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A knowledgebase resource for interleukin-17 family mediated signaling

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Journal of Cell Communication and Signaling Aims and scope

Abstract

Interleukin-17 (IL-17) belongs to a relatively new family of cytokines that has garnered attention as the signature cytokine of Th17 cells. This cytokine family consists of 6 ligands, which bind to 5 receptor subtypes and induce downstream signaling. Although the receptors are ubiquitously expressed, cellular responses to ligands vary across tissues. The cytokine family is associated with various autoimmune disorders including rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma and psoriasis in addition to being implicated in the pathogenesis of cancer. In addition, this family plays a role in host defense against bacterial and fungal infections. The signaling mechanisms of the IL-17 family of proinflammatory cytokines are not well explored. In this study, we present a resource of literature-annotated reactions induced by IL-17. The reactions are catalogued under 5 categories, namely; molecular association, catalysis, transport, activation/inhibition and gene regulation. A total of 93 molecules and 122 reactions have been annotated. The IL-17 pathway is freely available through NetPath, a resource of signal transduction pathways previously developed by our group.

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Abbreviations

IL-17:

Interleukin- 17

IL-25:

Interleukin- 25

IL-17R:

Interleukin- 17 receptor

PPIs:

Protein-protein interactions

PTMs:

Post-translational modifications

BioPAX:

Biological Pathway Exchange

SBML:

Systems Biology Markup Language

PSI-MI:

Proteomics Standards Initiative for Molecular Interaction

References

  • Angkasekwinai P, Park H, Wang YH, Chang SH, Corry DB, Liu YJ, Zhu Z, Dong C (2007) Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med 204:1509–1517

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Balakrishnan L, Soman S, Patil YB, Advani J, Thomas JK, Desai DV, Kulkarni-Kale U, Harsha HC, Prasad TS, Raju R, Pandey A, Dimitriadis E, Chatterjee A (2013) IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase. Cell Commun Adhes 20:81–86

    Article  CAS  PubMed  Google Scholar 

  • Chang SH, Reynolds JM, Pappu BP, Chen G, Martinez GJ, Dong C (2011) Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E. Immunity 35:611–621

    Article  CAS  PubMed  Google Scholar 

  • Cua DJ, Tato CM (2010) Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol 10:479–489

    Article  CAS  PubMed  Google Scholar 

  • Demir E, Cary MP, Paley S, Fukuda K, Lemer C, Vastrik I, Wu G, D’Eustachio P, Schaefer C, Luciano J, Schacherer F, Martinez-Flores I, Hu Z, Jimenez-Jacinto V, Joshi-Tope G, Kandasamy K, Lopez-Fuentes AC, Mi H, Pichler E, Rodchenkov I, Splendiani A, Tkachev S, Zucker J, Gopinath G, Rajasimha H, Ramakrishnan R, Shah I, Syed M, Anwar N, Babur O, Blinov M, Brauner E, Corwin D, Donaldson S, Gibbons F, Goldberg R, Hornbeck P, Luna A, Murray-Rust P, Neumann E, Reubenacker O, Samwald M, van Iersel M, Wimalaratne S, Allen K, Braun B, Whirl-Carrillo M, Cheung KH, Dahlquist K, Finney A, Gillespie M, Glass E, Gong L, Haw R, Honig M, Hubaut O, Kane D, Krupa S, Kutmon M, Leonard J, Marks D, Merberg D, Petri V, Pico A, Ravenscroft D, Ren L, Shah N, Sunshine M, Tang R, Whaley R, Letovksy S, Buetow KH, Rzhetsky A, Schachter V, Sobral BS, Dogrusoz U, McWeeney S, Aladjem M, Birney E, Collado-Vides J, Goto S, Hucka M, Le Novere N, Maltsev N, Pandey A, Thomas P, Wingender E, Karp PD, Sander C, Bader GD (2010) The BioPAX community standard for pathway data sharing. Nat Biotechnol 28:935–942

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Dilek A, Belviranli ME, Dogrusoz U (2010) VISIBIOweb: visualization and layout services for BioPAX pathway models. Nucleic Acids Res 38:W150–W154

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Ely LK, Fischer S, Garcia KC (2009) Structural basis of receptor sharing by interleukin 17 cytokines. Nat Immunol 10:1245–1251

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423:356–361

    Article  CAS  PubMed  Google Scholar 

  • Gaffen SL (2009) The role of interleukin-17 in the pathogenesis of rheumatoid arthritis. Curr Rheumatol Rep 11:365–370

