178 (2018). https://doi.org/10.1002/jum.14316

    Article  PubMed  Google Scholar 

  121. J.Y. Kwak, I. Jung, J.H. Baek, S.M. Baek, N. Choi, Y.J. Choi, S.L. Jung, E.K. Kim, J.A. Kim, J.H. Kim, K.S. Kim, J.H. Lee, J.H. Lee, H.J. Moon, W.J. Moon, J.S. Park, J.H. Ryu, J.H. Shin, E.J. Son, J.Y. Sung, D.G. Na, Korean Society of Thyroid Radiology, Korean Society of Radiology, Image reporting and characterization system for ultrasound features of thyroid nodules: multicentric Korean retrospective study. Korean J. Radiol. 14(1), 110–117 (2013). https://doi.org/10.3348/kjr.2013.14.1.110

    Article  PubMed  Google Scholar 

  122. S.H. Choi, E.K. Kim, J.Y. Kwak, M.J. Kim, E.J. Son, Interobserver and intraobserver variations in ultrasound assessment of thyroid nodules. Thyroid 20(2), 167–172 (2010). https://doi.org/10.1089/thy.2008.0354

    Article  PubMed  Google Scholar 

  123. H.K. Su, L.L. Dos Reis, M.A. Lupo, M. Milas, L.A. Orloff, J.E. Langer, E.M. Brett, E. Kazam, S.L. Lee, G. Minkowitz, E.H. Alpert, E.H. Dewey, M.L. Urken, Striving toward standardization of reporting of ultrasound features of thyroid nodules and lymph nodes: a multidisciplinary consensus statement. Thyroid 24(9), 1341–1349 (2014). https://doi.org/10.1089/thy.2014.0110

    Article  PubMed  Google Scholar 

  124. H.J. Moon, J.Y. Kwak, M.J. Kim, E.J. Son, E.K. Kim, Can vascularity at power Doppler US help predict thyroid malignancy? Radiology 255(1), 260–269 (2010). https://doi.org/10.1148/radiol.09091284

    Article  PubMed  Google Scholar 

  125. D.W. Kim, S.J. Jung, J.W. Eom, T. Kang, Color Doppler features of solid, round, isoechoic thyroid nodules without malignant sonographic features: a prospective cytopathological study. Thyroid 23(4), 472–476 (2013). https://doi.org/10.1089/thy.2012.0238

    Article  PubMed  Google Scholar 

  126. H.J. Moon, J.M. Sung, E.K. Kim, J.H. Yoon, J.H. Youk, J.Y. Kwak, Diagnostic performance of gray-scale US and elastography in solid thyroid nodules. Radiology 262(3), 1002–1013 (2012). https://doi.org/10.1148/radiol.11110839

    Article  PubMed  Google Scholar 

  127. U. Unluturk, M.F. Erdogan, O. Demir, S. Gullu, N. Baskal, Ultrasound elastography is not superior to grayscale ultrasound in predicting malignancy in thyroid nodules. Thyroid 22(10), 1031–1038 (2012). https://doi.org/10.1089/thy.2011.0502

    Article  PubMed  Google Scholar 

  128. C. Asteria, A. Giovanardi, A. Pizzocaro, L. Cozzaglio, A. Morabito, F. Somalvico, A. Zoppo, US-elastography in the differential diagnosis of benign and malignant thyroid nodules. Thyroid 18(5), 523–531 (2008). https://doi.org/10.1089/thy.2007.0323

    Article  PubMed  Google Scholar 

  129. Q. Peng, C. Niu, Q. Zhang, M. Zhang, S. Chen, Q. Peng, Mummified thyroid nodules: conventional and contrast-enhanced ultrasound features. J. Ultrasound Med. (2018). https://doi.org/10.1002/jum.14712

  130. A. Lacout, C. Chevenet, P.Y. Marcy, Mummified thyroid syndrome. AJR Am. J. Roentgenol. 206(4), 837–845 (2016). https://doi.org/10.2214/AJR.15.15267

    Article  PubMed  Google Scholar 

  131. Y. Peng, W. Zhou, W.W. Zhan, S.Y. Xu, Ultrasonographic assessment of differential diagnosis between degenerating cystic thyroid nodules and papillary thyroid microcarcinomas. World J. Surg. 41(10), 2538–2544 (2017). https://doi.org/10.1007/s00268-017-4060-1

    Article  PubMed  Google Scholar 

  132. Q. Wu, Y. Wang, Y. Li, B. Hu, Z.Y. He, Diagnostic value of contrast-enhanced ultrasound in solid thyroid nodules with and without enhancement. Endocrine 53(2), 480–488 (2016). https://doi.org/10.1007/s12020-015-0850-0

    Article  CAS  PubMed  Google Scholar 

  133. J.Q. Zhou, Y.Y. Song, W.W. Zhan, X. Wei, S. Zhang, R.F. Zhang, Y. Gu, X. Chen, L.Y. Shi, X.M. Luo, L.C. Yang, Q.Y. Li, B.Y. Bai, X.H. Ye, H. Zhai, H. Zhang, X.H. Jia, Y.J. Dong, J.W. Zhang, Z.F. Yang, H.T. Zhang, Y. Zheng, W.W. Xu, L.M. Lai, L.X. Yin, The Superficial Organ and Vascular Ultrasound Group of the Society of Ultrasound in Medicine of Chinese Medical Association, The Chinese Artificial Intelligence Alliance for Thyroid and Breast Ultrasound, Thyroid Imaging Reporting and Data System (TIRADS) for ultrasound features of nodules: multicentric retrospective study in China. Endocrine in press (2020)

  134. C.S. Park, S.H. Kim, S.L. Jung, B.J. Kang, J.Y. Kim, J.J. Choi, M.S. Sung, H.W. Yim, S.H. Jeong, Observer variability in the sonographic evaluation of thyroid nodules. J. Clin. Ultrasound 38(6), 287–293 (2010). https://doi.org/10.1002/jcu.20689

    Article  PubMed  Google Scholar 

  135. C. Cappelli, I. Pirola, E. Gandossi, A.M. Formenti, B. Agosti, M. Castellano, Ultrasound findings of subacute thyroiditis: a single institution retrospective review. Acta Radiol. 55(4), 429–433 (2014). https://doi.org/10.1177/0284185113498721

