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A facile approach for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones using a microwave promoted Biginelli protocol in ionic liquid

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Abstract

Carboxy functionalized ionic liquid [cmmim][BF4] has been demonstrated to be an efficient and green catalyst for the one pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones heterocycles under microwave irradiation. The ionic liquid-microwave strategy represents an easy access to Biginelli compounds with high yields and purity. The protocol was found to be compatible with different structurally diverse aldehydes. The ionic liquid was recycled and reused in at least six subsequent reactions with consistent activity.

Carboxy functionalized ionic liquid [cmmim][BF4] is shown to be an efficient and green catalyst for the one pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones heterocycles under microwave irradiation. This methodology represents an easy access to Biginelli compounds with high yields and purity. The ionic liquid was recycled and reused with consistent results.

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Authors and Affiliations

  1. Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120, India

    ABHISHEK N DADHANIA, VAIBHAV K PATEL & DIPAK K RAVAL

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  1. ABHISHEK N DADHANIA
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  2. VAIBHAV K PATEL
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  3. DIPAK K RAVAL
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Correspondence to ABHISHEK N DADHANIA.

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DADHANIA, A.N., PATEL, V.K. & RAVAL, D.K. A facile approach for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones using a microwave promoted Biginelli protocol in ionic liquid. J Chem Sci 124, 921–926 (2012). https://doi.org/10.1007/s12039-012-0278-5

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  • DOI: https://doi.org/10.1007/s12039-012-0278-5

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