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Haudenschild D, Moseley T, Rose L, Reddi AH (2002) Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. J Biol Chem 277:4309–4316

    Article  CAS  PubMed  Google Scholar 

  • Huang F, Kao CY, Wachi S, Thai P, Ryu J, Wu R (2007) Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells. J Immunol 179:6504–6513

    Article  CAS  PubMed  Google Scholar 

  • Huang CK, Yang CY, Jeng YM, Chen CL, Wu HH, Chang YC, Ma C, Kuo WH, Chang KJ, Shew JY, Lee WH (2013) Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-kappaB-mediated antiapoptotic pathway. Oncogene 33:2968–2977

    Article  PubMed  Google Scholar 

  • Hucka M, Finney A, Sauro HM, Bolouri H, Doyle JC, Kitano H, Arkin AP, Bornstein BJ, Bray D, Cornish-Bowden A, Cuellar AA, Dronov S, Gilles ED, Ginkel M, Gor V, Goryanin II, Hedley WJ, Hodgman TC, Hofmeyr JH, Hunter PJ, Juty NS, Kasberger JL, Kremling A, Kummer U, Le Novere N, Loew LM, Lucio D, Mendes P, Minch E, Mjolsness ED, Nakayama Y, Nelson MR, Nielsen PF, Sakurada T, Schaff JC, Shapiro BE, Shimizu TS, Spence HD, Stelling J, Takahashi K, Tomita M, Wagner J, Wang J (2003) The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19:524–531

    Article  CAS  PubMed  Google Scholar 

  • Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, Maruoka M, Mao W, Foster J, Kelley RF, Pan G, Gurney AL, de Vos AM, Starovasnik MA (2001) IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J 20:5332–5341

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Kandasamy K, Keerthikumar S, Raju R, Keshava Prasad TS, Ramachandra YL, Mohan S, Pandey A (2009) PathBuilder–open source software for annotating and developing pathway resources. Bioinformatics 25:2860–2862

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A (2010) NetPath: a public resource of curated signal transduction pathways. Genome Biol 11:R3

    Article  PubMed Central  PubMed  Google Scholar 

  • Korn T, Bettelli E, Oukka M, Kuchroo VK (2009) IL-17 and Th17 cells. Annu Rev Immunol 27:485–517

    Article  CAS  PubMed  Google Scholar 

  • Kuestner RE, Taft DW, Haran A, Brandt CS, Brender T, Lum K, Harder B, Okada S, Ostrander CD, Kreindler JL, Aujla SJ, Reardon B, Moore M, Shea P, Schreckhise R, Bukowski TR, Presnell S, Guerra-Lewis P, Parrish-Novak J, Ellsworth JL, Jaspers S, Lewis KE, Appleby M, Kolls JK, Rixon M, West JW, Gao Z, Levin SD (2007) Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J Immunol 179:5462–5473

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Lee J, Ho WH, Maruoka M, Corpuz RT, Baldwin DT, Foster JS, Goddard AD, Yansura DG, Vandlen RL, Wood WI, Gurney AL (2001) IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. J Biol Chem 276:1660–1664

    Article  CAS  PubMed  Google Scholar 

  • Li H, Chen J, Huang A, Stinson J, Heldens S, Foster J, Dowd P, Gurney AL, Wood WI (2000) Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. Proc Natl Acad Sci U S A 97:773–778

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Liu H, Mi S, Li Z, Hua F, Hu ZW (2013) Interleukin 17A inhibits autophagy through activation of PIK3CA to interrupt the GSK3B-mediated degradation of BCL2 in lung epithelial cells. Autophagy 9:730–742

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Lubberts E, Joosten LA, van de Loo FA, Schwarzenberger P, Kolls J, van den Berg WB (2002) Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction. Inflamm Res 51:102–104

    Article  CAS  PubMed  Google Scholar 

  • Lubberts E, Koenders MI, Oppers-Walgreen B, van den Bersselaar L, Coenen-de Roo CJ, Joosten LA, van den Berg WB (2004) Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum 50:650–659

    Article  CAS  PubMed  Google Scholar 

  • Maezawa Y, Nakajima H, Suzuki K, Tamachi T, Ikeda K, Inoue J, Saito Y, Iwamoto I (2006) Involvement of TNF receptor-associated factor 6 in IL-25 receptor signaling. J Immunol 176:1013–1018

    Article  CAS  PubMed  Google Scholar 

  • Maitra A, Shen F, Hanel W, Mossman K, Tocker J, Swart D, Gaffen SL (2007) Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression. Proc Natl Acad Sci U S A 104:7506–7511