    Article  CAS  PubMed  Google Scholar 

  136. S.Y. Park, E.K. Kim, M.J. Kim, B.M. Kim, K.K. Oh, S.W. Hong, C.S. Park, Ultrasonographic characteristics of subacute granulomatous thyroiditis. Korean J. Radiol. 7(4), 229–234 (2006). https://doi.org/10.3348/kjr.2006.7.4.229

    Article  PubMed  PubMed Central  Google Scholar 

  137. J.A. Bonavita, Sonographic patterns of benign thyroid nodules. AJR Am. J. Roentgenol. 198(1), W102–103 (2012). https://doi.org/10.2214/AJR.11.7737

    Article  PubMed  Google Scholar 

  138. V. Virmani, I. Hammond, Sonographic patterns of benign thyroid nodules: verification at our institution. AJR Am. J. Roentgenol. 196(4), 891–895 (2011). https://doi.org/10.2214/AJR.10.5363

    Article  PubMed  Google Scholar 

  139. J.A. Bonavita, J. Mayo, J. Babb, G. Bennett, T. Oweity, M. Macari, J. Yee, Pattern recognition of benign nodules at ultrasound of the thyroid: which nodules can be left alone? AJR Am. J. Roentgenol. 193(1), 207–213 (2009). https://doi.org/10.2214/AJR.08.1820

    Article  PubMed  Google Scholar 

  140. I. Zosin, M. Balas, Clinical, ultrasonographical and histopathological aspects in Hashimoto’s thyroiditis associated with malignant and benign thyroid nodules. Endokrynol. Pol. 64(4), 255–262 (2013)

    Article  PubMed  Google Scholar 

  141. J.D. Iannuccilli, J.J. Cronan, J.M. Monchik, Risk for malignancy of thyroid nodules as assessed by sonographic criteria: the need for biopsy. J. Ultrasound Med. 23(11), 1455–1464 (2004). https://doi.org/10.7863/jum.2004.23.11.1455

    Article  PubMed  Google Scholar 

  142. H.K. Jung, S.W. Hong, E.K. Kim, J.H. Yoon, J.Y. Kwak, Diffuse sclerosing variant of papillary thyroid carcinoma: sonography and specimen radiography. J. Ultrasound Med. 32(2), 347–354 (2013). https://doi.org/10.7863/jum.2013.32.2.347

    Article  PubMed  Google Scholar 

  143. Y. Zhang, D. Xia, P. Lin, L. Gao, G. Li, W. Zhang, Sonographic findings of the diffuse sclerosing variant of papillary carcinoma of the thyroid. J. Ultrasound Med. 29(8), 1223–1226 (2010). https://doi.org/10.7863/jum.2010.29.8.1223

    Article  PubMed  Google Scholar 

  144. J.H. Kim, J.H. Baek, H.K. Lim, H.S. Ahn, S.M. Baek, Y.J. Choi, Y.J. Choi, S.R. Chung, E.J. Ha, S.Y. Hahn, S.L. Jung, D.S. Kim, S.J. Kim, Y.K. Kim, C.Y. Lee, J.H. Lee, K.H. Lee, Y.H. Lee, J.S. Park, H. Park, J.H. Shin, C.H. Suh, J.Y. Sung, J.S. Sim, I. Youn, M. Choi, D.G. Na; Guideline Committee for the Korean Society of Thyroid Radiology, Korean Society of Radiology, 2017 Thyroid Radiofrequency Ablation Guideline: Korean Society of Thyroid Radiology. Korean J. Radiol. 19(4), 632–655 (2018). https://doi.org/10.3348/kjr.2018.19.4.632

    Article  PubMed  PubMed Central  Google Scholar 

  145. H. Kim, H.J. Jung, S.Y. Lee, T.K. Kwon, K.H. Kim, M.W. Sung, J. Hun Hah, Prognostic factors of locally invasive well-differentiated thyroid carcinoma involving the trachea. Eur. Arch. Otorhinolaryngol. 273(7), 1919–1926 (2016). https://doi.org/10.1007/s00405-015-3724-4

    Article  PubMed  Google Scholar 

  146. W. Chen, J. Lei, J. You, Y. Lei, Z. Li, R. Gong, H. Tang, J. Zhu, Predictive factors and prognosis for recurrent laryngeal nerve invasion in papillary thyroid carcinoma. Onco Targets Ther. 10, 4485–4491 (2017). https://doi.org/10.2147/OTT.S142799

    Article  PubMed  PubMed Central  Google Scholar 

  147. A. Al Afif, B.A. Williams, M.H. Rigby, M.J. Bullock, S.M. Taylor, J. Trites, R.D. Hart, Multifocal papillary thyroid cancer increases the risk of central lymph node metastasis. Thyroid 25(9), 1008–1012 (2015). https://doi.org/10.1089/thy.2015.0130

    Article  PubMed  Google Scholar 

  148. L. Genpeng, L. Jianyong, Y. Jiaying, J. Ke, L. Zhihui, G. Rixiang, Z. Lihan, Z. Jingqiang, Independent predictors and lymph node metastasis characteristics of multifocal papillary thyroid cancer. Medicine 97(5), e9619 (2018). https://doi.org/10.1097/MD.0000000000009619

    Article  PubMed  PubMed Central  Google Scholar 

  149. J. Jiang, H. Lu, Immediate surgery might be a better option for subcapsular thyroid microcarcinomas. Int. J. Endocrinol. 2019, 6 (2019). https://doi.org/10.1155/2019/3619864

    Article  Google Scholar 

  150. S. Schenke, P. Seifert, M. Zimny, T. Winkens, I. Binse, R. Gorges, Risk stratification of thyroid nodules using the Thyroid Imaging Reporting and Data System (TIRADS): the omission of thyroid scintigraphy increases the rate of falsely suspected lesions. J. Nucl. Med. 60(3), 342–347 (2019). https://doi.org/10.2967/jnumed.118.211912

