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Transcription factor 7-like 2 (TCF7L2) variations associated with earlier age-onset of type 2 diabetes in Thai patients

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References

  • Barrett J. C., Fry B., Maller J. and Daly M. J. 2005 Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263–265.

    Article  PubMed  CAS  Google Scholar 

  • Buzzetti R., Petrone A., Ribaudo M. C., Alemanno I., Zavarella S., Mein C. A. et al. 2004 The common PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity. Eur. J. Hum. Genet. 12, 1050–1054.

    Article  PubMed  CAS  Google Scholar 

  • Cauchi S., Meyre D., Dina C., Choquet H., Samson C., Gallina S. et al. 2006 Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 55, 2903–2908.

    Article  PubMed  CAS  Google Scholar 

  • Chandak G. R., Janipalli C. S., Bhaskar S., Kulkarni S. R., Mohankrishna P., Hattersley A. T. et al. 2007 Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia 50, 63–67.

    Article  PubMed  CAS  Google Scholar 

  • Chang Y. C., Chang T. J., Jiang Y. D., Kuo S. S., Lee K. C., Chiu K. C. et al. 2007 Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population. Diabetes 56, 2631–2637.

    Article  PubMed  CAS  Google Scholar 

  • Freeman H. and Cox R. D. 2006 Type-2 diabetes: a cocktail of genetic discovery. Hum. Mol. Genet. 15, 202–209.

    Article  Google Scholar 

  • Gloyn A. L., Weedon M. N., Owen K. R., Turner M. J., Knight B. A., Hitman G. et al. 2003 Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52, 568–572.

    Article  PubMed  CAS  Google Scholar 

  • Grant S. F., Thorleifsson G., Reynisdottir I., Benediktsson R., Manolescu A., Sainz J. et al. 2006 Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat. Genet. 38, 320–323.

    Article  PubMed  CAS  Google Scholar 

  • Hayashi T., Iwamoto Y., Kaku K., Hirose H. and Maeda S. 2007 Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population. Diabetologia 50, 980–984.

    Article  PubMed  CAS  Google Scholar 

  • Humphries S. E., Gable D., Cooper J. A., Ireland H., Stephens J. W., Hurel S. J. et al. 2006 Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women. J. Mol. Med. 84, 1–10.

    Article  Google Scholar 

  • Lehman D. M., Hunt K. J., Leach R. J., Hamlington J., Arya R., Abboud H. E. et al. 2007 Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans. Diabetes 56, 389–393.

    Article  PubMed  CAS  Google Scholar 

  • Ridderstrale M. and Groop L. 2009 Genetic dissection of type 2 diabetes. Mol. Cell Endocrinol. 297, 10–17.

    Article  PubMed  Google Scholar 

  • Sandhu M. S., Weedon M. N., Fawcett K. A., Wasson J., Debenham S. L., Daly A. et al. 2007 Common variants in WFS1 confer risk of type 2 diabetes. Nat. Genet. 39, 951–953.

    Article  PubMed  CAS  Google Scholar 

  • Scott L. J., Mohlke K. L., Bonnycastle L. L., Willer C. J., Li Y., Duren W. L. et al. 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316, 1341–1345.

    Article  PubMed  CAS  Google Scholar 

  • Silbernagel G., Renner W., Grammer T. B., Hugl S. R., Bertram J., Kleber M. E. et al. 2011 Association of TCF7L2 SNPs with age of onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon like peptide 1. Diabetes Metab. Res. Rev. 27, 499–505.

    Article  PubMed  CAS  Google Scholar 

  • Weedon M. N. 2007 The importance of TCF7L2. Diabet. Med. 24, 1062–1066.

    Article  PubMed  CAS  Google Scholar 

  • Weedon M. N., Schwarz P. E., Horikawa Y., Iwasaki N., Illig T., Holle R. et al. 2003 Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility. Am. J. Hum. Genet. 73, 1208–1212.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

This work was financially supported by Mahidol University Grant and the project for Higher Education Research Promotion and National Research University Development, Office of the Higher Education Commission. WT was supported by a New Researcher Grant (TRG5280002) from the Thailand Research Fund (TRF). NP was supported by Mahidol university research grant. PY is a TRF-Senior Research Scholar. NC was supported by Faculty of Medicine Siriraj Hospital, Mahidol University. We thank all patients and control individuals for their participation in this study.

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Correspondence to PA-THAI YENCHITSOMANUS.

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[Tangjittipokin W., Chongjarean N., Plengvidhya N., Homsanit M. and Yenchitsomanus P. T. 2012 Transcription factor 7-like 2 (TCF7L2) variations associated with earlier age-onset of type 2 diabetes in Thai patients. J. Genet. 91, xx–xx]

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TANGJITTIPOKIN, W., CHONGJAREAN, N., PLENGVIDHYA, N. et al. Transcription factor 7-like 2 (TCF7L2) variations associated with earlier age-onset of type 2 diabetes in Thai patients. J Genet 91, 251–255 (2012). https://doi.org/10.1007/s12041-012-0176-0

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  • DOI: https://doi.org/10.1007/s12041-012-0176-0

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