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Mellett M, Atzei P, Horgan A, Hams E, Floss T, Wurst W, Fallon PG, Moynagh PN (2012) Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia. Nat Commun 3:1119

    Article  PubMed  Google Scholar 

  • Miossec P (2009) IL-17 and Th17 cells in human inflammatory diseases. Microbes Infect 11:625–630

    Article  CAS  PubMed  Google Scholar 

  • Moseley TA, Haudenschild DR, Rose L, Reddi AH (2003) Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev 14:155–174

  • Onishi RM, Gaffen SL (2010) Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology 129:311–321

  • Orchard S, Kerrien S (2009) Molecular interactions and data standardisation. Methods Mol Biol 604:309–318

    Article  Google Scholar 

  • Qian Y, Kang Z, Liu C, Li X (2010) IL-17 signaling in host defense and inflammatory diseases. Cell Mol Immunol 7:328–333

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Raju R, Balakrishnan L, Nanjappa V, Bhattacharjee M, Getnet D, Muthusamy B, Kurian Thomas J, Sharma J, Rahiman BA, Harsha HC, Shankar S, Prasad TS, Mohan SS, Bader GD, Wani MR, Pandey A (2011) A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway. Database (Oxford) 2011:bar021

  • Rong Z, Wang A, Li Z, Ren Y, Cheng L, Li Y, Wang Y, Ren F, Zhang X, Hu J, Chang Z (2009) IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling. Cell Res 19:208–215

    Article  CAS  PubMed  Google Scholar 

  • Rouvier E, Luciani MF, Mattei MG, Denizot F, Golstein P (1993) CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol 150:5445–5456

    CAS  PubMed  Google Scholar 

  • Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13:2498–2504

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Song X, Zhu S, Shi P, Liu Y, Shi Y, Levin SD, Qian Y (2011) IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol 12:1151–1158

    Article  CAS  PubMed  Google Scholar 

  • Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y (2014) Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. Immunity 40:140–152

    Article  CAS  PubMed  Google Scholar 

  • Sonobe Y, Takeuchi H, Kataoka K, Li H, Jin S, Mimuro M, Hashizume Y, Sano Y, Kanda T, Mizuno T, Suzumura A (2009) Interleukin-25 expressed by brain capillary endothelial cells maintains blood–brain barrier function in a protein kinase Cepsilon-dependent manner. J Biol Chem 284:31834–31842

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Starnes T, Broxmeyer HE, Robertson MJ, Hromas R (2002) Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. J Immunol 169:642–646

    Article  CAS  PubMed  Google Scholar 

  • Toy D, Kugler D, Wolfson M, Vanden Bos T, Gurgel J, Derry J, Tocker J, Peschon J (2006) Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J Immunol 177:36–39

    Article  CAS  PubMed  Google Scholar 

  • van Iersel MP, Kelder T, Pico AR, Hanspers K, Coort S, Conklin BR, Evelo C (2008) Presenting and exploring biological pathways with PathVisio. BMC Bioinforma 9:399

    Article  Google Scholar 

  • Wang W, Fan YQ, Lv Z, Yao XJ, Huang KW, Meng Q, Fang CL, Lee TH, Corrigan CJ, An YQ, Ying S (2012) Interleukin-25 promotes basic fibroblast growth factor expression by human endothelial cells through interaction with IL-17RB, but not IL-17RA. Clin Exp Allergy 42:1604–1614

    Article  CAS  PubMed  Google Scholar 

  • Weaver CT, Hatton RD, Mangan PR, Harrington LE (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25:821–852

    Article  CAS  PubMed  Google Scholar 

  • Wright JF, Bennett F, Li B, Brooks J, Luxenberg DP, Whitters MJ, Tomkinson KN, Fitz LJ, Wolfman NM, Collins M, Dunussi-Joannopoulos K, Chatterjee-Kishore M, Carreno BM (2008) The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex. J Immunol 181:2799–2805

    Article  CAS  PubMed  Google Scholar 

  • Xiang T, Long H, He L, Han X, Lin K, Liang Z, Zhuo W, Xie R, Zhu B (2015) Interleukin-17 produced by tumor microenvironment promotes self-renewal of CD133(+) cancer stem-like cells in ovarian cancer. Oncogene 34:165–176