    Article  CAS  PubMed  Google Scholar 

  151. W. Zhou, S. Jiang, W. Zhan, J. Zhou, S. Xu, L. Zhang, Ultrasound-guided percutaneous laser ablation of unifocal T1N0M0 papillary thyroid microcarcinoma: preliminary results. Eur. Radiol. 27(7), 2934–2940 (2017). https://doi.org/10.1007/s00330-016-4610-1

    Article  PubMed  Google Scholar 

  152. D. Teng, G. Sui, C. Liu, Y. Wang, Y. Xia, H. Wang, Long-term efficacy of ultrasound-guided low power microwave ablation for the treatment of primary papillary thyroid microcarcinoma: a 3-year follow-up study. J. Cancer Res. Clin. Oncol. 144(4), 771–779 (2018). https://doi.org/10.1007/s00432-018-2607-7

    Article  PubMed  Google Scholar 

  153. S.Y. Jeong, J.H. Baek, Y.J. Choi, S.R. Chung, T.Y. Sung, W.G. Kim, T.Y. Kim, J.H. Lee, Radiofrequency ablation of primary thyroid carcinoma: efficacy according to the types of thyroid carcinoma. Int. j. Hyperth. Off. J. Eur. Soc. Hyperth. Oncol. N. Am. Hyperth. Group 1–6 (2018). https://doi.org/10.1080/02656736.2018.1427288

  154. W. Zhou, X. Ni, S. Xu, L. Zhang, Y. Chen, W. Zhan, Ultrasound-guided laser ablation versus microwave ablation for patients with unifocal papillary thyroid microcarcinoma: a retrospective study. Lasers Surg. Med. (2020). https://doi.org/10.1002/lsm.23238

  155. M.H. Ge, D. Xu, A.K. Yang, R.C. Cheng, H. Sun, H.C. Wang, J.Q. Zhang, Z.G. Cheng, Z.Y. wu, Expert consensus on thermal ablation for thyroid benign nodes, microcarcinoma and metastatic cervical lymph nodes (2018 Edition). China Cancer 27(10), 768–773 (2018)

    Google Scholar 

  156. Thyroid Cancer committee of Zhejiang Anti-Cancer Association, Expert consensus on thermal ablation for thyroid benign nodes, microcarcinoma and metastatic cervical lymph nodes (2015 edition). Chin. J. Gen. Surg. 25(7), 944–946 (2016). https://doi.org/10.3978/j.issn.1005-6947.2016.07.002

    Article  Google Scholar 

  157. M. Gao, M. Ge, Q. Ji, R. Cheng, H. Lu, H. Guan, L. Gao, Z. Guo, T. Huang, X. Huang, X. Li, Y. Lin, Q. Liu, X. Ni, Y. Pan, J. Qin, Z. Shan, H. Sun, X. Wang, Z. Xu, Y. Yu, D. Zhao, N. Zhang, S. Zhang, Y. Zheng, J. Zhu, D. Li, X. ZhengChinese Association of Thyroid Oncology (CATO), Chinese Anti-Cancer Association, 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma. Cancer Biol. Med 14(3), 203–211 (2017). https://doi.org/10.20892/j.issn.2095-3941.2017.0051

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We would like to express our sincere gratitude to all doctors from the Chinese Artificial Intelligence Alliance for Thyroid and Breast Ultrasound (CAAU) member hospitals who provided ultrasound data on thyroid nodules for this study.

The Superficial Organ and Vascular Ultrasound Group of the Society of Ultrasound in Medicine of the Chinese Medical Association

BaoMing Luo24, BeiJian Huang25, ChaoYang Wen26, ChengRong Mi27, DaoZhong Huang28, EnSheng Xue29, Gang Wu30, GuoQing Du31, HaiTao Ran32, HuiJuan Xiang33, JiaAn Zhu34, Jian Wang35, JianChu Li36, Jie Tang37, Jing Li38, JingChun Yang39, Lei Zhang39, LiGang Cui40, LingYun Bao41, LiXue Yin42, Man Lu43, Mei Zhu44, Min Chen45, Nima Yuzhen46, PengFei Zhang47, Rong Wu48, RuiJun Guo49, ShaoYun Hao24, ShiBao Fang50, Tao Chen51, WeiWei Zhan52, Ying Zhu53, YingJia Li54, YongPing Lu55, YouBin Deng28, YuanYi Zheng56, Yue Chen57, YuKun Luo37, YuLan Peng58

