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Resveratrol effects in oral cancer cells: a comprehensive review

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Abstract

Oral cancer is a very common tumor worldwide with high incidence and mortality. The treatment of oral cancer involves surgery, radio- and chemotherapy; however, high failure rates and toxicity are noticed. Thus, the search of new drugs aiming a more effective treatment is welcomed. Natural products present chemopreventive and anti-cancer effects. Resveratrol is a naturally occurring antioxidant that contains several health benefits, including anti-inflammatory and antiproliferative activities. This review discusses the different action mechanisms of resveratrol related in the in vitro and in vivo studies using models of oral cancer.

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Funding

DAR and GNS are recipients from CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, grant number #001). DVS and ACMM are repicients from CAPES (Coordenação de Desenvolvimento de Pessoal de Nivel Superior).

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Authors and Affiliations

  1. Laboratory of Clinical Research, Federal University of Ouro Preto, Ouro Preto, MG, Brazil

    Tamires Cunha Almeida & Glenda Nicioli da Silva

  2. Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, Rua Silva Jardim, UNIFESP, 136, Room 332, Vila Mathias, Santos, SP, 11050-020, Brazil

    Daniel Vitor de Souza, Odair Aguiar Jr, Debora Estadella & Daniel Araki Ribeiro

  3. Department of Pathology, Paulista Medical School, Federal University of São Paulo, UNIFESP, Sao Paulo, SP, Brazil

    Andrea Cristina de Moraes Malinverni

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  1. Tamires Cunha Almeida
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  2. Glenda Nicioli da Silva
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Contributions

Conceptualization: TCA, GNS, DAR. Data search: TCA, GNS, DVS, ACMM, and DAR. Formal analysis: all authors. Writing, review, and editing: all authors.

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Correspondence to Daniel Araki Ribeiro.

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Almeida, T.C., da Silva, G.N., de Souza, D.V. et al. Resveratrol effects in oral cancer cells: a comprehensive review. Med Oncol 38, 97 (2021). https://doi.org/10.1007/s12032-021-01548-0

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