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Roles and Mechanisms of Axon-Guidance Molecules in Alzheimer’s Disease

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Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease that is characterized by progressive memory decline and cognitive dysfunctions. Although the causes of AD have not yet been established, many mechanisms have been proposed. Axon-guidance molecules play the roles in the occurrence and development of AD by participating in different mechanisms. Therefore, what roles do axon-guidance molecules play in AD? This study aimed at elucidating how axon-guidance molecules Netrins, Slits, Semaphorins, and Ephrins regulate the levels of Aβ, hyperphosphorylation of tau protein, Reelin, and other ways through different signaling pathways, in order to show the roles of axon-guidance molecules in the occurrence and development of AD. And it is hoped that this study can provide a theoretical basis and new perspectives in the search for new therapeutic targets for AD.

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Acknowledgements

We would like to acknowledge Haiying Wang, Bingchen Liu, and Xuda Liu for their valuable advices.

Funding

This work was supported by the Natural Science Foundation of Liaoning Province [2020-MS-152]; the Basic Research Fund of Young Program of Higher Education of Liaoning Province [LQNK201735]; the National Natural Science Foundation of China [No. 81302406]; and the Funds for Distinguished Young Scientists in School of Public Health, China Medical University.

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  1. Department of Environmental Health, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China

    Lei Zhang, Zhipeng Qi, Jiashuo Li, Minghui Li, Xianchao Du, Shuang Wang, Bin Xu, Wei Liu, Shuhua Xi, Zhaofa Xu & Yu Deng

  2. Department of Geriatric Neurology, Qilu Hospital of Shandong University, Jinan, China

    Guoyu Zhou

Authors
  1. Lei Zhang
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  2. Zhipeng Qi
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  3. Jiashuo Li
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  4. Minghui Li
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  5. Xianchao Du
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  6. Shuang Wang
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  7. Guoyu Zhou
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  8. Bin Xu
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  9. Wei Liu
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  10. Shuhua Xi
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  11. Zhaofa Xu
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  12. Yu Deng
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Contributions

Each author substantially contributed to the review. Lei Zhang, conception and design and drafting the manuscript; Zhipeng Qi, Jiashuo Li, Minghui Li, Xianchao Du, Shuang Wang, Bin Xu, Wei Liu, Zhaofa Xu, Guoyu Zhou, and Shuhua Xi, revising the manuscript; Yu Deng, conception and design, revising it critically for important intellectual content, and final approval of the version to be published. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yu Deng.

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Zhang, L., Qi, Z., Li, J. et al. Roles and Mechanisms of Axon-Guidance Molecules in Alzheimer’s Disease. Mol Neurobiol 58, 3290–3307 (2021). https://doi.org/10.1007/s12035-021-02311-2

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  • DOI: https://doi.org/10.1007/s12035-021-02311-2

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