The Chinese Artificial Intelligence Alliance for Thyroid and Breast Ultrasound

Bai BaoYan59, Cai YuanJin60, Chang Xin61, Che Guihua62, Chen Fu63, Chen HongTian64, Chen HongYan65,66, Chen HuiPin67, Chen Jiehuan68, Chen NianQiao69, Chen Wu35, Chen Xinguang70, Chen XiuPing71, Cui Guanghe72, Dai LiPing73, Deng XueDong74, Dong LiLi75, Du Gang76, Fang Chao77, Fang FengKai78, Fei ZhengDong79, Feng LiLi80, Fu Jian81, Guan Ling82, Guo JianQin83, Han Wen84, He Nianan85, He ShaoZheng86, He XueMei87, Hou AiQin88, Hu Jie89, Hu LiYan90, Huang DingWei91, Huang JianYuan92, Huang Li93, Huang PeiPei94, Huang WeiWei95, Jia LiQiong96, Jiang Xinhui97, Kang huiLi98, Kong XiangChong99, Lei XiaoQing100, Li AnYang101, Li Chen102, Li Cheng103, Li ChuanYin104, Li Dong105, Li HaiYan106, Li HongMei107, Li HuiWen108, Li JianXin109, Li Ning110, Li QiaoYing111, Li QinYing112, Li Tao113, Li WenDong114, Li XingYun115, Li Zhao116, Liang GuoSheng117, Lin Jie118, Liu Aihua119, Liu HongMin120, Liu Jia121, Liu Kun122, Liu YanChao123, Lou KeXin124, Lu YeJun125, Mao Feng126, Miao Juan127, Ni XueJun128, Pan XiaoJie129, Pang Yun130, Peng Mei131, Peng ZhenYi72, Pi YanMin132, Qi TingYue133, Qin QianMiao134, Qing Shunhua135, Qu JianFeng136, Ren Jinhe137, RenaguLi AiSha138, Ru RongRong139, Shen Tao140, Shi HongWei141, Shi Jie142, Shi LiYing143, Shou JinDuo144, Song LinLin145, Su DeMin146, Sun AnYi147, Sun Zhuogui148, Tang Binhui149, Tang Li Na150, Wan Qing151, Wang Fang152,153, Wang Jing154, Wang JinPing155, Wang Li156, Wang Wei157, Wang XinFang158, Wang YaLi159, Wang YanBin160, Wang YanQing161, Wang YanZhen162, Wang YingChun163, Wang YuanSheng46, Wang ZhaoRui164, Wu ChangJun165, Wu HaiYan166, Wu Jing167, Wu JinYu168, Wu Liang169, Wu LinSong170, Wu Qing171, Wu Tao172, Wu Ting74,173, Wu WenJing174, Wu ZhiLing175, Wu ZhongQiu176, Xiao LiFang177, Xie ChuanWen178, Xie Xiaohong179, Xu Quan180, Xue Dan181, Yan JingBin182, Yan JiPing183, Yang JianQing184, Yang Jie185, Yang QingYa186, Yang XiaoQing187, Yang XueWen188, Yang Yan189, Yang YingMei190, Yang Yinguang191, Ye Xinhua192, Ye YuQuan193, You Tao194, Yu Liang195, Yu XiaoQin196, Yuan Hui197, Yuan Zhihong74, Ze Liang198, Zeng Shue199, Zhang Hui200, Zhang Jian201, Zhang JianLei202, Zhang LiJuan203, Zhang LiLi204, Zhang Na205, Zhang PanPan206, Zhang Tong207, Zhang WenJun208, Zhang XiaoDong209, Zhang Yan210,211, Zhang Yuhong212, Zhang Yuhua213, Zhang YunFei214, Zhang ZiZhen32, Zhang ZiZhen215, Zhao Feng216, Zhao Li217, Zhao Yu218, Zhou Hong219, Zhou JianQiao103, Zhou Na220, Zhou Peng221, Zhou Ruhai222, Zhou XianLi31, Zhou YiBo223, Zhu Bin224, Zhu LiSha225, Zhu Zheng226, Zou Bao227

Author information

Authors and Affiliations

  1. Department of Ultrasound, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200025, China

    JianQiao Zhou, Wei Zhou & WeiWei Zhan

  2. Institute of Ultrasound in Medicine, The Affiliated Sichuan Provincial People’s Hospital of Electronic Science and Technology University of China, Chengdu, 610071, China

    LiXue Yin

  3. Department of Diagnostic and Therapeutic Ultrasound, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China

    Xi Wei & Sheng Zhang

  4. Department of Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China

    YanYan Song

  5. Department of Ultrasound, SunYat-sen Memorial Hospital, SunYat-sen University, Guangzhou, 510120, China

    BaoMing Luo

  6. Department of Ultrasound, Peking Union Medical College Hospital, Beijing, 100730, China

    JianChu Li

  7. Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China

    LinXue Qian

  8. Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China

    LiGang Cui & Wen Chen

  9. Department of Ultrasound, Peking University International Hospital, Beijing, 102206, China

    ChaoYang Wen

  10. Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, 610041, China

    YuLan Peng

  11. Department of Ultrasound, The Affiliated Sichuan Provincial People’s Hospital of Electronic Science and Technology University of China, Chengdu, 610071, China

    Qin Chen

  12. Department of Ultrasound, Sichuan Cancer Hospital, Chengdu, 610041, China

    Man Lu

  13. Department of Ultrasound, Fudan University Shanghai Cancer Center, Shanghai, 200032, China

    Min Chen

  14. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

    Min Chen

  15. Department of Ultrasound, Shanghai First People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 201620, China

    Rong Wu

  16. Department of Ultrasound, Fujian Medical University Union Hospital, Fuzhou, 350001, China

    EnSheng Xue

  17. Department of Ultrasound, Nanfang Hospital of Southern Medical University, Guangzhou, 510515, China

    YingJia Li

  18. Department of Ultrasound, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming, 650031, China

    LiChun Yang

  19. Department of Ultrasound, General Hospital of Ningxia Medical University, Yinchuan, 750021, China

    ChengRong Mi

  20. Department of Ultrasound, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China

    RuiFang Zhang

  21. Department of Ultrasound, Henan Provincial People’s Hospital, Zhengzhou, 450003, China

    Gang Wu

  22. Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China

    GuoQing Du

  23. Department of Ultrasound, Tongji Hospital, Tongji Medical Colloge, Huazhong University of Science and Technology, Wuhan, 430030, China

    DaoZhong Huang

  24. SunYat-sen Memorial Hospital, SunYat-sen University, Guangzhou, China

    BaoMing Luo & ShaoYun Hao

  25. Zhongshan Hospital, Fudan University, Shanghai, China

    BeiJian Huang

  26. Peking University International Hospital, Beijing, China

    ChaoYang Wen

  27. General Hospital of Ningxia Medical University, Yinchuan, China

    ChengRong Mi

  28. Tongji Hospital, Tongji Medical Colloge, Huazhong University of Science and Technology, Wuhan, China

    DaoZhong Huang & YouBin Deng

  29. Fujian Medical University Union Hospital, Fuzhou, China

    EnSheng Xue

  30. Henan Provincial People’s Hospital, Zhengzhou, China

    Gang Wu

  31. The Second Affiliated Hospital of Harbin Medical University, Harbin, China

    GuoQing Du & Zhou XianLi

  32. The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

    HaiTao Ran & Zhang ZiZhen

  33. The General Hospital of the Central Theater Command of the PLA, Wuhan, China

    HuiJuan Xiang

  34. Peking University People’s Hospital, Beijing, China

    JiaAn Zhu

  35. The First Hospital of Shanxi Medical University, Taiyuan, China

    Jian Wang & Chen Wu

  36. Peking Union Medical College Hospital, Beijing, China

    JianChu Li

  37. The PLA General Hospital, Beijing, China

    Jie Tang & YuKun Luo

  38. Shengjing Hospital Affiliated to China Medical University, Shenyang, China

    Jing Li

  39. Xuanwu Hospital of Capital Medical University, Beijing, China

    JingChun Yang & Lei Zhang

  40. Peking University Third Hospital, Beijing, China

    LiGang Cui

  41. Hangzhou First People’s Hospital, Hangzhou, China

    LingYun Bao

  42. The Affiliated Sichuan Provincial People’s Hospital of Electronic Science and Technology University of China, Chengdu, China

