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A practical one-pot synthesis of azides directly from alcohols

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Abstract

Alkyl/benzyl azides can be readily synthesized in excellent yields from their corresponding alcohols by stirring a solution of sodium azide in DMSO with a thoroughly ground equimolecular mixture of triphenylphosphine, iodine and imidazole.

Various alkyl and aryl alcohols were converted to their corresponding azides in one-step by stirring a solution of sodium azide with a thoroughly ground equimolecular mixture of triphenylphosphine, iodine and imidazole. The method is highly chemoselective and gives good to excellent yields for primary, secondary and less reactive benzyl alcohols.

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Authors and Affiliations

  1. Department of Chemistry, North Eastern Hill University, Shillong, 793 022, India

    SAMUEL LALTHAZUALA ROKHUM & GHANASHYAM BEZ

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  1. SAMUEL LALTHAZUALA ROKHUM
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  2. GHANASHYAM BEZ
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Correspondence to GHANASHYAM BEZ.

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ROKHUM, S.L., BEZ, G. A practical one-pot synthesis of azides directly from alcohols. J Chem Sci 124, 687–691 (2012). https://doi.org/10.1007/s12039-012-0241-5

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  • DOI: https://doi.org/10.1007/s12039-012-0241-5

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