    Article  CAS  PubMed  Google Scholar 

  • Xiong S, Zhao Q, Rong Z, Huang G, Huang Y, Chen P, Zhang S, Liu L, Chang Z (2003) hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling. J Biol Chem 278:50273–50282

    Article  CAS  PubMed  Google Scholar 

  • Yagi Y, Andoh A, Inatomi O, Tsujikawa T, Fujiyama Y (2007) Inflammatory responses induced by interleukin-17 family members in human colonic subepithelial myofibroblasts. J Gastroenterol 42:746–753

    Article  CAS  PubMed  Google Scholar 

  • Yang RB, Ng CK, Wasserman SM, Komuves LG, Gerritsen ME, Topper JN (2003) A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling. J Biol Chem 278:33232–33238

    Article  CAS  PubMed  Google Scholar 

  • Yang XO, Chang SH, Park H, Nurieva R, Shah B, Acero L, Wang YH, Schluns KS, Broaddus RR, Zhu Z, Dong C (2008) Regulation of inflammatory responses by IL-17F. J Exp Med 205:1063–1075

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Yao Z, Fanslow WC, Seldin MF, Rousseau AM, Painter SL, Comeau MR, Cohen JI, Spriggs MK (1995a) Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 3:811–821

    Article  CAS  PubMed  Google Scholar 

  • Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ (1995b) Human IL-17: a novel cytokine derived from T cells. J Immunol 155:5483–5486

    CAS  PubMed  Google Scholar 

  • Yao Z, Spriggs MK, Derry JM, Strockbine L, Park LS, VandenBos T, Zappone JD, Painter SL, Armitage RJ (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9:794–800

    Article  CAS  PubMed  Google Scholar 

  • Zhong J, Sharma J, Raju R, Palapetta SM, Prasad TS, Huang TC, Yoda A, Tyner JW, van Bodegom D, Weinstock DM, Ziegler SF, Pandey A (2014) TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling. Database (Oxford) 2014:bau007

  • Zisman-Rozen S, Fink D, Ben-Izhak O, Fuchs Y, Brodski A, Kraus MH, Bejar J, Ron D (2007) Downregulation of Sef, an inhibitor of receptor tyrosine kinase signaling, is common to a variety of human carcinomas. Oncogene 26:6093–6098

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We thank the Department of Biotechnology, Government of India for research support to the Institute of Bioinformatics, Bangalore. We thank the Infosys Foundation for research support to the Institute of Bioinformatics. JS is a recipient of Senior Research Fellowship from the Council of Scientific and Industrial Research, Government of India. KKD and AS are recipients of Junior Research Fellowship from the University Grants Commission, Government of India. AAK is a recipient of Senior Research Fellowship from Indian Council of Medical Research, Government of India. HG is a Wellcome Trust/DBT India Alliance Early Career Fellow.

Conflict of interests

The authors declare no conflicts of interest.

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Author notes

  1. Rajesh Raju

    Present address: Computational Biology Group, Cancer Research Program-9, Rajiv Gandhi Centre for Biotechnology, Poojappura, Kerala, 695014, India

Authors and Affiliations

  1. Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India

    Jyoti Sharma, Lavanya Balakrishnan, Keshava K. Datta, Nandini A. Sahasrabuddhe, Aafaque Ahmad Khan, Apeksha Sahu, Rajesh Raju, Aditi Chatterjee, Harsha Gowda & T. S. Keshava Prasad

  2. Manipal University, Madhav Nagar, Manipal, 576104, India

    Jyoti Sharma, Anish Singhal, Aditi Chatterjee & T. S. Keshava Prasad

  3. School of Biotechnology, KIIT University, Bhubaneswar, 751024, India

    Keshava K. Datta, Aafaque Ahmad Khan & Harsha Gowda

  4. Bioinformatics Centre, School of Life Sciences, Pondicherry University, Puducherry, 605014, India

    Apeksha Sahu

  5. Kasturba Medical College, Mangalore, 575001, India

    Anish Singhal

  6. McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Oncology and Pathology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD, 21205, USA

    Derese Getnet & Akhilesh Pandey

  7. Command Hospital (Air Force), Bangalore, 560007, India

    Subramanian Shankar

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  1. Jyoti Sharma
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  2. Lavanya Balakrishnan
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Correspondence to Subramanian Shankar or Akhilesh Pandey.

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Sharma, J., Balakrishnan, L., Datta, K.K. et al. A knowledgebase resource for interleukin-17 family mediated signaling. J. Cell Commun. Signal. 9, 291–296 (2015). https://doi.org/10.1007/s12079-015-0297-3

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