    LiXue Yin

  43. Sichuan Cancer Hospital, Chengdu, China

    Man Lu

  44. The First Affiliated Hospital of Kunming Medical University, Kunming, China

    Mei Zhu

  45. Department of Oncology, Fudan University Shanghai Cancer Center, Shanghai, China

    Min Chen

  46. Tibet Autonomous Region People’s Hospital, Lhasa, China

    Nima Yuzhen & Wang YuanSheng

  47. Shandong University Qilu Hospital, Jinan, China

    PengFei Zhang

  48. Shanghai First People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

    Rong Wu

  49. Chaoyang Hospital of Capital Medical University, Beijing, China

    RuiJun Guo

  50. Affiliated Hospital of Qingdao University, Qingdao, China

    ShiBao Fang

  51. Beijing Jishuitan Hospital, Beijing, China

    Tao Chen

  52. Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    WeiWei Zhan

  53. Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

    Ying Zhu

  54. Nanfang Hospital of Southern Medical University, Guangzhou, China

    YingJia Li

  55. The Second People’s Hospital of Yunnan Province, Kunming, China

    YongPing Lu

  56. Shanghai Sixth People’s Hospital, Shanghai, China

    YuanYi Zheng

  57. Huadong Hospital Affiliated to Fudan University, Shanghai, China

    Yue Chen

  58. West China Hospital of Sichuan University, Chengdu, China

    YuLan Peng

  59. Yanan University Affiliated Hospital, Yanan, China

    Bai BaoYan

  60. Shishou People’s Hospital, Shishou, China

    Cai YuanJin

  61. The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Nanjing, China

    Chang Xin

  62. Funing People’s Hospital of Jiangsu Province, Funing, China

    Che Guihua

  63. Baotou Central Hospital, Baotou, China

    Chen Fu

  64. Hunan Provincial People’s Hospital, Hunan, China

    Chen HongTian

  65. FuYangShi Hopital of TCM Fuyang Traditional Chinese Medicine Hospital, Fuyang, China

    Chen HongYan

  66. Minhang Hospital Affiliated to Fudan Universitg, Shanghai, China

    Chen HongYan

  67. Zhongshan Hospital Xiamen University, Xiamen, China

    Chen HuiPin

  68. The Binhai Bay Central Hospital of Dongguan, Dongguan, China

    Chen Jiehuan

  69. Dali Second People’s Hospital, Dali, China

    Chen NianQiao

  70. Inner Mongolia Forestry General Hospital, Yakeshi, China

    Chen Xinguang

  71. Binzhou Center Hospital, Binzhou, China

    Chen XiuPing

  72. Binzhou Medical University Hospital, Binzhou, China

    Cui Guanghe & Peng ZhenYi

  73. Jiangxi Integrated Chinese and Western Medicine Hospital, Nanchang, China

    Dai LiPing

  74. Suzhou Municipal Hospital, Suzhou, China

    Deng XueDong, Wu Ting & Yuan Zhihong

  75. The People’s Hospital Of Leshan, Leshan, China

    Dong LiLi

  76. Ansteel Group General Hospital, Anshan, China

    Du Gang

  77. Zhabei Central Hospital of Jing’an District, Shanghai, China

    Fang Chao

  78. West Central Hospital of Hainan, Haikou, China

    Fang FengKai

  79. Shuyang Hospital Affiliated to Xuzhou Medical University, Xuzhou, China

    Fei ZhengDong

  80. Jiangxi Provincial People’s Hospital, Nanchang, China

    Feng LiLi

  81. Hai’an Hospital Affiliated to Nantong University, Haian, China

    Fu Jian

  82. Gansu Provincial Cancer Hospital, Lanzhou, China

    Guan Ling

  83. Qinghai Provincial People’s Hospital, Xining, China

    Guo JianQin

  84. The Third Affiliated Hospital of Henan University of Science and Technology, Luoyang, China

    Han Wen

  85. The First Affiliated Hospital Division of Life Sciences and Medicine University of Science and Technology of China/Anhui Provincial Hospital, Hefei, China

    He Nianan

  86. The Second Affiliated Hospital of Fujian Medical University, Fuzhou, China

    He ShaoZheng

  87. The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

    He XueMei

  88. Jiangsu Rudong County People’s Hospital, Rudong, China

    Hou AiQin

  89. Hainan General Hospital, Haikou, China

    Hu Jie

  90. Cangzhou People’s Hospital, Cangzhou, China

    Hu LiYan

  91. Hunan Provincial Hospital of Traditional Chinese Medicine, Changsha, China

    Huang DingWei

  92. The First Affiliated Hospital of Guangxi Medical Universtiy, Nanning, China

    Huang JianYuan

  93. The First Affiliated Hospital of Hainan Medical College, Haikou, China

    Huang Li

  94. Wenzhou People’s Hospital, Wenzhou, China

    Huang PeiPei

  95. The First People’s Hospital of Jiashan, Jiashan, China

    Huang WeiWei

  96. Baoshan Branch of Shanghai First People’s Hospital, Shanghai, China

    Jia LiQiong

  97. Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China

    Jiang Xinhui

  98. Shanghai Punan hospital of Pudong New Ditrict, Shanghai, China

    Kang huiLi

  99. Qindao Municipal Hospital, Qindao, China

    Kong XiangChong

  100. The People’s Hospital of Shimen County, Shimen, China

    Lei XiaoQing

  101. The Second People’s Hospital of Lu An City/Affiliated Hospital of West Anhui Health Vocationnal College, Luan, China

