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Polymorphisms in human DNA repair genes and head and neck squamous cell carcinoma

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Abstract

Genetic polymorphisms in some DNA repair proteins are associated with a number of malignant transformations like head and neck squamous cell carcinoma (HNSCC). Xeroderma pigmentosum group D (XPD) and X-ray repair cross-complementing proteins 1 (XRCC1) and 3 (XRCC3) genes are involved in DNA repair and were found to be associated with HNSCC in numerous studies. To establish our overall understanding of possible relationships between DNA repair gene polymorphisms and development of HNSCC, we surveyed the literature on epidemiological studies that assessed potential associations with HNSCC risk in terms of gene–environment interactions, genotype-induced functional defects in enzyme activity and/or protein expression, and the influence of ethnic origin on these associations. We conclude that large, well-designed studies of common polymorphisms in DNA repair genes are needed. Such studies may benefit from analysis of multiple genes or polymorphisms and from the consideration of relevant exposures that may influence the likelihood of HNSCC when DNA repair capacity is reduced.

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Acknowledgements

I wish to gratefully acknowledge Adouni T. (Chairman of Federal Consulting & Language Services LLC - Home www.fedcls.com, Tampa, Florida, USA) for his assistance in the English revision of the manuscript.

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  1. Marine Ecotoxicology, UR 09-03, Sfax University, IPEIS, BP 805-3018, Sfax, Tunisia

    RIM KHLIFI & Amel Hamza-Chaffai

  2. Bioinformatics Unit, Centre de Biotechnologie de Sfax, P. O. Box 1177, 3018, Sfax, Tunisia

    RIM KHLIFI & Ahmed Rebai

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  1. RIM KHLIFI
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[Khlifi R., Rebai A. and Hamza-Chaffai A. 2012 Polymorphisms in human DNA repair genes and head and neck squamous cell carcinoma. J. Genet. 91, xx–xx]

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KHLIFI, R., Rebai, A. & Hamza-Chaffai, A. Polymorphisms in human DNA repair genes and head and neck squamous cell carcinoma. J Genet 91, 375–384 (2012). https://doi.org/10.1007/s12041-012-0193-z

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