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Clinical efficacy of percutaneous cryoablation combined with allogenic NK cell immunotherapy for advanced non-small cell lung cancer

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Abstract

In this study, the safety and clinical efficacy of cryosurgery combined with allogenic NK cell immunotherapy for the treatment of advanced non-small cell lung cancer (NSCLC) were evaluated. From July 2016 to March 2017, we enrolled 60 patients who met the enrollment criteria and divided them into two groups: (1) the simple cryoablation group (n = 30) and (2) the cryoablation combined with allogenic NK cell group (n = 30). The changes in immune function, quality of life, and clinical response were evaluated. We found that allogenic NK cells combined with cryosurgical treatment for advanced NSCLC have a synergistic effect, which not only enhancing the immune function of patients, improving the quality of life, and significantly increasing the response rate (RR) and disease control rate (DCR) compared to cryoablation group. This study is the first clinical trial of allogenic NK cells combined with cryosurgery for the treatment of advanced NSCLC and preliminaily its safety and efficacy.

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Acknowledgements

We would like to thank the native English speaking scientists of Elixigen Company for editing our manuscript. This work was supported by the International Scientific Fund of Fuda Cancer Hospital, Guangzhou, China [Y2016-ZD-004].

Author information

Authors and Affiliations

  1. Department of Biological Treatment Center, Fuda Cancer Hospital, Jinan University School of Medicine, Jinan, China

    Mao Lin, Shu-Zhen Liang, Xiao-Hua Wang, Ying-Qing Liang, Li-Zhi Niu, Ji-Bing Chen, Hai-Bo Li & Ke-Cheng Xu

  2. Fuda Cancer Institute, Guangzhou, China

    Mao Lin, Li-Zhi Niu, Ji-Bing Chen, Hai-Bo Li & Ke-Cheng Xu

  3. Hank Bioengineering Co., Ltd, Shenzhen, China

    Ming-Jie Zhang

  4. Department of Oncology, Fuda Cancer Hospital, Jinan University School of Medicine, Jinan, China

    Li-Zhi Niu & Hai-Bo Li

Authors
  1. Mao Lin
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  2. Shu-Zhen Liang
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  3. Xiao-Hua Wang
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  4. Ying-Qing Liang
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  7. Ji-Bing Chen
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  8. Hai-Bo Li
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  9. Ke-Cheng Xu
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Corresponding authors

Correspondence to Ji-Bing Chen or Hai-Bo Li.

Ethics declarations

This clinical trial was registered at the US National Institutes of Health (ID: NCT02843815; Ph1/Ph2) and was approved by the Ethics Committee of Guangzhou Fuda Cancer Hospital. In accordance with the Declaration of Helsinki, written informed consent was obtained from each participant at the Fuda Cancer Hospital

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The authors declare that they have no conflict of interests.

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Lin, M., Liang, SZ., Wang, XH. et al. Clinical efficacy of percutaneous cryoablation combined with allogenic NK cell immunotherapy for advanced non-small cell lung cancer. Immunol Res 65, 880–887 (2017). https://doi.org/10.1007/s12026-017-8927-x

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  • DOI: https://doi.org/10.1007/s12026-017-8927-x

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