    Li AnYang

  102. Jilin Cancer Hospital, Jilin, China

    Li Chen

  103. Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

    Li Cheng & Zhou JianQiao

  104. AnYang Tumor Hospital, Anyang, China

    Li ChuanYin

  105. Qingyang City Hospital of Traditional Chinese Medicine, Qingyang, China

    Li Dong

  106. Shanxi Zhongtiaoshan Group General Hospital, Yuncheng, China

    Li HaiYan

  107. The People’s Hospital of Mishan City, Mishan, China

    Li HongMei

  108. Ordos Central Hospital, Ordos, China

    Li HuiWen

  109. Weihai Municipal Hospital West Division, Weihai, China

    Li JianXin

  110. Yunnan Cancer Hospital and The Third Affiliated Hospital of Kunming Medical University, Kunming, China

    Li Ning

  111. Tangdu Hospital, Xian, China

    Li QiaoYing

  112. Puyang Traditional Chinese Medicine Hospital, Puyang, China

    Li QinYing

  113. The Third Hospital of Changsha, Changsha, China

    Li Tao

  114. Cang Xian Hospital, Cangxian, China

    Li WenDong

  115. Shaoxing People’s Hospital, Shaoxing, China

    Li XingYun

  116. The second Affiliated Hospital of Kunming Medical University, Kunming, China

    Li Zhao

  117. Puyang Oilfield General Hospital, Puyang, China

    Liang GuoSheng

  118. Mianyang Central Hospital, Mianyang, China

    Lin Jie

  119. The Sixth People’s Hospital of Wuhan, Wuhan, China

    Liu Aihua

  120. Xingang Central Hospital of Xinyu City, Xinyu, China

    Liu HongMin

  121. Dalian Municipal Central Hospital Affiliated Of Dalian Medical University, Dalian, China

    Liu Jia

  122. The Third People’s Hospital Of Hubei Province, Shijiazhuang, China

    Liu Kun

  123. HanDan Central Hospital, Handan, China

    Liu YanChao

  124. Xuzhou Central Hospital, Xuzhou, China

    Lou KeXin

  125. The First People’s Hospital of Changzhou, Changzhou, China

    Lu YeJun

  126. Ningbo First Hospital, Ningbo, China

    Mao Feng

  127. Zigong Fourth People’s Hospital, Zigong, China

    Miao Juan

  128. Affiliated Hospital of Nantong University, Nantong, China

    Ni XueJun

  129. Central Hospital of China Petroleum and Natural Gas Corporation, Langfang, China

    Pan XiaoJie

  130. The Third People’s Hospital of Yunnan Province, Kunming, China

    Pang Yun

  131. Second Affiliated Hospital of Anhui Medical University, Hefei, China

    Peng Mei

  132. Shuangyashan People’s Hospital, Shuangyashan, China

    Pi YanMin

  133. Affiliated Hospital of Yangzhou Universtiy, Yangzhou, China

    Qi TingYue

  134. North Hospital of Huashan Hospital Affiliated to Shanghai Medical College of Fudan University, Shanghai, China

    Qin QianMiao

  135. Nanjing Pukou District Central Hospital, Nanjing, China

    Qing Shunhua

  136. Xinyang Central Hospital, Xinyang, China

    Qu JianFeng

  137. Linyi City People Hospital, Linyi, China

    Ren Jinhe

  138. Kashi First People’s Hospital, Kashi, China

    RenaguLi AiSha

  139. Zhejiang Xiaoshan Hospital, Hangzhou, China

    Ru RongRong

  140. 463 Hospital of PLA, Shenyang, China

    Shen Tao

  141. Lishui People’s Hospital, Lishui, China

    Shi HongWei

  142. Taizhou Hospital of TCM, Taizhou, China

    Shi Jie

  143. The Affiliated Hospital of Guizhou Medical University, Guiyang, China

    Shi LiYing

  144. Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

    Shou JinDuo

  145. Tianjin Medical University General Hospital, Tianjin, China

    Song LinLin

  146. Henan Luyi Zhenyuan Hospital, Luyi, China

    Su DeMin

  147. Quanzhou First Hospital, Quanzhou, Fujian, China

    Sun AnYi

  148. Beichen TCM Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin, China

    Sun Zhuogui

  149. The Third Hospital of Nanchang, Nanchang, China

    Tang Binhui

  150. Fujian Cancer Hospital, Fuzhou, China

    Tang Li Na

  151. Henan Province Hospital of TCM, Zhengzhou, China

    Wan Qing

  152. Ningxia Fifth People’s Hospital, Shizuishan, China

    Wang Fang

  153. Inner Mongolia People’s Hospital, Hohhot, China

    Wang Fang

  154. Affiliated Hospital, Dali University, Dali, China

    Wang Jing

  155. The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China

    Wang JinPing

  156. Linfen Central Hospital, Linfen, China

    Wang Li

  157. Xiangyang No.1 People’s Hospital, Xiangyang, China

    Wang Wei

  158. Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Nanjing, China

    Wang XinFang

  159. Shenyang Red Cross Hospital, Shenyang, China

    Wang YaLi

  160. TangShan GongRen Hospital, Tangshan, China

    Wang YanBin

  161. People’s Hospital of Zhengzhou, Zhengzhou, China

    Wang YanQing

  162. Central Hospital of Zibo, Zibo, China

    Wang YanZhen

  163. Shanghai Jiading District Central Hospital, Shanghai, China

    Wang YingChun

  164. The Third People’s Hospital of Puyang, Puyang, China

    Wang ZhaoRui

  165. The First Affiliated Hospital of Harbin Medical University, Harbin, China

    Wu ChangJun

  166. Sinopharm Dongfeng General Hospital, Shiyan, China

    Wu HaiYan

  167. Jinan Maternity and Child Health Care Hospital, Jinan, China

    Wu Jing

  168. Harbin The First Hospital, Harbin, China

    Wu JinYu

  169. Heze Municipal Hospital, Heze, China

    Wu Liang

  170. Fu Yang People’s Hospital, Fuyang, China

    Wu LinSong

  171. Ezhou Central Hospital, Ezhou, China

    Wu Qing

  172. Shanghai Fengxian Central Hospital, Shanghai, China

    Wu Tao

  173. Suqian Branch, Jiangsu Province Hospital, Suqian, China

    Wu Ting

  174. Ningbo No.2 Hospital, Ningbo, China

    Wu WenJing

  175. The Third Hospital of Zhangzhou, Zhangzhou, China

    Wu ZhiLing

  176. The 900th Hospital of Joint Service Corps of Chinese PLA, Fuzhou, China

    Wu ZhongQiu

  177. Jilin City Center Hospital, Jilin, China

    Xiao LiFang

  178. Fan County People’s Hospital, Henan province, Fanxian, China

    Xie ChuanWen

  179. Ningbo Yinzhou No.2 Hospital, Ningbo, China

    Xie Xiaohong

  180. The First Affiliated Hospital of USTC, Hefei, China

    Xu Quan

  181. 202 Hospital of PLA, Shenyang, China

    Xue Dan

  182. Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, China

    Yan JingBin

  183. Shanxi Provincial People’s Hospital, Xian, China

    Yan JiPing

  184. The First Hospital of Changsha, Changsha, China

    Yang JianQing

  185. The First People’s Hospital of Dali, Dali, China

    Yang Jie

  186. Wuwei People’s Hospital, Wuwei, China

    Yang QingYa

  187. The First Hospital of Shijiazhuang, Shijiazhuang, China

    Yang XiaoQing

  188. The First People’s Hospital of Yinchuan, Yinchuan, China

    Yang XueWen

  189. The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China

    Yang Yan

  190. BaoShan People’s Hospital, Baoshan, China

    Yang YingMei

  191. Dongguan Third People’s Hospital, Dongguan, China

    Yang Yinguang

  192. The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China

    Ye Xinhua

  193. HeBei General Hospital, Shijiazhuang, China

    Ye YuQuan

  194. The Second Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China

    You Tao

  195. Inner Mongolia Maternal and Child Care Hospital, Hohhot, China

    Yu Liang

  196. Longgang Central Hospital of Shenzhen, Shenzhen, China

    Yu XiaoQin

  197. Xinyi People’s Hospital, Xinyi, China

    Yuan Hui

  198. Dezhou People’s Hospital, Dezhou, China

    Ze Liang

  199. Hubei Cancer Hospital, Wuhan, China

    Zeng Shue

  200. The First Hospital of Jiaxing, Jiaxing, China

    Zhang Hui

  201. Zhoukou Central Hospital, Zhoukou, China

    Zhang Jian

  202. Yan’an People’s Hospital, Yanan, China

    Zhang JianLei

  203. The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China

    Zhang LiJuan

  204. The First Affiliated Hospital of Nanchang University, Nanchang, China

    Zhang LiLi

  205. Baoding Second Central Hospital, Baoding, China

    Zhang Na

  206. Taozhou Hospital Of Zhejiang Province, Taozhou, China

    Zhang PanPan

  207. Chenzhou No. 1 People’s Hospital, Chenzhou, China

    Zhang Tong

  208. Wenjiang District People’s Hospital of Chengdu, Chengdu, China

    Zhang WenJun

  209. The First Affiliated Hospital of Xiamen University, Xiamen, China

    Zhang XiaoDong

  210. Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, China

    Zhang Yan

  211. Hwa Mei hospital, University of Chinese Academy of Sciences (Ningbo No. 2 Hospital), Ningbo, China

    Zhang Yan

  212. Hua Long Hospital, Enshi, China

    Zhang Yuhong

  213. The Third People’s Hospital of Zhengzhou/Cancer Hospital of Henan University/The First Mercy Hospital of Henan Province, Zhengzhou, China

    Zhang Yuhua

  214. The First Hospital of China Medical University, Shenyang, China

    Zhang YunFei

  215. The First People’s Hospital of Qujing City, Qujing, China

    Zhang ZiZhen

  216. Guangming Hospital of Traditional Chinese Medicine, Shanghai, China

    Zhao Feng

  217. Southwest University Hospital, Chongqing, China

    Zhao Li

  218. The Second Affiliated Hospital of Nanchang University, Nanchang, China

    Zhao Yu

  219. Chengdu Third People’s Hospital, Chengdu, China

    Zhou Hong

  220. Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region, Uygur, China

    Zhou Na

  221. Shenzhen Second People’s Hospital, Shenzhen, China

    Zhou Peng

  222. Yinzhou People’s Hospital (Yinzhou Hospital Affiliated to Medical School of Ningbo University), Ningbo, China

    Zhou Ruhai

  223. Jinhua Hospital of Zhejiang University/Jinhua Municipal Central Hospital, Jinhua, China

    Zhou YiBo

  224. The Third People’s Hospital Of Lianshui County, Lianshui, China

    Zhu Bin

  225. People’s Hospital of Yichun City, Yichun, China

    Zhu LiSha

  226. Taicang First People’s Hospital, Taicang, China

    Zhu Zheng

  227. Huainan First People’s Hospital, Huainan, China

    Zou Bao

Authors
  1. JianQiao Zhou
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  2. LiXue Yin
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  3. Xi Wei
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  4. Sheng Zhang
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  5. YanYan Song
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  6. BaoMing Luo
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  7. JianChu Li
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  8. LinXue Qian
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  9. LiGang Cui
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  10. Wen Chen
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  11. ChaoYang Wen
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  12. YuLan Peng
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  13. Qin Chen
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  14. Man Lu
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  15. Min Chen
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  16. Rong Wu
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  17. Wei Zhou
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  18. EnSheng Xue
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  19. YingJia Li
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  20. LiChun Yang
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  21. ChengRong Mi
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  22. RuiFang Zhang
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  23. Gang Wu
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  24. GuoQing Du
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  25. DaoZhong Huang
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  26. WeiWei Zhan
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Consortia

The Superficial Organ and Vascular Ultrasound Group of the Society of Ultrasound in Medicine of the Chinese Medical Association

  • BaoMing Luo
  • , BeiJian Huang
  • , ChaoYang Wen
  • , ChengRong Mi
  • , DaoZhong Huang
  • , EnSheng Xue
  • , Gang Wu
  • , GuoQing Du
  • , HaiTao Ran
  • , HuiJuan Xiang
  • , JiaAn Zhu
  • , Jian Wang
  • , JianChu Li
  • , Jie Tang
  • , Jing Li
  • , JingChun Yang
  • , Lei Zhang
  • , LiGang Cui
  • , LingYun Bao
  • , LiXue Yin
  • , Man Lu
  • , Mei Zhu
  • , Min Chen
  • , Nima Yuzhen
  • , PengFei Zhang
  • , Rong Wu
  • , RuiJun Guo
  • , ShaoYun Hao
  • , ShiBao Fang
  • , Tao Chen
  • , WeiWei Zhan
  • , Ying Zhu
  • , YingJia Li
  • , YongPing Lu
  • , YouBin Deng
  • , YuanYi Zheng
  • , Yue Chen
  • , YuKun Luo
  •  & YuLan Peng

The Chinese Artificial Intelligence Alliance for Thyroid and Breast Ultrasound

  • Bai BaoYan
  • , Cai YuanJin
  • , Chang Xin
  • , Che Guihua
  • , Chen Fu
  • , Chen HongTian
  • , Chen HongYan
  • , Chen HuiPin
  • , Chen Jiehuan
  • , Chen NianQiao
  • , Chen Wu
  • , Chen Xinguang
  • , Chen XiuPing
  • , Cui Guanghe
  • , Dai LiPing
  • , Deng XueDong
  • , Dong LiLi
  • , Du Gang
  • , Fang Chao
  • , Fang FengKai
  • , Fei ZhengDong
  • , Feng LiLi
  • , Fu Jian
  • , Guan Ling
  • , Guo JianQin
  • , Han Wen
  • , He Nianan
  • , He ShaoZheng
  • , He XueMei
  • , Hou AiQin
  • , Hu Jie
  • , Hu LiYan
  • , Huang DingWei
  • , Huang JianYuan
  • , Huang Li
  • , Huang PeiPei
  • , Huang WeiWei
  • , Jia LiQiong
  • , Jiang Xinhui
  • , Kang huiLi
  • , Kong XiangChong
  • , Lei XiaoQing
  • , Li AnYang
  • , Li Chen
  • , Li Cheng
  • , Li ChuanYin
  • , Li Dong
  • , Li HaiYan
  • , Li HongMei
  • , Li HuiWen
  • , Li JianXin
  • , Li Ning
  • , Li QiaoYing
  • , Li QinYing
  • , Li Tao
  • , Li WenDong
  • , Li XingYun
  • , Li Zhao
  • , Liang GuoSheng
  • , Lin Jie
  • , Liu Aihua
  • , Liu HongMin
  • , Liu Jia
  • , Liu Kun
  • , Liu YanChao
  • , Lou KeXin
  • , Lu YeJun
  • , Mao Feng
  • , Miao Juan
  • , Ni XueJun
  • , Pan XiaoJie
  • , Pang Yun
  • , Peng Mei
  • , Peng ZhenYi
  • , Pi YanMin
  • , Qi TingYue
  • , Qin QianMiao
  • , Qing Shunhua
  • , Qu JianFeng
  • , Ren Jinhe
  • , RenaguLi AiSha
  • , Ru RongRong
  • , Shen Tao
  • , Shi HongWei
  • , Shi Jie
  • , Shi LiYing
  • , Shou JinDuo
  • , Song LinLin
  • , Su DeMin
  • , Sun AnYi
  • , Sun Zhuogui
  • , Tang Binhui
  • , Tang Li Na
  • , Wan Qing
  • , Wang Fang
  • , Wang Jing
  • , Wang JinPing
  • , Wang Li
  • , Wang Wei
  • , Wang XinFang
  • , Wang YaLi
  • , Wang YanBin
  • , Wang YanQing
  • , Wang YanZhen
  • , Wang YingChun
  • , Wang YuanSheng
  • , Wang ZhaoRui
  • , Wu ChangJun
  • , Wu HaiYan
  • , Wu Jing
  • , Wu JinYu
  • , Wu Liang
  • , Wu LinSong
  • , Wu Qing
  • , Wu Tao
  • , Wu Ting
  • , Wu WenJing
  • , Wu ZhiLing
  • , Wu ZhongQiu
  • , Xiao LiFang
  • , Xie ChuanWen
  • , Xie Xiaohong
  • , Xu Quan
  • , Xue Dan
  • , Yan JingBin
  • , Yan JiPing
  • , Yang JianQing
  • , Yang Jie
  • , Yang QingYa
  • , Yang XiaoQing
  • , Yang XueWen
  • , Yang Yan
  • , Yang YingMei
  • , Yang Yinguang
  • , Ye Xinhua
  • , Ye YuQuan
  • , You Tao
  • , Yu Liang
  • , Yu XiaoQin
  • , Yuan Hui
  • , Yuan Zhihong
  • , Ze Liang
  • , Zeng Shue
  • , Zhang Hui
  • , Zhang Jian
  • , Zhang JianLei
  • , Zhang LiJuan
  • , Zhang LiLi
  • , Zhang Na
  • , Zhang PanPan
  • , Zhang Tong
  • , Zhang WenJun
  • , Zhang XiaoDong
  • , Zhang Yan
  • , Zhang Yuhong
  • , Zhang Yuhua
  • , Zhang YunFei
  • , Zhang ZiZhen
  • , Zhang ZiZhen
  • , Zhao Feng
  • , Zhao Li
  • , Zhao Yu
  • , Zhou Hong
  • , Zhou JianQiao
  • , Zhou Na
  • , Zhou Peng
  • , Zhou Ruhai
  • , Zhou XianLi
  • , Zhou YiBo
  • , Zhu Bin
  • , Zhu LiSha
  • , Zhu Zheng
  •  & Zou Bao

Corresponding authors

Correspondence to JianQiao Zhou, LiXue Yin or WeiWei Zhan.

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Members of The Superficial Organ and Vascular Ultrasound Group of the Society of Ultrasound in Medicine of the Chinese Medical Association and The Chinese Artificial Intelligence Alliance for Thyroid and Breast Ultrasound are listed below Acknowledgements.

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Zhou, J., Yin, L., Wei, X. et al. 2020 Chinese guidelines for ultrasound malignancy risk stratification of thyroid nodules: the C-TIRADS. Endocrine 70, 256–279 (2020). https://doi.org/10.1007/s12020-020-02441-y

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